Toxicity Of Lead In Children--Clinical Trial

铅对儿童的毒性--临床试验

• 批准号: 8929710
• 负责人: WALTER ROGAN
• 金额: $ 25.88万
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8929710
• 关键词: Behavior; Blood specimen; Cadmium; Centers for Disease Control and Prevention (U.S.); Chelating Agents; Child; Clinical Trials; Cognition; Cognitive; Data; Defect; Enrollment; Lead; Lead Poisoning; Mercury; Oral; Poisoning; Reporting; Specimen; Succimer; Testing; Toddler; Toxic effect; chelation; design; prevent; randomized trial

We did a clinical trial of succimer to treat moderately lead poisoned children. We found no effect of succimer treatment on cognition or behavior, reported previously. Recently, we have arranged with CDC to analyze blood samples collected in this project for methyl mercury, inorganic mercury, and cadmium, which allowed a randomized trial of succimer for chelation of these compounds without enrolling any new subjects or collecting any specimens. Succimer does not appear to be an efficacious chelating agent for mercury or cadmium.

我们对婚姻进行了临床试验，以治疗中毒的中毒儿童。 先前报道，我们发现婚姻治疗对认知或行为没有影响。 最近，我们与CDC安排了该项目中收集的血液样本，用于甲基汞，无机汞和镉，该甲基汞，无机试验允许对这些化合物的螯合物进行随机试验，而无需注册任何新受试者或收集任何标本。 腐败似乎不是汞或镉的有效螯合剂。

项目成果

Prenatal exposure to perfluroalkyl substances and children's IQ: The Taiwan maternal and infant cohort study.

• DOI: 10.1016/j.ijheh.2015.07.002
• 发表时间: 2015-10
• 期刊: International journal of hygiene and environmental health
• 影响因子: 6
• 作者: Wang Y;Rogan WJ;Chen HY;Chen PC;Su PH;Chen HY;Wang SL
• 通讯作者: Wang SL

Postnatal cadmium exposure, neurodevelopment, and blood pressure in children at 2, 5, and 7 years of age.

• DOI: 10.1289/ehp.0900765
• 发表时间: 2009-10
• 期刊: Environmental health perspectives
• 影响因子: 10.4
• 作者: Cao Y;Chen A;Radcliffe J;Dietrich KN;Jones RL;Caldwell K;Rogan WJ
• 通讯作者: Rogan WJ