Genetic Mechanisms and Evolution

遗传机制和进化

• 批准号: 10090376
• 负责人: John Novembre
• 金额: $ 78.02万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10090376
• 关键词: Evolution; Genetic

Recent technological advances have transformed genetics research, and social changes have caused major shifts in best practices for graduate education, research training, and mentoring. We propose an innovative interdisciplinary predoctoral T32 program, Genetic Mechanisms and Evolution (GME), which is specifically crafted to meet the challenges and opportunities presented by these changes. The GME program will train a diverse group of world-class Ph.D. scientists in molecular, statistical, and evolutionary genetics research who will serve as the next generation of innovative scientific leaders in genetics. Training will ensure development of multidisciplinary competence across these fields, with a strong foundation in quantitative and computational analysis for every student. The GME training program leverages the world-class strength of the University of Chicago in genetics. Mentors include 56 faculty with extraordinary records of research and graduate training, drawn from 14 departments across the fields of evolutionary, statistical, and molecular genetics. Further, the University’s unique organizational structure brings all areas of genetics into a single division and makes possible the interdisciplinary program we propose. Trainees for 18 funded positions will be selectively drawn from 9 graduate programs across disciplinary areas. The pool of potential trainees is extraordinarily well-qualified and diverse (49% women and 26% URM over the last 5 years). Trainees will be funded in years 2-3 of their studies, but they will participate in training and advising activities from matriculation through graduation. A new interdisciplinary core course and breadth requirements will develop student foundations in molecular, statistical, and evolutionary genetics and build strong skills in programming and statistics. Specialized workshops and an annual hackathon will provide further rigorous training in computational and quantitative analysis of modern genetic data. Formal writing instruction along with workshops in grant-writing and oral presentation skills will train scientists for effective communication and help ameliorate disparities in preparation among students from diverse backgrounds. Individual development plans, mentor-mentee contracts, faculty mentor training, and peer mentoring will facilitate trainee success and allow growth of a mutually supportive community of faculty and students. Participation in a pioneering career development program will support trainees in finding and preparing for a variety of post-PhD career paths. Recruitment and retention of an increasingly diverse group of students will be further strengthened by participating in pipeline and outreach programs, bridge activities for new students, and faculty training to enhance the inclusivity of the training environment and admissions process. All these activities -- building on the strengths of an exceptional cadre of trainees, trainers and institutional support – will allow us to recruit and train the future leaders of 21st century genetics research.

最近的技术进步已经改变了遗传学研究，社会变化也引起了重大的变化。 我们提出了一种创新的研究生教育、研究培训和指导最佳实践的转变。 跨学科博士前T32项目，遗传机制与进化（GME），专门 GME 计划旨在应对这些变化带来的挑战和机遇。 由分子、统计和进化遗传学领域的世界级博士科学家组成的多元化团队 研究人员将成为遗传学领域的下一代创新科学领导者。 确保在这些领域发展多学科能力，并在以下领域打下坚实的基础： 为每个学生进行定量和计算分析。 GME 培训项目充分利用了芝加哥大学在遗传学领域的世界级实力。 导师包括 56 名具有杰出研究和研究生培训记录的教师，他们来自 14 此外，该大学的院系涵盖进化、统计和分子遗传学领域。 独特的组织结构将遗传学的所有领域纳入一个部门，并使 我们提议的跨学科计划将有选择地从 9 个职位中挑选 18 个受资助职位的实习生。 跨学科领域的研究生课程。潜在的实习生库非常合格，而且 多元化（过去 5 年 49% 为女性，26% 为 URM）。 学员将在学习的第 2-3 年获得资助，但他们将参加培训和提供咨询 从入学到毕业的新的跨学科核心课程和广度要求。 将培养学生在分子、统计和进化遗传学方面的基础，并培养强大的技能 专业研讨会和年度黑客马拉松将提供进一步严格的指导。 现代遗传数据的计算和定量分析培训以及正式写作说明。 拨款写作和口头表达技巧研讨会将培训科学家进行有效的沟通和帮助 改善来自不同背景的学生在准备方面的差异，个人发展计划。 导师-受训者合同、教师导师培训和同伴指导将促进受训者的成功并允许 教师和学生相互支持的社区的成长参与开拓性的职业生涯。 发展计划将支持学员寻找并为各种博士后职业道路做好准备。 将进一步加强对日益多样化的学生群体的招募和保留 参与管道和外展计划、新生桥梁活动以及教师培训 所有这些活动都在此基础上增强培训环境和招生流程的包容性。 优秀的学员、培训师队伍和机构支持的优势——将使我们能够招募和 培养 21 世纪遗传学研究的未来领导者。