The Arizona Department of Health Services Food Safety and Food Defense Project

亚利桑那州卫生服务部食品安全和食品防护项目

• 批准号: 10461406
• 负责人: Jason Foster Mihalic
• 金额: $ 18.02万
• 依托单位: ARIZONA STATE DEPARTMENT OF HLTH SRVCS
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10461406
• 关键词: Arizona; Department; Health; Services; Food

Arizona Department of Health Services LFFM Grant Application Projects 1-7 Summary The Arizona Department of Health Services Laboratory (ASPHL) has capacity in Chemical, Microbiological, and Radiological testing to analyze food products for like contamination at both preparedness and regulatory levels. ASPHL is a FERN Laboratory under ISO 17025 accreditation for the analysis of food defense analytes and seeks to maintain that capability in both chemical and microbiological disciplines as well as expanding into radiochemical analysis for the duration of the 5-year project timeline. (CHEM / MICRO / RAD Tract 1). The ASPHL is the primary servicing laboratory for the testing of manufactured human food for the State of Arizona and seeks to introduce chemical food safety testing for metals and allergens on samples collected by state and county partners under the Manufactured Food Regulatory Program Standards (MFRPS) guidelines. (CHEM Tract 2). The ASPHL is partnered with Translational Genomics Research Laboratory (TGEN) for the yearly sequencing of 400 isolates of Salmonella, E. coli, Campylobacter and Listeria monocytogenes and will continue as a founding member of the FDA’s GenomeTrakr. Subrecipient TGEN has identified greater than 1000 isolates of target organisms to consider for whole genome sequencing on human food. (MICRO Tract 4). Method development is a strength of the ASPHL and the Chemistry Laboratory proposes to continue this activity with the development and validation of compliance level Allergen Testing using the MagPix System with XPonent 4.2 software with the end product being a written analytical method to submit to the FDA NPO for review. (CHEM Tract 4). The ASPHL FERN Chemistry is strong on metals analysis using ICP-MS and LC-ICP-MS and proposes to engage in a multi-laboratory validation of the Elemental Analysis manual method EAM 4.12: Analysis of Bottled Water by ICP-MS. The method will be validated two different ICP- MS platforms: an Agilent 7700 ICP-MS coupled to an Agilent 1200 uHPLC system and an Agilent 8900 ICP-triple quadruple-MS coupled with an Agilent 1260 infinity II. (CHEM SP D3).

亚利桑那州卫生服务部 LFFM 拨款申请项目 1-7 摘要 亚利桑那州卫生服务部实验室 (ASPHL) 具有化学、 微生物学和放射学测试，用于分析食品的类似污染情况 ASPHL 是 ISO 17025 下的 FERN 实验室。 食品防御分析师的分析认证，并力求在 化学和微生物学科以及扩展到放射化学分析 为期 5 年的项目时间表（CHEM / MICRO / RAD Tract 1）。 ASPHL 是测试人造食品的主要服务实验室 亚利桑那州并寻求引入金属和化学食品安全测试 州和县合作伙伴根据加工食品收集的样品中的过敏原 监管计划标准 (MFRPS) 指南（CHEM Tract 2）。 ASPHL 与转化基因组学研究实验室 (TGEN) 合作，致力于 每年对 400 个沙门氏菌、大肠杆菌、弯曲杆菌和李斯特菌分离株进行测序 单核细胞增多症，并将继续作为 FDA GenomeTrakr 的创始成员。 子受方 TGEN 已鉴定出超过 1000 个目标生物体分离株可供考虑 人类食品的全基因组测序（MICRO Tract 4）。 方法开发是 ASPHL 的强项，化学实验室建议 继续这项活动，开发和验证合规水平过敏原测试 使用 MagPix 系统和 XPonent 4.2 软件编写最终产品 提交给 FDA NPO 审查的分析方法（CHEM Tract 4）。 ASPHL FERN Chemistry 擅长使用 ICP-MS 和 LC-ICP-MS 进行金属分析， 建议对元素分析手动方法进行多实验室验证 EAM 4.12：通过 ICP-MS 分析瓶装水 该方法将通过两种不同的 ICP-MS 进行验证。 MS 平台：与 Agilent 1200 uHPLC 系统联用的 Agilent 7700 ICP-MS 和 Agilent 8900 ICP 三重四极杆 MS 与 Agilent 1260 infinity II (CHEM SP D3) 联用。