Universal amplifier system for high-fidelity multi-modal biosignal recordings

用于高保真多模态生物信号记录的通用放大器系统

基本信息

批准号：
8991528
负责人：
William Combs
金额：
$ 4.68万
依托单位：
REFER2INPUT, LLC
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-09-01 至 2017-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8991528
关键词：
Address Algorithms Amplifiers Back Benchmarking Brain Businesses Calibration Cells Characteristics Clinical Communication Complex Computer software Coupled Data Data Collection Development Devices Diagnosis Digital Signal Processing Electrocardiogram Electrodes Electroencephalography Equipment Equipment Design Evolution Family suidae Frequencies Future Health Heart Implant Indiana Industry Intramuscular Laboratories Life Location Marketing Measurement Modeling Monitor Muscle Myocardium Nerve Tissue Noise Pathology Performance Peripheral Nerves Peripheral Nervous System Phase Physiological Play Preparation Process Questionnaires Relative (related person)Research Resolution Running Signal Transduction Skeletal Muscle Small Business Technology Transfer Research Smooth Muscle Source Structure Surface System Techniques Technology Telecommunications Testing Time Tissues Translating Universities Validation Voice analog base commercialization cost data visualization design digital electric impedance heart electrical activity improved in vivo instrumentation meetings miniaturize multi-electrode arrays neuroprosthesis novel prototype signal processing software systems success transmission process usability

项目摘要

DESCRIPTION (provided by applicant): The measurement, monitoring and use of bioelectric signals has evolved from the measurement of the electrical activity of the heart to encompass tissues ranging from cardiac, skeletal and smooth muscles, to brain and peripheral nerve tissues. Together with this development has been the evolution of specialized equipment to capture and interpret these minute signals. However, the future of bioelectric signals measurement is moving towards the measurement and integration of multiple sources, and multiple locations, which leads to the problem of the need to integrate signals and sources through specialized equipment designed for specific signals. To overcome this problem, Refer2Input (R2i) and its research partners at Indiana University Purdue University (IUPUI) designed novel bioelectric compander system following a reanalysis of the measurement and acquisition problem. The resulting Universal Invertible Amplifier system plays to the strengths of the analog and digital world to span the range of all bioelectric signals coupled with the ability o refocus to specific signals without hardware reconfiguration. In this STTR, R2i and its research partner at IUPUI will further develop this technology and demonstrate feasibility. Phase I Specific Aims are: 1) Develop and implement the hardware platform 2) Develop and implement the software platform and, 3) Complete in- vivo validation of the hardware and software system. The validated and tested UIA system will form the foundational instrumentation basis upon which a multi-modal, multi-frequency applications will be developed in Phase II. This system takes advantage of the universality of the hardware and the real-time refocus abilities of the UIA system, for which a considerable commercial market exists. The system will simplify the instrumentation needs of research and clinical laboratories, reducing costs through convergence to a single common recording platform.

描述（由申请人提供）：生物电信号的测量，监测和使用已经从对心脏的电活动的测量到涵盖从心脏，骨骼和平滑肌肉到脑和外周神经组织的组织。随着这一开发，专门设备的发展是捕获和解释这些微小信号的。但是，生物电信号测量的未来正在朝着测量和整合多个来源以及多个位置的趋势，这导致了需要通过为特定信号设计的专用设备集成信号和来源的问题。为了克服这个问题，Refer2 Input（R2I）及其在印第安纳大学普渡大学（IUPUI）的研究伙伴在重新分析测量和获取问题后设计了新颖的生物电容系统。由此产生的通用可逆放大器系统发挥了模拟和数字世界的优势，跨越了所有生物电信号的范围，并连接O重点的能力与没有硬件重新配置的特定信号。在此STTR中，R2I及其在IUPUI的研究合作伙伴将进一步开发这项技术并证明可行性。第一阶段的特定目的是：1）开发和实施硬件平台2）开发和实施软件平台，3）完成硬件和软件系统的体内验证。经过验证和测试的UIA系统将构成基础仪器基础，在II阶段将开发多模式的多频应用。该系统利用了硬件的通用性以及UIA系统的实时重新关注能力，并为其提供了相当大的商业市场。该系统将简化研究和临床实验室的仪器需求，从而通过收敛到单个共同记录平台来降低成本。