Mentored Patient Oriented Research in ARDS and Critical Illness Outcomes

指导 ARDS 和危重疾病结果中以患者为导向的研究

基本信息

批准号：
10249623
负责人：
Catherine Lee Hough
金额：
$ 11.86万
依托单位：
OREGON HEALTH & SCIENCE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-08-01 至 2024-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10249623
关键词：
Acute Admission activity Adult Respiratory Distress Syndrome Affect Area Award Biology Cessation of life Chest Chronic Clinical Clinical Data Clinical Trials Communities Conduct Clinical Trials Critical Care Critical Illness Data Development Development Plans Disease Distress Educational workshop Electrophysiology (science)Enrollment Environment Epidemiologic Methods Etiology Faculty Family Funding Future Goals Health Health Services Research Health Status Hospital Mortality Image Impairment Infrastructure Injury Intervention Intervention Studies Knowledge Leadership Learning Lung Measures Mechanical ventilation Medicine Mentors Mentorship Methods Mid-Career Clinical Scientist Award (K24)Midcareer Investigator Award in Patient-Oriented Research Morbidity - disease rate Muscle Muscle function National Heart, Lung, and Blood Institute Observational Study Online Systems Outcome Outcome Study Patient Education Patient-Focused Outcomes Patients Personal Satisfaction Persons Phenotype Physical Function Play Postdoctoral Fellow Principal Investigator Prospective cohort Proxy Recovery Research Research Methodology Research Personnel Research Project Grants Resources Risk Risk Factors Role Scanning Science Scientist Sleep Structure Survivors Techniques Time Training Universities Washington Work X-Ray Computed Tomography abdominal CT career career development clinical care clinical epidemiology clinical practice cohort comorbidity design disability disability burden functional disability health care service utilization health related quality of life improved improved outcome innovation mentoring community mindfulness intervention mortality muscle form muscle strength neuromuscular novel outcome prediction patient oriented patient oriented research programs prospective randomized trial reduced muscle mass research and development sarcopenia skills student mentoring success successful intervention

项目摘要

PROJECT SUMMARY/ABSTRACT The goal of this Midcareer Investigator Award in Patient Oriented Research is to provide key mentorship, resources and protected time to strengthen Dr. Catherine Hough's success in mentoring students, post- doctoral fellows and junior faculty in the science of patient-centered outcomes after the acute illness and injury, with a focus on the acute respiratory distress syndrome and critical illness. Although hospital mortality after critical illness has improved significantly over the past decades, there is increasing recognition that recovery is incomplete, with a substantial burden of disability and impairments in function and health-related quality of life among ICU survivors. Interventions to improve these patient-centered outcomes have been largely unsuccessful, and understanding of the mechanisms of post-ICU impairments remains quite limited. Recently, there has been increased recognition that pre-morbid health and disability are significant contributors to post- ICU impairment and to the heterogeneous trajectories of recovery, but research and clinical practice have been stalled by the difficulty of assessing pre-morbid factors at the time of ICU admission. Moving the field forward will require innovative approaches to phenotyping patients using clinical data and techniques from clinical epidemiology and health services research. Dr. Hough is an ideal candidate to provide mentorship in this area. She is a mid-career investigator with expertise in observational and interventional studies of outcomes after ARDS and critical illness, and she has a strong and growing track record in successful mentorship in patient- oriented research as well as a strong existing research program. In this award, Dr. Hough will enhance and advance her career in three ways. She will participate in structured activities to develop her mentoring skills, including one-on-one sessions with Dr. Randy Curtis, local in-person workshops and national web-based programs. She will gain content knowledge on muscle biology, use of computed tomography images in assessing muscle mass and quality. Additionally, she will work with methods experts to learn to incorporate clinical and administrative data of co-morbidity and health-care utilization into developing phenotypes of premorbid disease that predict disability and recovery. The scientific goal of this project is to investigate the relationship between premorbid muscle mass and quality, assessed via analysis of existing computed tomography scans, and short and long-term outcomes after critical illness, including muscle strength, function and disability. This project will leverage two ongoing R01-funded prospective cohorts for which Dr. Hough is a PI which contain detailed assessment of co-morbidities and pre-morbid health care utilization, prospective assessments of muscle strength and function during and after critical illness, and will create new opportunities for mentored research. Dr. Hough's career development and scientific aims will provide an outstanding environment for training of patient-oriented researchers focused on improving outcomes after critical illness.

项目概要/摘要该以患者为导向的研究中的职业中期研究员奖的目标是提供关键指导，资源和受保护的时间，以加强凯瑟琳·霍夫博士在指导学生、毕业后的成功急性疾病和损伤后以患者为中心的结果科学领域的博士研究员和初级教师，重点关注急性呼吸窘迫综合征和危重疾病。尽管住院后死亡率过去几十年来，危重疾病已得到显着改善，人们越来越认识到康复是关键不完整，具有严重的残疾负担以及功能和健康相关生活质量受损 ICU 幸存者中。改善这些以患者为中心的结果的干预措施在很大程度上是不成功，而且对 ICU 后损伤机制的了解仍然相当有限。最近，人们越来越认识到，病前健康和残疾是病后的重要因素。 ICU 损伤和恢复轨迹的异质性，但研究和临床实践已经由于在入住 ICU 时评估病前因素的困难而陷入停滞。推动该领域向前发展将需要使用来自临床的临床数据和技术对患者进行表型分型的创新方法流行病学和卫生服务研究。霍夫博士是在该领域提供指导的理想人选。她是一名职业中期调查员，在术后结果的观察和干预研究方面拥有专业知识。 ARDS 和危重疾病，她在成功指导患者方面拥有良好且不断增长的记录—— 定向研究以及强大的现有研究计划。在这个奖项中，霍夫博士将加强和通过三种方式推进她的职业生涯。她将参加结构化活动来发展她的指导技能，包括与 Randy Curtis 博士的一对一会议、当地面对面研讨会和全国网络研讨会程序。她将获得有关肌肉生物学、计算机断层扫描图像的使用的内容知识评估肌肉质量和质量。此外，她将与方法专家合作，学习如何将将共病和医疗保健利用的临床和管理数据转化为发展表型预测残疾和康复的病前疾病。该项目的科学目标是研究病前肌肉质量和质量之间的关系，通过分析现有的计算结果进行评估断层扫描以及危重病后的短期和长期结果，包括肌肉力量、功能和残疾。该项目将利用两个正在进行的 R01 资助的前瞻性队列，Hough 博士是其中的一名成员 PI，其中包含对合并症和病前医疗保健利用的详细评估、前瞻性评估危重疾病期间和之后的肌肉力量和功能，并将创造新的机会用于指导研究。霍夫博士的职业发展和科学目标将为他提供杰出的以患者为中心的研究人员的培训环境，重点是改善危重病后的结果。