Clinical Translational Core

临床转化核心

• 批准号: 10240000
• 负责人: ROBERT Thomas SCHULTZ
• 金额: $ 18.91万
• 依托单位: CHILDREN'S HOSP OF PHILADELPHIA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-15 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10240000
• 关键词: Acute; Address; Advertisements; Age; Animals; Area; Behavior; Bioinformatics; Biological Markers; Biometry; Clinic; Clinical; Clinical Trials; Clinical and Translational Science Awards; Clinical assessments; Code; Cohort Studies; Collaborations; Communities; Computational Linguistics; Computer Vision Systems; Computer software; Consultations; Contracts; Custom; Data; Data Analyses; Data Analytics; Data Element; Data Science Core; Data Set; Database Management Systems; Databases; Developmental Disabilities; Diagnostic; Education; Electronic Health Record; Eligibility Determination; Ensure; Exclusion Criteria; Facial Expression; Family; Gait; Genes; Genetic; Genomics; Goals; Hospitals; Household; Human; Individual; Institutional Review Boards; Intellectual and Developmental Disabilities Research Centers; Intellectual functioning disability; Language; Leadership; Legal; Libraries; Light; Link; Machine Learning; Measurement; Measures; Mediation; Mission; National Institute of Mental Health; Neuropsychology; Newsletter; Outcome Measure; Patient Recruitments; Patients; Phase; Phenotype; Pre-Clinical Model; Preparation; Primary Health Care; Process; Protocols documentation; Provider; Quality Control; Questionnaires; Reporting; Reproducibility of Results; Research; Research Personnel; Research Project Grants; Research Support; Research Training; Resources; Sampling; Schools; Science; Services; Site; Speech; Structure; Techniques; Technology; Text; Translating; Translational Research; Treatment outcome; Visualization software; base; brain behavior; clinical phenotype; cohort; computable phenotypes; dashboard; data archive; data harmonization; data integration; data management; data submission; data visualization; design; digital; disability; falls; genomic data; innovation; medical specialties; neural circuit; neuroimaging; novel; phenotypic data; programs; psychologic; recruit; relating to nervous system; research study; response; social media; tool; web site

(CORE B- CTC: CLINICAL TRANSLATIONAL CORE) PROJECT SUMMARY Description: The Clinical Translational Core (CTC) provides a comprehensive set of services designed to enhance the impact and rigor of clinical translational research on Intellectual and Developmental Disabilities (IDD). Select services are novel and unavailable outside of the CTC; other services increase research efficiency and enhance quality control over study activities common to all CT research. Freeing individual IDDRC users of the burden of common activities in turn allows users to better deploy resources for innovation and maximizing the impact of their translational science. CTC services fall into four areas: (1) Assistance with assembling suitably large study cohorts to support rigorous, well-powered research. Recruitment of large samples is necessary for studies of developmental disabilities which have diverse clinical manifestations that must be measured and controlled for in data analyses to garner reproducible results. (2) Creation of study specific interactive databases and visualization tools which allow labs to track their study progress, efficiently allocate resources and effort, and prepare study reports and data submissions (e.g., NIMH Data Archive). The CTC, in collaboration with the Genomics and Data Integration and Neuroimaging and Neurocircuitry cores, support integration of different data types. (3) Support all phases of IRB and IND protocol preparation, submission and response to stipulations; and provide concierge services for other freely available research supports already on campus, such as services offered by CHOP’s Clinical Trials office, and services provided by the Penn/CHOP Clinical and Translational Science Award (CTSA). (4) Expert clinical assessment support, including support with conventional psychological measurement; computable phenotypes from bioinformatic analyses of the electronic health records (EHR); and novel digital phenotyping using computer vision and computational linguistics to achieve granular measurement of speech, language and observable behaviors (e.g., nonverbal facial expressions and synchrony between individuals during interactions). These technologies and analytic capabilities are especially valued as they are not otherwise available on campus or commercially. The CTC will partner with the Preclinical Models Core on computer vision measurement of animal and human behaviors (e.g., gait), to derive features for mapping across species in order to more rapidly translate study findings and validate promising treatments. Relevance to IDDRC Mission: The CTC facilitates interdisciplinary translational research and training in IDDs (e.g., by working closely with the Leadership Education in Neurodevelopmental and Related Disabilities (LEND) program). The CTC provides centralized resources as well as novel cutting-edge techniques to support and advance IDD research linking genes, brain and behavior. The CTC is integral to advancing science that will impact the lives of those with an intellectual and/or developmental disability. Eligibility: Services are available to approved users of the CHOP/Penn IDDRC and for cross-site collaborations with others within the IDDRC network.

（核心 B-CTC：临床转化核心） 项目概要 描述：临床转化核心 (CTC) 提供一套全面的服务，旨在 增强智力和发育障碍临床转化研究的影响力和严谨性 (IDD)。某些服务是新颖的且在 CTC 之外无法使用，其他服务可提高研究效率； 加强对所有 CT 研究通用的研究活动的质量控制，使 IDDRC 个人用户免受干扰。 共同活动的负担反过来又使用户能够更好地部署资源进行创新和最大化 他们的转化科学服务的影响分为四个领域：(1) 协助适当组装。 大型研究队列来支持严格、有力的研究 招募大量样本是必要的。 对具有不同临床表现的发育障碍的研究必须进行测量和 (2) 创建研究特定的交互式数据库 和可视化工具，使实验室能够跟踪他们的研究进度，有效地分配资源和精力，以及 与 CTC 合作准备研究报告和数据提交（例如 NIMH 数据档案）。 基因组学和数据集成以及神经影像和神经电路核心，支持不同数据的集成 (3) 支持IRB和IND协议准备、提交和响应规定的所有阶段； 为校园内已有的其他免费研究支持提供礼宾服务，例如服务 由 CHOP 临床试验办公室提供，以及 Penn/CHOP 临床和转化中心提供的服务 科学奖 (CTSA) (4) 专家临床评估支持，包括常规支持。 电子健康的生物信息学分析的心理测量； 记录（EHR）；以及使用计算机视觉和计算语言学来实现的新颖的数字表型分析 对言语、语言和可观察行为（例如非语言面部表情和 这些技术和分析能力尤其重要。 因其在校园或商业上无法获得而受到重视，CTC 将与临床前研究合作。 模型核心用于动物和人类行为（例如步态）的计算机视觉测量，以导出特征 绘制跨物种图谱，以便更快地转化研究结果并验证有希望的治疗方法。 与 IDDRC 使命的相关性：CTC 促进 IDD 领域的跨学科转化研究和培训 （例如，通过与神经发育和相关残疾领导力教育 (LEND) 密切合作 CTC 提供集中资源以及新颖的尖端技术来支持和实施。 IDD 研究进展将基因、大脑和行为联系起来，CTC 是推动科学发展不可或缺的一部分。 影响智力和/或发育障碍人士的生活。 资格：服务可供 CHOP/Penn IDDRC 的批准用户以及跨站点协作使用 与 IDDRC 网络内的其他人合作。