Harmonized Diagnostic Assessment of Dementia (DAD) for Longitudinal Aging Surveys in India (LASI)

印度纵向老龄化调查 (LASI) 痴呆症统一诊断评估 (DAD)

• 批准号: 10267745
• 负责人: Jinkook Lee
• 金额: $ 236.61万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-15 至 2026-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10267745
• 关键词: Adopted; Aerosols; Age; Age-Years; Aging; Air Pollution; American; Android; Auditory system; Biological; Biological Assay; Biology; Biomass; Blood; Brain; British; Cardiovascular system; Caregiver Burden; Caribbean region; Caring; Cellular Phone; Clinical; Clinical assessments; Coal; Cognition; Cognitive; Collection; Communities; Comparative Study; Consensus; Country; Data; Data Set; Dementia; Deterioration; Diagnosis; Diagnostic; Discipline; Economic Burden; Elderly; European; Exhibits; Exposure to; Fundus photography; Generations; Geography; Geriatrics; Goals; Government; Guidelines; Health; Health and Retirement Study; Hearing Tests; Household; Impaired cognition; Impairment; Incidence; Income; India; Individual; Inflammatory; International; Intervention; Interview; Investigation; Journals; Long-Term Care; Longitudinal Studies; Measurement; Measures; Medical; Metabolic; Methodology; Modeling; Monitor; Nature; Optics; Paper; Periodicity; Peripheral; Policies; Population; Population Heterogeneity; Prevention; Protocols documentation; Publishing; Reporting; Research; Research Personnel; Respondent; Retina; Risk Factors; Role; Sampling; Sensory; Serum; Societies; Source; South African; Stress; Surveys; Technology; Testing; Time; Training; Transportation; Venous; Visual; Visual impairment; Work; aged; ambient air pollution; base; biodemography; biological adaptation to stress; care costs; care giving burden; cognitive ability; cognitive change; cognitive testing; cooking; cost; data harmonization; dementia risk; digital; ethnic diversity; fine particles; follow-up; hearing impairment; illiterate; improved; informal caregiver; informant; innovation; insight; interest; recruit; sensor; sensory system; social; sociodemographics; spatiotemporal; tau Proteins; tau-1; webinar

Project Summary The Harmonized Diagnostic Assessment of Dementia for the Longitudinal Aging Study in India (LASI-DAD) is the first and only nationally representative and publicly available dataset on late-life cognition and dementia in India. Our overarching goals are to develop a first rate, longitudinal study of late-life cognition and dementia in India and to provide rich, high-quality data to the larger research community to advance our understanding of risk factors of late-life cognitive decline and dementia. Further, we administer the Harmonized Cognitive Assessment Protocol (HCAP), a common set of cognitive test batteries used by an international network of researchers, enabling new and innovative comparative studies across both low- and high-income countries. In this application, we aim to prepare for and collect Wave 2 of LASI-DAD. We will conduct follow up interviews at Wave 2 with all Wave 1 respondents and also recruit newly age-eligible respondents. Using Wave 2 data, we aim to estimate the dementia incidence rate at the population level and to investigate its predictors. We also aim to study cognitive changes and their correlates over the 4-year time period and to estimate the economic and caregiving burden of dementia. LASI-DAD provides an unprecedented opportunity to study key modifiable and non-modifiable risk factors for dementia and late-life cognitive decline. Rich, harmonized data on cognitive tests and informant reports, as well as venous blood assays and geriatric clinical assessments, enable cross-country comparisons of the influence of sociodemographic and biological variables (e.g. cardiovascular, metabolic, and inflammatory factors) on late-life cognition and dementia. For Wave 2, we will further innovate by: (1) expanding our venous blood assays to include total and phosphorylated tau protein in serum; (2) improving the measurement of personal exposure to PM2.5 using mobile sensors and identifying the relative contributions of different air pollution emission sources; (3) improving the hearing test protocol using an Android-based audiometry test; (4) assessing ocular health, including the use of retinal fundus photography; and (5) assessing caregiving burden. Altogether, the findings of the proposed investigation will yield new insights on the risk factors for dementia incidence and cognitive decline, allowing a better understanding of potential targets for dementia prevention in India and other countries around the world. As with Wave 1, we will prepare public use data and a codebook in a timely manner and promote data usage through exhibits, training webinars, and a user help desk, actively building a user base of researchers from across multiple scientific disciplines.