Pacific Northwest Clinical Center for the NHLBI PETAL Network

NHLBI PETAL 网络西北太平洋临床中心

基本信息

批准号：
10225213
负责人：
Catherine Lee Hough
金额：
$ 32.66万
依托单位：
OREGON HEALTH & SCIENCE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-08-01 至 2021-10-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10225213
关键词：
Accident and Emergency department Acute Lung Injury Adult Respiratory Distress Syndrome Biological Biology Caring Clinical Clinical Data Clinical Management Clinical Research Clinical Trials Clinical Trials Network Community Hospitals Computerized Medical Record Conduct Clinical Trials Critical Care Critical Illness Data Collection Drops Early treatment Emergency Medicine Epidemiologist Epidemiology Future Goals Health Hospitals Hypoxemia Impairment Incidence Information Technology Injury Institution Intervention Intervention Studies Investigation Liquid substance Monitor Morbidity - disease rate Multi-Institutional Clinical Trial National Heart, Lung, and Blood Institute Operative Surgical Procedures Oregon Outcome Pacific Northwest Pathogenesis Patient-Focused Outcomes Patients Pharmacology Prevention Protocols documentation Publications Quality Control Quality of life Randomized Controlled Clinical Trials Randomized Controlled Trials Recovery Research Research Personnel Resources Respiratory Failure Risk Safety Sampling Science Scientist Specialist Specimen Survivors System Testing Therapy Clinical Trials Tidal Volume Trauma Ventilator Washington Work clinical center clinical data warehouse collaborative approach design disease phenotype experience high risk improved improved outcome interdisciplinary approach molecular phenotype mortality multidisciplinary novel novel therapeutics patient subsets prevent protocol development public health relevance recruit repository response screening success ventilation ward

项目摘要

DESCRIPTION (provided by applicant): The goal of the Prevention and Early Treatment of Acute Lung Injury (PETAL) Network is to develop and conduct high-quality randomized, controlled clinical trials to prevent, treat and/or improve outcomes of patients with or at risk fo acute respiratory distress syndrome (ARDS) using a multidisciplinary and collaborative approach, and to collect biologic samples and clinical data necessary to determine the molecular phenotype of disease pathogenesis, response to therapy, and recovery. The specific objective of the Pacific Northwest Clinical Center is to participate in this clinical network in orer to expand upon the work we have done through the two previous ARDS Clinical Trials Networks since 1994. ARDS is a form of hypoxemic respiratory failure that is common, often fatal, and associated with significant sequelae that have a long lasting impact on the health and quality of life of its survivors. While previous trials of pharmacologic agents have failed to decrease mortality of patients with ARDS, the first two NHLBI ARDS Networks have demonstrated that changes in ventilator and fluid management can profoundly improve patient outcome. Since the publication of the landmark study of low tidal volume ventilation in 2000, there has been a steady drop in the case fatality of ARDS. The preceding NHLBI ARDS Networks proved the hypothesis that an investigator-directed network of clinical and research centers can design and conduct investigations that would improve outcomes for patients with ARDS. By expanding the focus beyond the ICU, this new network has the potential to be even more far- reaching. The proposed Pacific Northwest Clinical Center embodies the experienced, diverse, collaborative and multidisciplinary approach that will lead to PETAL's success. We are a team of academic and community hospitals; of critical care, trauma/surgical and emergency medicine specialists; and of clinical trialists, basic scientists; epidemiologists, clinicians, and research coordinators, in both Seattle, Washington and Portland, Oregon. We believe that the opportunity to improve care and both short and long-term outcomes of critically ill patients is in the hands of this new PETAL Network. In this application, we will demonstrate why the Pacific Northwest Clinical Center will be an important part of this new Network's success.

描述（由申请人提供）：急性肺损伤预防和早期治疗 (PETAL) 网络的目标是开发和开展高质量的随机对照临床试验，以预防、治疗和/或改善患有急性肺损伤的患者的预后。使用多学科和协作方法来评估急性呼吸窘迫综合征（ARDS）的风险，并收集确定疾病发病机制的分子表型、治疗反应和恢复所需的生物样本和临床数据。太平洋西北临床中心的具体目标是参与该临床网络，以扩展我们自 1994 年以来通过前两个 ARDS 临床试验网络所做的工作。 ARDS 是低氧血症性呼吸衰竭的一种形式，很常见，通常是致命的，并伴有严重的后遗症，对其幸存者的健康和生活质量产生长期持续的影响。虽然之前的药物试验未能降低 ARDS 患者的死亡率，但前两个 NHLBI ARDS 网络已证明呼吸机和液体管理的改变可以深刻改善患者的预后。自 2000 年发表具有里程碑意义的低潮气量通气研究以来，ARDS 的病死率一直在稳步下降。之前的 NHLBI ARDS 网络证明了这样的假设：由研究者指导的临床和研究中心网络可以设计和开展能够改善 ARDS 患者预后的调查。通过将重点扩展到 ICU 之外，这个新网络有可能影响更加深远。拟议的太平洋西北临床中心体现了经验丰富、多样化、协作和多学科的方法，这将导致 PETAL 的成功。我们是一个由学术和社区医院组成的团队；重症监护、创伤/外科和急诊医学专家；和临床试验人员的基本科学家；华盛顿州西雅图和俄勒冈州波特兰的流行病学家、临床医生和研究协调员。我们相信，改善危重患者的护理以及短期和长期结果的机会掌握在这个新的 PETAL 网络手中。在此应用程序中，我们将展示为什么太平洋西北临床中心将成为这个新网络成功的重要组成部分。

项目成果

期刊论文数量（5）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Patients' Adaptations After Acute Respiratory Distress Syndrome: A Qualitative Study.

急性呼吸窘迫综合征后患者的适应：一项定性研究。

DOI：
发表时间：
2021
期刊：
影响因子：
0
作者：
Hauschildt, Katrina E;Seigworth, Claire;Kamphuis, Lee A;Hough, Catherine L;Moss, Marc;McPeake, Joanne M;Harrod, Molly;Iwashyna, Theodore J
通讯作者：
Iwashyna, Theodore J

Recall of clinical trial participation and attrition rates in survivors of acute respiratory distress syndrome.

回顾急性呼吸窘迫综合征幸存者的临床试验参与率和损耗率。

DOI：
发表时间：
2021-08
期刊：
影响因子：
3.7
作者：
Carlton, Erin F;Ice, Erin;Barbaro, Ryan P;Kampuis, Lee;Moss, Marc;Angus, Derek C;Banner;Ginde, Adit A;Gong, Michelle N;Grissom, Colin K;Hou, Peter C;Huang, David T;Hough, Catherine Terri Lee;Talmor, Daniel S;Thompson, B
通讯作者：
Thompson, B

Continuing Cardiopulmonary Symptoms, Disability, and Financial Toxicity 1 Month After Hospitalization for Third-Wave COVID-19: Early Results From a US Nationwide Cohort.

第三波 COVID-19 住院 1 个月后持续心肺症状、残疾和财务毒性：来自美国全国队列的早期结果。

DOI：
发表时间：
2021-08-18
期刊：
影响因子：
0
作者：
Iwashyna, Theodore J;Kamphuis, Lee A;Gundel, Stephanie J;Hope, Aluko A;Jolley, Sarah;Admon, Andrew J;Caldwell, Ellen;Monahan, Max L;Hauschildt, Katherine;Thompson, B Taylor;Hough, Catherine L;NHLBI Prevention and Early Treatment of Acute Lung I
通讯作者：
NHLBI Prevention and Early Treatment of Acute Lung I

The acute respiratory distress syndrome after out-of-hospital cardiac arrest: Incidence, risk factors, and outcomes.

院外心脏骤停后的急性呼吸窘迫综合征：发生率、危险因素和结果。

DOI：
发表时间：
2019
期刊：
影响因子：
6.5
作者：
Johnson, Nicholas J;Caldwell, Ellen;Carlbom, David J;Gaieski, David F;Prekker, Matthew E;Rea, Thomas D;Sayre, Michael;Hough, Catherine L
通讯作者：
Hough, Catherine L

Targeted Temperature Management at 33 Versus 36 Degrees: A Retrospective Cohort Study.

33 度与 36 度的目标温度管理：一项回顾性队列研究。

DOI：
发表时间：
2020
期刊：
影响因子：
8.8
作者：
Johnson, Nicholas J;Danielson, Kyle R;Counts, Catherine R;Ruark, Katelyn;Scruggs, Sue;Hough, Catherine L;Maynard, Charles;Sayre, Michael R;Carlbom, David J
通讯作者：
Carlbom, David J