FEBio - Finite Elements for Biomechanics and Biophysics

FEBio - 生物力学和生物物理学的有限​​元

• 批准号: 8913201
• 负责人: GERARD A. ATESHIAN
• 金额: $ 30.28万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-30 至 2016-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8913201
• 关键词: Accounting; Action Potentials; Address; Algorithms; Area; Benchmarking; Beryllium; Binding; Biological; Biological Models; Biomechanics; Biophysics; Cardiovascular system; Cell Volumes; Chemicals; Code; Communication; Communities; Computational Science; Computer Simulation; Computer software; Custom; Development; Diagnosis; Disease; Elements; Energy Supply; Environment; Evolution; Funding; Growth; Investigation; Kinetics; Language; Letters; Life; Liquid substance; Manuals; Mechanics; Medical; Membrane; Membrane Potentials; Methodology; Methods; Modeling; Musculoskeletal; Nature; Nutrient; Progress Reports; Property; Public Domains; Publications; Regulation; Research; Research Personnel; Science; Solid; Solutions; Techniques; Technology; Testing; Thermodynamics; Time; Tissue Engineering; Tissues; base; biomechanical model; cell motility; chemical reaction; cost; design; dissemination research; expectation; improved; innovation; interest; interstitial; meetings; molecular dynamics; open source; operation; parallel processing; quality assurance; scaffold; solute; success; theories; tool; vector

DESCRIPTION (provided by applicant): Computational modeling in biomechanics has become a standard methodology, both for interpreting the biomechanical and biophysical basis of experimental results and as an investigative approach in its own right when experimental investigation is difficult or impossible. The finite element (FE) method is by far the most common numerical discretization and solution technique that has been used. However, the lack of a software environment that is tailored to the needs of the field has hampered research progress, dissemination of research and sharing of models and results. To address these issues, over the initial funding period, we developed FEBio, a nonlinear implicit FE framework designed specifically for analysis in biomechanics and biophysics. In this competing continuation application, we propose to considerably expand the capabilities of FEBio - to model the biomechanics and biophysics of living tissues by capitalizing on recent advances in the continuum mechanics of reactive mixtures. We also propose to broaden the target audience of FEBio by creating tools that facilitate interfacing with custom code. To help optimize the computational costs associated with these advanced modeling techniques, we also propose to extend the application of parallel processing in FEBio beyond the solver routines. Applications of computational biomechanics and biophysics span all fields of the biomedical sciences, including areas as diverse as molecular dynamics, cell motility and mechanics, cardiovascular mechanics, musculoskeletal biomechanics and tissue engineering. The FEBio software suite will facilitate advances in these fields, which in turn will contribute to improved understanding o basic biological and medical questions as well as improved strategies for diagnosis and treatment of disease.

描述（由申请人提供）：生物力学中的计算建模已成为一种标准方法，既可以解释实验结果的生物力学和生物物理基础，又是在实验研究困难或不可能时本身就是一种研究方法。有限元（Fe）方法是迄今为止使用的最常见数值离散和解决方案技术。但是，缺乏根据该领域需求量身定制的软件环境阻碍了研究的进度，研究以及模型和结果的共享。为了解决这些问题，在最初的资金期间，我们开发了Febio，这是一个专门用于生物力学和生物物理学分析的非线性隐式FE框架。在这种竞争性的连续应用中，我们建议通过利用反应性混合物的连续性力学的最新进步来大大扩展Febio的能力 - 为生物组织的生物力学和生物物理学建模。我们还建议通过创建有助于与自定义代码接口的工具来扩大Febio的目标受众。为了帮助优化与这些高级建模技术相关的计算成本，我们还建议将Febio中并行处理的应用范围扩展到求解器例程之外。计算生物力学和生物物理学的应用涵盖了生物医学科学的所有领域，包括分子动力学，细胞运动和力学，心血管力学，肌肉骨骼生物力学和组织工程等多样化的领域。 Febio软件套件将有助于这些领域的进步，这反过来又有助于改善理解o基本的生物学和医学问题以及改进的诊断和治疗疾病的策略。