Instruments for Micro-Magnetic Stimulation of the Brain in Animals

动物大脑微磁刺激仪器

• 批准号: 8777770
• 负责人: Kuldeepsinh Rana
• 金额: $ 31.72万
• 依托单位: FHC, INC.
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-02-25 至 2017-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8777770
• 关键词: Acute; Animal Experimentation; Animals; Brain; Cephalic; Characteristics; Clinic; Clinical; Communities; Data; Development; Dystonia; Electric Stimulation; Electromagnetics; Electrophysiology (science); Elements; Essential Tremor; Film; Funding; Gel; Goals; Heating; Human; Immune response; Inferior Colliculus; Life; Magnetic Resonance Imaging; Magnetism; Major Depressive Disorder; Marketing; Metals; Methods; Microelectrodes; Microscopic; Modeling; Modification; Nervous System Physiology; Neurons; Neurosciences; Neurosciences Research; Parkinson Disease; Pathway interactions; Patients; Performance; Phase; Physiologic pulse; Polymers; Preparation; Printing; Property; Publishing; Recording of previous events; Relative (related person); Research; Research Design; Research Personnel; Response Latencies; Rodent; Safety; Stimulus; Stroke; Surface; Synapses; System; Technology; Temperature; Testing; Therapeutic; Tissues; Transcranial magnetic stimulation; Translating; Work; absorption; base; biomaterial compatibility; brain tissue; clinical application; design; dorsal cochlear nucleus; improved; in vivo; instrument; magnetic field; nervous system disorder; neural circuit; neuronal circuitry; new technology; novel; pre-clinical; programs; prospective; prototype; public health relevance; response; simulation; success; systems research; tool; validation studies

DESCRIPTION (provided by applicant): We propose to evaluate the functionality, MRI- and bio-compatibility of probes for microscopic magnetic stimulation (mMS), a new brain stimulation technology. Moreover, it has been demonstrated that the orientation of the applied ¿MS fields (relative to the excitable tissue) provides unique activation of neuronal elements not seen with traditional electrical stimulation, a property that can be leveraged to improve experimental or therapeutic goals. This information will be used to develop a new product line for animal neuroscience research. These findings will provide a rationale for the further exploration of ¿MS as a prospective tool for clinical and preclinical applications which will be commercialized by FHC, a company with a 42-year history of successfully marketing to the research neuroscience market. The goal will be to further stimulate both development of ¿MS technology as well as the understanding of brain function.

描述（由应用程序提供）：我们建议评估有关微观磁刺激（MMS）的功能，MRI和生物兼容性，这是一种新的大脑刺激技术。此外，已经证明，所应用的„ MS领域的方向（相对于令人兴奋的组织）提供了对传统电刺激未见的神经元元素的独特激活，这是可以利用的特性来改善实验或治疗目标。该信息将用于开发动物神经科学研究的新产品系列。这些发现将为进一步探索“ MS作为临床和临床前应用的预期工具，这将提供一个理由，该工具将由FHC商业化。目的是进一步刺激MS技术的发展以及对大脑功能的理解。