Arizona Department of Health Services FERN Chemistry Project

亚利桑那州卫生服务部 FERN 化学项目

• 批准号: 9095889
• 负责人: Jason Foster Mihalic
• 金额: $ 37.8万
• 依托单位: ARIZONA STATE DEPARTMENT OF HLTH SRVCS
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-01 至 2020-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9095889
• 关键词: Arizona; Department; Health; Services; FERN

AZDHS FERN Chemistry Project Project Summary The Arizona FERN Chemistry Program will utilize the GC/MS, LC/MS/MS, ICP- MS, ELISA, and IC-MS instrument platforms to continue with research projects started in the previous five-year grant cycle. Specifically inorganic work in a Level 3 multi-lab validation of EAM 4.7 Inductively Coupled Plasma – Mass Spectrometric (ICP-MS) and matrix expansion of the arsenic speciation methods EAM 4.10 and EAM 4.11. Ongoing organic projects include a Level 3 multi-lab validation of the T-022 version 9 Poison Screen using HPLC-MS, an instrument extension to CHE.0006.01 for using an Agilent 5977 GC/MS systems, and adding an amendment to CHE.0006.01 for use of hydrogen as a carrier gas instead of helium. In addition, the program proposes original research projects that will enhance the food safety and food defense capability and capacity of FERN. Specifically an instrument and analyte expansion of the T-034 Screen for Fluoroacetate, Azide, and Nitrite using Ion Chromatography Mass Spectrometry (IC-MS), the development of a GC-MS pesticide and endocrine disruptor screen utilizing deconvolution reporting software, the development of a qualitative high throughput screen for toxic metals with handheld X- Ray Fluorescence analyzers, the development of a high throughput method to screen for illegal food dyes, and the development of a method for speciation of chromium in food matrices. The program remains available to assist the FDA with surge capacity needs and will continue towards ISO-17025 accreditation.

AZDHS蕨化学项目 项目摘要 亚利桑那蕨化学计划将利用GC/MS，LC/MS/MS，ICP- MS，ELISA和IC-MS仪器平台继续进行研究项目 从上一年的赠款周期开始。特别是无机工作 3 EAM 4.7电感耦合等离子体的多LAB验证 - 质量 砷规范方法的光谱（ICP-MS）和基质扩展 EAM 4.10和EAM 4.11。正在进行的有机项目包括3级多lab 使用HPLC-MS（仪器）验证T-022版本9毒药屏幕 扩展到Che.0006.01使用Agilent 5977 GC/MS系统的扩展名，并添加 CHE.0006.01的修正案，用于使用氢作为载气而不是 氦。 此外，该计划提出的原始研究项目将增强 食品安全和食品防御能力和蕨类植物能力。特别是 氟乙酸酯，叠氮化物的T-034屏幕的仪器和分析物扩展 使用离子色谱质谱法（IC-MS）的亚硝酸盐， 使用GC-MS农药和内分泌破坏者屏幕的开发 反卷积的报告软件，定性高通量的开发 用手持X-Ray荧光分析仪筛选有毒金属， 开发高吞吐量方法以筛选非法食品染料，以及 开发食品材料中铬规格的方法。 该计划仍可以帮助FDA满足激增的能力需求和 将继续获得ISO-17025认证。