Building Capacity to study mixed metal-induced neurotoxicity in rural Bangladeshi children-A1

孟加拉国农村儿童研究混合金属引起的神经毒性的能力建设-A1

• 批准号: 10299709
• 负责人: Khalid M. Khan
• 金额: $ 57.51万
• 依托单位: SAM HOUSTON STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-14 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10299709
• 关键词: 2 year old; Accounting; Address; Adolescence; Adolescent; Affect; Age; Antibodies; Area; Arsenic; Bangladesh; Bangladeshi; Behavior assessment; Behavioral Research; Biological Markers; Biometry; Blood; Blood specimen; Brain; Cadmium; Child; Child Development; Childhood; Collaborations; Country; Data; Data Analyses; Development; Economic Development; Economics; Educational workshop; Environmental Pollutants; Environmental Pollution; Environmental Risk Factor; Epidemiologist; Epidemiology; Etiology; Evaluation; Exposure to; Faculty; First Pregnancy Trimester; Goals; Health; Impairment; Individual; Infant; Institutes; Iodide Peroxidase; Iodine; Iowa; Knowledge; Laboratories; Lead; Life; Link; Longitudinal cohort study; Manganese; Manuscripts; Measures; Mediating; Medical; Medicine; Metal exposure; Metals; Modeling; Mothers; Neurocognitive; Neurocognitive Deficit; Neuroepidemiology; Neurologic; Outcome; Performance; Phase; Population; Preparation; Property; Public Health; Research; Research Infrastructure; Research Institute; Research Methodology; Research Personnel; Risk; Rural; Scientist; Serum; Social Development; Standardization; System; Testing; Thyroglobulin antibody; Thyroid Diseases; Thyroid Gland; Thyroid Hormones; Thyrotropin; Thyroxine; Toddler; Toxic effect; Training; Triiodothyronine; Universities; Writing; adolescent health; brain health; brain research; career; college; diarrheal disease; disability-adjusted life years; early pregnancy; epidemiologic data; epidemiology study; high risk; improved; international center; low and middle-income countries; maternal serum; nervous system disorder; neurobehavioral; neurodevelopment; neuroimaging; neurotoxicity; novel; prenatal; programs; recruit; research study; rural area; skills; symposium; systems research; thyroid disruption; tool; toxic metal; urinary; virtual; webinar

PROJECT SUMMARY The economic and public health burden of neurological diseases are remarkably high in Bangladesh with 5,344 cases per 100,000 people. Yet, the etiology of neurological disorders with respect to environmental pollutants, particularly toxic metals such as arsenic (As), lead (Pb), manganese (Mn), and cadmium (Cd), is poorly understood. These metals co-exist at moderate to high levels posing additional risk to children. Recent Bangladesh studies, including our own, have shown neurobehavioral (NB) effects associated with single metal exposure in children living in the rural areas. These detrimental effects, often subtle, potentially have long-term impact on the educational, social, and economic development of the population. This is, in part, due to the limited research capacity of local Bangladeshi researchers to properly evaluate the impact of mixed metal-induced impairment on brain function. To address this fundamental gap in critical research capacity, we plan to improve the research skills of Bangladeshi scientists by providing them the necessary training to appropriately investigate children’s brain vulnerability induced by metal co-exposure. The proposed study has assembled a group of U.S. investigators from Sam Houston State University, Columbia University, the University of Houston, Baylor College of Medicine, and the University of Iowa. The U.S. scientists will collaborate with the Bangladeshi researchers and faculty from the International Center for Diarrheal Disease Research, Bangladesh (icddr,b), Bangabandhu Sheikh Mujib Medical University (BSMMU), the largest medical university in Bangladesh, and North South University (NSU). Our goal is to improve the research capacity of scientists and clinicians by (i) organizing in-country and virtual yearly workshops/training and symposia on neuro-epidemiological research methodology and manuscript preparation; (ii) providing within the U.S. (and virtually), training on various neurobehavioral (NB) evaluation tools and data analysis; and (iii) involving the local researchers in two proposed epidemiological studies to be conducted in Bangladesh. In the first study, 600 adolescents from the Health Effects of Arsenic Longitudinal Study (HEALS) cohort in Araihazar will be evaluated for NB performance. Concurrently, adolescent blood samples will be analyzed for metals and thyroid hormone (TH) since metals are known to disrupt TH prenatally leading to poor NB performance in childhood. Free thyroxine (fT4), total triiodothyronine (tT3), thyroid stimulating hormone (TSH), thyroid peroxidase antibody (TPOAb), and thyroglobulin antibody (TgAb) will be analyzed. The Behavioral Assessment and Research System (BARS) battery will be used for NB assessment. The second study will recruit 200 mother-child pairs from the Health and Demographic Surveillance System (HDSS) area in Matlab to assess if maternal metal mixture exposure is associated with TH disruption in early pregnancy, and in turn, if prenatal disruption of TH interferes with NB performance in young children. Together, these two studies will test if metal- induced neurotoxicity in early life, in part, mediate the relationships between metal co-exposure and NB.

项目摘要 孟加拉国的神经系统疾病的经济和公共卫生烧伤非常高，有5,344 每10万人的案件。然而，关于环境污染物的神经系统疾病的病因， 特别是有毒金属，例如砷（AS），铅（PB），锰（MN）和镉（CD），较差 理解齿。这些金属以中等至高水平的身份共存，对儿童构成额外的风险。最近的 孟加拉国的研究，包括我们自己的研究，显示了与单金属相关的神经行为（NB）效应 居住在粗糙地区的儿童的暴露。这些有害影响，通常是微妙的，可能具有长期 对人口的教育，社会和经济发展的影响。这部分是由于有限的 当地孟加拉国研究人员的研究能力正确评估了混合金属引起的影响 大脑功能受损。为了解决关键研究能力的这一基本差距，我们计划改善 孟加拉国科学家的研究技能通过为他们提供必要的培训来适当调查 金属共暴露引起的儿童大脑脆弱性。 拟议的研究已汇集了来自萨姆·休斯顿州立大学的一群美国调查员 哥伦比亚大学，休斯顿大学，贝勒医学院和爱荷华大学。美国 科学家将与国际腹泻中心的孟加拉国研究人员和教职员工合作 孟加拉国疾病研究（ICDDR，B），Bangabandhu Sheikh Mujib医科大学（BSMMU），最大的 孟加拉国的医科大学和北南大学（NSU）。我们的目标是改善研究 科学家和临床医生的能力（i）组织国内和虚拟的年度研讨会/培训以及 关于神经 - 流行病学研究方法和手稿准备的研讨会； （ii）提供 美国（实际上），关于各种神经行为（NB）评估工具和数据分析的培训； （iii）涉及 在两项拟议的流行病学研究中，当地研究人员将在孟加拉国进行。 在第一项研究中，砷纵向研究（HELS）队列的健康影响的600名青少年 Araihazar将评估NB性能。同时，将分析青少年血液样本 金属和甲状腺马酮（TH），因为已知金属会破坏产前，导致NB不良 童年的表现。游离甲状腺素（FT4），总三碘甲氨酸（TT3），甲状腺刺激骑马（TSH）， 将分析甲状腺过氧化物酶抗体（TPOAB）和甲状腺球蛋白抗体（TGAB）。行为 评估和研究系统（BAR）电池将用于NB评估。第二项研究将招募 来自MATLAB的健康与人口监视系统（HDSS）区域的200个母子对 如果母体金属混合物暴露与怀孕初期的破坏有关 破坏了幼儿NB表现的干扰。这两项研究一起测试金属是否 早期诱导的神经毒性部分介导了金属共暴露与NB之间的关系。