ABCD-USA Consortium: Coordinating Center

ABCD-美国联盟：协调中心

基本信息

批准号：
10209550
负责人：
SANDRA A BROWN
金额：
$ 65万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-07-04 至 2023-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10209550
关键词：
10 year old Address Adherence Adolescence Adolescent Adolescent Development Alcohol or Other Drugs use Alcohols American Area Behavioral Benchmarking Bioinformatics Biologic Development Biological Assay Brain Child Child Development Child Health Childhood Communication Communities Cultural Sensitivity Data Data Analyses Data Collection Development Disputes Drug abuse Drug usage Emotional Ensure Environment Epidemiology Ethics Event Functional disorder Future Genetic Geography Goals Human Human Resources Image Internet Leadership Link Logistics Magnetic Resonance Imaging Marijuana Mental Health Mentors Methodology Mind Modeling Monitor Neurocognition Neurocognitive Participant Patient Recruitments Pattern Phenotype Policies Population Procedures Process Protocols documentation Psyche structure Psychopathology Publications Quality Control Reporting Research Research Design Research Personnel Research Project Grants Resolution Risk Sampling Scientist Site Standardization Stress Surveys Technology Technology Assessment Teleconferences Testing Time TimeLine Training Trauma Twin Multiple Birth Uncertainty United States National Institutes of Health Update Youth adolescent brain development adolescent substance use cognitive neuroscience cohesion cohort computerized connectome data quality data sharing data warehouse design early onset emerging adult experience flexibility handheld mobile device health assessment imaging genetics imaging study marijuana use meetings misuse of prescription only drugs multidisciplinary neuroimaging novel outreach participant retention programs real time monitoring recruit social culture success time use trend

项目摘要

PROJECT SUMMARY The ABCD-USA Consortium proposes a study designed to permit our investigators and the scientific community to answer important questions about the effects of substance use (SU) on behavioral and brain development of adolescents. We have assembled a team of investigators with unparalleled research experience with youth, and specific expertise in adolescent SU, child and adolescent development, developmental psychopathology, longitudinal multi-site imaging, developmental neuroimaging and cognitive neuroscience, genetics and imaging genetics, bioassays, epidemiology, survey research, bioinformatics, and mobile assessment technologies. We propose a nationwide study of 10,000 9-10 year olds conducted at 21 sites organized into 11 hubs (29% of the US population lives within 50 miles of our geographically spread sites), that, uniquely, can provide a nationally representative sample and a large twin sample that together can help distinguish environmental, sociocultural, and genetic factors relevant to SU and brain development. We ensure cohesion and standardization with a recruitment strategy designed by a professional survey company (experience with Monitoring the Future); standardized environmental, neurocognitive and mental health assessments, MRI assessments with scanners using harmonized Human Connectome Project procedures, and computerized data collection with real-time quality control. Developmentally tailored assessments will have stable sensitivity and construct validity across childhood and adolescence, minimize participant burden, capture even subtle changes in SU, mental health, neurocognition, development, and environment, and employ novel bioassays and passive data collection from mobile devices. The retention plan builds on the experience of our investigators to ensure success. This application describes the ABCD-USA Coordinating Center (CC) which will: provide overall administrative and logistical support and scientific integration for the consortium; establish and implement procedures for core protocols, participant recruitment and retention, and data quality control; provide initial and ongoing training of personnel for standardization; monitor cohort attributes, recruiting and retention practices, data quality, and consortium-wide consistency in real time, and monitor progress toward benchmarks and timelines. CC will ensure adherence to ethical standards and cultural sensitivity of research, and establish and implement policies for dispute resolution, internal and external data sharing, and publication. CC organizes and provides logistical support for meetings and teleconferences of the consortium, steering committee, scientific advisory board and workgroups as well as for educational, scientific, outreach, and dissemination events. By design, CC processes are flexible for problem resolution and incorporation of emerging scientific opportunities. We provide transparent study updates to the public via the web, and a well-managed and fully annotated repository of data for timely sharing. Importantly, we provide training and mentoring to developing scientists in the drug abuse area.

项目概要 ABCD-美国联盟提出了一项研究，旨在让我们的研究人员和科学界社区回答有关物质使用 (SU) 对行为和大脑影响的重要问题青少年的发展。我们组建了一支具有无与伦比研究能力的研究人员团队青少年方面的经验，以及青少年 SU、儿童和青少年发展方面的具体专业知识，发育精神病理学、纵向多部位成像、发育神经影像学和认知神经科学、遗传学和成像遗传学、生物测定、流行病学、调查研究、生物信息学和移动评估技术。我们提议在 21 岁时对 10,000 名 9-10 岁儿童进行一项全国性研究站点分为 11 个中心（29% 的美国人口居住在距我们地理分布 50 英里的范围内）站点），独特的是，可以提供具有全国代表性的样本和大型双胞胎样本，这些样本一起可以帮助区分与 SU 和大脑发育相关的环境、社会文化和遗传因素。我们通过专业调查公司设计的招聘策略确保凝聚力和标准化（监控未来的经验）；标准化环境、神经认知和心理健康评估，使用协调的人类连接组项目程序使用扫描仪进行 MRI 评估，以及具有实时质量控制的计算机化数据收集。适合发展的评估将有整个童年和青少年时期稳定的敏感性和构建有效性，最大限度地减少参与者的负担，捕捉 SU、心理健康、神经认知、发育和环境的细微变化，以及采用新颖的生物测定法和移动设备的被动数据收集。保留计划建立在我们的调查人员的经验可确保成功。本申请描述了 ABCD-美国协调组织中心（CC）将：为该中心提供全面的行政和后勤支持以及科学整合财团；建立并实施核心协议、参与者招募和保留的程序，以及数据质量控制；为标准化人员提供初始和持续培训；监测队列属性、招聘和保留实践、数据质量和联盟范围内的实时一致性，以及监控基准和时间表的进展。 CC 将确保遵守道德标准和文化研究的敏感性，建立和实施争议解决、内部和外部数据的政策分享、出版。 CC 为委员会的会议和电话会议组织并提供后勤支持联盟、指导委员会、科学顾问委员会和工作组以及教育、科学、外展和传播活动。从设计上来说，CC 流程对于解决问题非常灵活，并且纳入新兴科学机会。我们通过以下方式向公众提供透明的研究更新 web，以及一个管理良好且注释齐全的数据存储库，以便及时共享。重要的是，我们提供为药物滥用领域的发展中的科学家提供培训和指导。