Tissue Management Shared Resource

组织管理共享资源

基本信息

批准号：
10693250
负责人：
Adam Yopp
金额：
$ 40.1万
依托单位：
UT SOUTHWESTERN MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-09-01 至 2026-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10693250
关键词：
Academia Animal Model Asian Biological Markers Black race Bladder Blood Blood specimen Body Fluids Bone Marrow Breast Cancer Center Support Grant Cell Culture Techniques Cell Line Cells Center for Translational Science Activities Clinical Clinical Data Collaborations Colon Comprehensive Cancer Center Computerized Medical Record Consent Consultations Cryopreserved Tissue Custom DNA Data Databases Dedications Evaluation Feedback Female Formalin Freezing Funding Genomics Goals Grant Hispanic Histology Human Image Analysis Immunohistochemistry Immunology Industry Infrastructure Intranet Journals Kidney Leadership Liquid substance Lung Malignant Neoplasms Malignant neoplasm of lung Medical center Medicine Methodology Molecular Mus NCI Center for Cancer Research National Cancer Institute Nature Normal tissue morphology Not Hispanic or Latino Online Systems Pancreas Participant Pathologic Pathologist Pathology Peer Review Plasma Pleural Primary carcinoma of the liver cells Principal Investigator Prostate Publications Publishing Quality Control RNA Renal carcinoma Research Research Personnel Research Project Grants Resource Sharing Resources Sampling Science Serum Services Signal Transduction Specialized Program of Research Excellence Specimen Stomach Surveys Time Tissue Banks Tissue Microarray Tissue Procurements Tissues Tumor Cell Line Tumor Tissue Urine Work biobank cancer cell human model innovation insight melanoma member preservation programs prospective response searchable database success tissue fixing tumor tumor registry web interface web portal whole slide imaging

项目摘要

The goals of Simmons Comprehensive Cancer Center (SCCC) Tissue Management Shared Resource (TMSR) are to facilitate the storage and distribution of comprehensively annotated, high-quality biospecimens and their derivatives and to provide professional and technical pathology services to investigators and collaborators within and outside of SCCC. Under the leadership of Adam Yopp, MD, the TMSR delivers basic histomorphological evaluation of human tumors and human tumor grafts in mice, as well as basic and advanced immunohistochemistry (IHC) services, creates custom tissue microarrays (TMA), and provides whole slide imaging and image analysis. In addition, the TMSR offers unique cancer-tissue derivatives such as primary cancer cell cultures and cell lines, cryopreserved tissues, DNA, and RNA. The TMSR currently has greater than 37,000 fresh frozen tissues and 42,000 formalin-fixed tissues, as well as clinically annotated TMAs with paired tumor and normal tissue from the following malignancies: breast, hepatocellular carcinoma, colon, lung, melanoma, gastric, and pancreas. In addition, the TMSR currently has greater than 42,000 serum and plasma blood samples and 8,000 buffy coat samples. Samples are listed in an annotated and searchable database that is available to SCCC members through the intranet. The TMSR provides routine quality controls for all prospectively consented collected specimens. The TMSR has had significant utilization, with greater than 3,500 samples having been distributed to investigators internally and externally in 2019. The TMSR promotes flourishing collaborations among SCCC investigators, investigators from other National Cancer Institute (NCI)- designated Comprehensive Cancer Centers, and other investigators in academia and industry. The services of the TMSR were utilized by 78 investigators across five SCCC Research Programs in 2019, providing key data and insights to support the success of NCI-funded research grants, including the lung and kidney cancer SPORE grants and 115 peer-reviewed publications, with work published in high-impact journals such as JCI, Cancer Discovery, Science Signaling, Science Immunology, Nature, and Nature Medicine. Over the current cycle, the TMSR had over a 100% increase in its usage due to rapid response to investigator needs and SCCC priorities.

西蒙斯综合癌症中心 (SCCC) 组织管理共享资源 (TMSR) 的目标旨在促进全面注释的高质量生物样本及其存储和分发衍生品，并为研究人员和合作者提供专业和技术病理学服务以及 SCCC 之外。在医学博士 Adam Yopp 的领导下，TMSR 提供了基本的组织形态学信息人类肿瘤和小鼠人类肿瘤移植物的评估，以及基础和高级免疫组织化学 (IHC) 服务，创建定制组织微阵列 (TMA)，并提供整个载玻片成像和图像分析。此外，TMSR 还提供独特的癌症组织衍生物，例如原发性癌细胞培养物和细胞系、冷冻组织、DNA 和 RNA。目前 TMSR 已超过 37,000 个新鲜冷冻组织和 42,000 个福尔马林固定组织，以及带有配对的临床注释 TMA 来自以下恶性肿瘤的肿瘤和正常组织：乳腺癌、肝细胞癌、结肠癌、肺癌、黑色素瘤、胃和胰腺。此外，TMSR目前拥有超过42,000份血清和血浆血液样本和 8,000 个血沉棕黄层样本。样本列在带注释且可搜索的数据库中， SCCC 会员可以通过内联网访问。 TMSR 为所有人员提供常规质量控制前瞻性同意收集的标本。 TMSR 的利用率很高，超过 3,500 样本已于 2019 年分发给内部和外部调查人员。TMSR 促进 SCCC 研究人员与其他国家癌症研究所 (NCI) 的研究人员之间的蓬勃合作 - 指定的综合癌症中心以及学术界和工业界的其他研究人员。的服务 2019 年，五个 SCCC 研究项目的 78 名研究人员使用了 TMSR，提供了关键数据支持 NCI 资助的研究经费（包括肺癌和肾癌 SPORE）取得成功的见解和见解资助和 115 篇同行评审出版物，其作品发表在 JCI、Cancer 等高影响力期刊上发现、科学信号、科学免疫学、自然和自然医学。在当前周期内，由于对研究者需求和 SCCC 优先事项的快速响应，TMSR 的使用量增加了 100% 以上。