PORTLAND AREA COMMUNICATION RESEARCH CORE CENTER

波特兰地区通信研究核心中心

基本信息

批准号：
8892136
负责人：
Peter Gordon Barr-Gillespie
金额：
$ 61.5万
依托单位：
OREGON HEALTH & SCIENCE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2003
资助国家：
美国
起止时间：
2003-04-04 至 2016-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8892136
关键词：
Address Animals Area Auditory Auditory Brainstem Responses Basic Science Biomedical Engineering Budgets Clinical Research Collaborations Communication Communication Research Computer Hardware Computer software Computers and Advanced Instrumentation Core Facility Custom Data Databases Development Devices Disease Doctor of Philosophy Electronics Electrons Electroporation Engineering Environment Equilibrium Faculty Funding Genes Genetic Genotype Goals Grant Head and Neck Surgery Health Sciences Hearing Image Injection of therapeutic agent Institutes Labyrinth Lead Life Light Measurement Mechanics Medical Faculty Medical center Microscopic Mission Mus National Institute on Deafness and Other Communication Disorders Neurosciences Olfactory Pathways Oregon Otolaryngology Pathologic Plasmids Postdoctoral Fellow Principal Investigator Process Productivity Qualifying Rehabilitation therapy Request for Proposals Research Research Infrastructure Research Personnel Research Project Grants Resources Rivers Science Secure Sensory Smell Perception Software Engineering Students Technical Expertise United States Department of Veterans Affairs Universities Virus Washington Work Writing analog base data acquisition design design and construction digital experience in utero instrumentation interest member novel strategies otoacoustic emission programs public health relevance ranpirnase skills sound success

项目摘要

DESCRIPTION (provided by applicant): The Portland Area Communication Research Core Center will support twelve principal investigators in its Research Base, each of whom has one or more qualifying R01 grants funded by the NIDCD and or another institute. Eight other investigators with similar research interests are also members of the Core Center. The twenty investigators are affiliated with a variety of institutes in the greater Portland area: the Oregon Hearing Research Center (OHRC) at the Oregon Health & Science University (OHSU); the Vollum Institute (OHSU); the Department of Otolaryngology; Head & Neck Surgery (OHSU); the Department of Biomedical Engineering (OHSU); the National Center for Rehabilitative Auditory Research (NCRAR) at the Portland Veterans Administration (VA) Medical Center; and the Washington State University (WSU) Vancouver, which is just across the Columbia River from Portland. The group has a strong focus on and a substantial record of accomplishments in the auditory and vestibular sciences, with additional investigators interested in the olfactory system. The goal of the Core Center is to centralize expertise on bioengineering, imaging, and mouse genetics in order to enhance presently funded research projects and to stimulate collaborations among participating investigators. In order to achieve these goals, continued support of three Research Core facilities is proposed. The Bioengineering Core (Alfred Nuttall and Stephen David, Co-Directors) provides computer hardware and software support, support for design and construction of analog and digital circuits, as well as expertise and instrumentation for measurement of hearing acuity in live animals. The Imaging Core (Dennis Trune and Peter Steyger, Co-Directors) centralizes light, confocal, and electron-microscopic imaging through the existing Oregon Hearing Research Center infrastructure. The Mouse Core (Peter Gillespie and John Brigande, Co-Directors) provides expertise on mouse husbandry and genotyping, as well as in utero virus injection and plasmid electroporation to deliver exogenous genes into the inner ear. Support for an Administrative Shell is also requested. Support of the Core Center will facilitate increased efficiency, broader collaborations, and novel approaches in NIDCD-funded research projects.

描述（由申请人提供）：波特兰地区通信研究核心中心将在其研究基础上支持十二位首席调查员，每个研究基础都有一个或多个合格的R01赠款，由NIDCD和或其他研究所资助。其他具有类似研究兴趣的研究人员也是核心中心的成员。二十名调查人员隶属于大波特兰地区的各种机构：俄勒冈州健康与科学大学（OHSU）的俄勒冈州听力研究中心（OHRC）； Vollum Institute（OHSU）；耳鼻喉科系；头部和颈部手术（OHSU）;生物医学工程部（OHSU）；波特兰退伍军人管理局（VA）医疗中心国家康复研究中心（NCRAR）；华盛顿州立大学（WSU）温哥华，就在波特兰的哥伦比亚河对面。该小组在听觉和前庭科学领域的成就方面非常重视，并具有对嗅觉系统感兴趣的其他研究人员。核心中心的目的是集中有关生物工程，成像和老鼠遗传学的专业知识，以增强目前资助的研究项目并刺激参与研究人员之间的合作。为了实现这些目标，提出了三个研究核心设施的持续支持。生物工程核心（Alfred Nuttall和Stephen David，联合导演）提供了计算机硬件和软件支持，对模拟和数字电路的设计和构建的支持，以及用于测量现场动物听力敏锐度的专业知识和仪器。成像核心（Dennis Trune和Peter Steyger，联合导演）通过现有的俄勒冈州听力研究中心基础设施集中光，共聚焦和电子微观成像。小鼠核心（Peter Gillespie和John Brigande，联合导演）提供了有关小鼠饲养和基因分型的专业知识，以及子宫病毒注射和质粒电穿孔，以将外源基因输送到内耳中。还请求支持管理外壳。对核心中心的支持将有助于提高效率，更广泛的合作以及NIDCD资助的研究项目的新方法。