ABCD-USA Consortium: Coordinating Center

ABCD-美国联盟：协调中心

基本信息

批准号：
9054658
负责人：
SANDRA A BROWN
金额：
$ 189.98万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-09-30 至 2020-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9054658
关键词：
10 year old Address Adherence Adolescence Adolescent Adolescent Development Alcohol or Other Drugs use Alcohols American Area Behavioral Behavioral Genetics Benchmarking Bioinformatics Biological Biological Assay Brain Child Child Development Child health care Childhood Communication Communities Data Data Analyses Data Collection Data Quality Databases Development Disputes Drug abuse Drug usage Emotional Ensure Environment Epidemiology Ethics Event Functional disorder Future Genetic Goals Human Human Development Human Resources Image Individual Internet Leadership Life Link Magnetic Resonance Imaging Marijuana Mental Health Mentors Methodology Mind Modeling Monitor Neurobiology Neurocognition Neurocognitive Outcome Participant Pattern Phenotype Policies Population Procedures Process Protocols documentation Psyche structure Psychopathology Publications Quality Control Recruitment Activity Reporting Research Research Design Research Personnel Research Project Grants Resolution Risk Sampling Scientist Site Standardization Stress Surveys Technology Technology Assessment Teleconferences Testing Time TimeLine Training Trauma Twin Multiple Birth Uncertainty United States National Institutes of Health Update Youth adolescent brain development adolescent substance use behavioral health cognitive neuroscience cohesion cohort computerized data sharing design early onset emerging adult experience flexibility handheld mobile device meetings misuse of prescription only drugs multidisciplinary neuroimaging novel outreach programs public health relevance success time use trend

项目摘要

DESCRIPTION (provided by applicant): The ABCD-USA Consortium proposes a study designed to permit our investigators and the scientific community to answer important questions about the effects of substance use (SU) on behavioral and brain development of adolescents. We have assembled a team of investigators with unparalleled research experience with youth, and specific expertise in adolescent SU, child and adolescent development, developmental psychopathology, longitudinal multi-site imaging, developmental neuroimaging and cognitive neuroscience, genetics and imaging genetics, bioassays, epidemiology, survey research, bioinformatics, and mobile assessment technologies. We propose a nationwide study of 10,000 9-10 year olds conducted at 21 sites organized into 11 hubs (29% of the US population lives within 50 miles of our geographically spread sites), that, uniquely, can provide a nationally representative sample and a large twin sample that together can help distinguish environmental, sociocultural, and genetic factors relevant to SU and brain development. We ensure cohesion and standardization with a recruitment strategy designed by a professional survey company (experience with Monitoring the Future); standardized environmental, neurocognitive and mental health assessments, MRI assessments with scanners using harmonized Human Connectome Project procedures, and computerized data collection with real-time quality control. Developmentally tailored assessments will have stable sensitivity and construct validity across childhood and adolescence, minimize participant burden, capture even subtle changes in SU, mental health, neurocognition, development, and environment, and employ novel bioassays and passive data collection from mobile devices. The retention plan builds on the experience of our investigators to ensure success. This application describes the ABCD-USA Coordinating Center (CC) which will: provide overall administrative and logistical support and scientific integration fr the consortium; establish and implement procedures for core protocols, participant recruitment and retention, and data quality control; provide initial and ongoing training of personnel for standardization; monitor cohort attributes, recruiting and retention practices, data quality, and consortium-wide consistency in real time, and monitor progress toward benchmarks and timelines. CC will ensure adherence to ethical standards and cultural sensitivity of research, and establish and implement policies for dispute resolution, internal and external data sharing, and publication. CC organizes and provides logistical support for meetings and teleconferences of the consortium, steering committee, scientific advisory board and workgroups as well as for educational, scientific, outreach, and dissemination events. By design, CC processes are flexible for problem resolution and incorporation of emerging scientific opportunities. We provide transparent study updates to the public via the web, and a well-managed and fully annotated repository of data for timely sharing. Importantly, we provide training and mentoring to developing scientists in the drug abuse area.

描述（由适用提供）：ABCD-USA财团提案一项研究旨在允许我们的研究人员和科学界回答有关物质使用（SU）对青少年行为和大脑发展的影响的重要问题。我们已经组建了一组研究人员，具有无与伦比的研究经验，并在青少年，儿童和青少年发展，发展心理病理学，纵向多站点成像，发展神经影像学和认知神经科学，遗传学和成像遗传学，生物学研究，流行病学研究，生物启示技术和移动技术和移动技术方面。 We propose a nationally representative study of 10,000 9-10 years olds conducted at 21 sites organized into 11 hubs (29% of the US population lives within 50 miles of our geographically spread sites), that, uniquely, can provide a nationally representative sample and a large twin sample that together can help distinguish environmental, sociocultural, and genetic factors relevant to SU and brain development.我们通过专业调查公司设计的招聘策略（监视未来的经验）确保凝聚力和标准化；标准化的环境，神经认知和心理健康评估，使用统一的人类连接项目程序进行扫描仪的MRI评估以及具有实时质量控制的计算机数据收集。开发量身定制的评估将在儿童和青少年之间具有稳定的敏感性和构建有效性，最少的参与燃烧，捕获SU，心理健康，神经认知，发展和环境的微妙变化，以及员工的新型生物测定以及从移动设备中收集的被动数据。保留计划基于我们的调查人员的经验，以确保成功。该应用程序描述了ABCD-USA协调中心（CC），该中心将：提供整体的行政和后勤支持以及财团的科学融合；建立和实施核心协议，参与者招聘和保留以及数据质量控制的程序；提供对人员进行标准化的初始和持续培训；监视队列属性，招聘和保留实践，数据质量和全联盟的一致性，并监视对基准和时间表的进度。 CC将确保遵守研究的道德标准和文化敏感性，并制定和实施争议解决，内部和外部数据共享以及出版物的政策。 CC组织并为财团，指导委员会，科学顾问委员会和工作组以及教育，科学，宣传和传播活动的会议和电信提供后勤支持。根据设计，CC流程可以灵活地解决新兴科学机会的问题和保险。我们通过网络向公众提供透明的研究更新，并提供良好的且完全注释的数据存储库，以及时共享。重要的是，我们为滥用药物滥用领域的发展科学家提供培训和心理。