Tissue Management Shared Resource

组织管理共享资源

• 批准号: 10260741
• 负责人: Adam Yopp
• 金额: $ 57.05万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-03 至 2021-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10260741
• 关键词: African American; Anatomy; Biological Markers; Bladder; Blood; Bone Marrow; Breast; Cancer Center; Cancer Center Support Grant; Caucasians; Clinical; Clinical Cancer Center; Clinical Data; Clinical Research; Clinical and Translational Science Awards; Colon; Computerized Medical Record; Consent; Data; Data Collection; Database Management Systems; Databases; Development; Disease; Environment; Equipment; Female; Genetic; Genetic Databases; Genomics; Goals; Growth; Hispanics; Human; Infrastructure; Institutional Review Boards; Ischemia; Kidney; Laboratory Finding; Link; Liquid substance; Location; Lung; Malignant Neoplasms; Medical center; Monitor; Pancreas; Participant; Pathologic; Pathology; Pleural; Prostate; Proteins; Proteomics; Protocols documentation; Reaction; Research; Research Activity; Research Personnel; Resource Sharing; Resources; Sampling; Secure; Services; Specimen; Technology; Time; Tissue Banks; Tissue Procurements; Tissue Sample; Tissues; Translational Research; Universities; Update; Urine; Validation; base; biomarker panel; cancer type; central database; data warehouse; database query; demographics; innovation; interest; member; metabolomics; outcome forecast; tool; translational medicine; tumor; tumor registry; web interface

Harold C. Simmons Cancer Center Tissue Management Shared Resource (Translational Research Resource) Project Summary/Abstract The Tissue Management Shared Resource was established in 2004 to provide IRB-approved centralized tissue procurement services for specimens derived from consented human participants. Over 22,000 tissue specimens and bodily fluids, from over 50 different tissue types including breast, lung, prostate, kidney, bladder, colon, pancreas, blood, pleural fluid, urine and bone marrow have been collected since its establishment. In terms of demographics, specimens were obtained from Caucasian (72%), African-American (24%) and Hispanic participants (16%). Of the tissues collected, 56% of specimens are derived from female participants. Although the basic functions and goals of the Tissue Management Shared Resource remain essentially unchanged, the capabilities of the facility have been significantly expanded to support the growing needs of Simmons Cancer Center members and facilitate translational research activities. To facilitate this growth, Tissue Management Shared Resource has moved to a new location that provides additional space for equipment and staff. The equipment has been updated to accommodate increased and changing research needs. Additionally, tissue banking and annotation of specimens has been extensively expanded. Specimen related data are captured and stored in our tissue management database, caTissue Plus, and are correlated with clinical information through the Simmons Cancer Center's clinical research data warehouse (i2b2) as part of the UTSW Center for Translational Medicine (CTM), which is the institutional CTSA (Clinical & Translational Science Award). This tool links caTissue Plus data with EPIC Clarity (the electronic medical record), Oncolog (the university tumor registry database), CoPath (the anatomical pathology database), CancerGeneConnect (the familial genetics database) and other disease-specific databases. Due to this robust infrastructure, biospecimens are automatically annotated with demographic, pathological, and clinical data so that interested investigators can perform basic sample availability queries of this database in a de-identified manner through a secure web interface.

哈罗德·西蒙斯癌症中心 组织管理共享资源（转化研究资源） 项目概要/摘要 组织管理共享资源成立于 2004 年，旨在提供经 IRB 批准的集中管理 为来自同意的人类参与者的标本提供组织采购服务。超过 22,000 张纸巾 来自 50 多种不同组织类型的样本和体液，包括乳腺、肺、前列腺、肾、 自其开始收集膀胱、结肠、胰腺、血液、胸水、尿液和骨髓 设立。就人口统计而言，样本来自白种人（72%）、非洲裔美国人 (24%) 和西班牙裔参与者 (16%)。在收集的组织中，56%的标本来自女性 参与者。尽管组织管理共享资源的基本功能和目标仍然存在 基本没有变化，该设施的能力得到了显着扩展，以支持不断增长的 西蒙斯癌症中心成员的需求并促进转化研究活动。为了促进这一点 随着组织管理共享资源的增长，组织管理共享资源已移至新位置，为 设备和人员。设备已更新，以适应增加和变化的研究 需要。此外，组织库和标本注释也得到了广泛扩展。标本 相关数据被捕获并存储在我们的组织管理数据库 caTissue Plus 中，并且相互关联 通过西蒙斯癌症中心的临床研究数据仓库 (i2b2) 获取临床信息 UTSW 转化医学中心 (CTM) 的机构，该中心是 CTSA（临床与转化医学）机构 科学奖）。该工具将 caTissue Plus 数据与 EPIC Clarity（电子病历）、Oncolog 连接起来 （大学肿瘤登记数据库）、CoPath（解剖病理学数据库）、CancerGeneConnect （家族遗传学数据库）和其他特定疾病数据库。由于这个强大的基础设施， 生物样本会自动标注人口统计、病理和临床数据，以便感兴趣的人 调查人员可以通过去识别化的方式对该数据库执行基本的样本可用性查询 安全的网络界面。