Processing Visual and Multisensory Information

处理视觉和多感官信息

基本信息

批准号：
8796183
负责人：
BARRY E STEIN
金额：
$ 36.52万
依托单位：
WAKE FOREST UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-02-01 至 2017-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8796183
关键词：
Adult Affect American Animals Anterior Auditory Behavior Behavioral Binding Biological Brain Cataract Cochlear Implants Cognitive Conflict (Psychology)Contralateral Cues Darkness Disease Dyslexia Environment Etiology Event Excision Exposure to Family Feedback Functional disorder Grant Hemianopsia Housing Human Impairment Individual Ischemic Brain Injury Life Maintenance Mediating Midbrain structure Modality Modification Motor Nature Neurons Perception Performance Physiological Play Preparation Probability Process Psychophysics Rehabilitation therapy Rewards Role Sensory Shapes Stimulus Structure Symptoms Testing Time Trauma Variant Visual autism spectrum disorder base behavioral response cognitive control cognitive process design developmental disease environmental change experience innovation mature animal multisensory neglect neural circuit novel postnatal programs relating to nervous system research study response retina implantation statistics superior colliculus Corpora quadrigemina tumor visual process visual processing

项目摘要

Project Summary The brain uses experience with environmental events to construct a framework for integrating the information received from its different senses. The end result is enhanced sensitivity to those cross-modal stimulus configurations that are likely to be derived from the same event. This capacity for 'multisensory integration'optimizes the brain's sensitivity to events of biological significance, and its behavioral responses to those events. It is of obvious survival value. The neural and behavioral manifestations of this process have been studied most extensively in the midbrain superior colliculus (SC), a structure involved in detecting and orienting to external stimuli. However, it is not yet known whether or not once formed during early life, the fundamental spatial and temporal principles that govern multisensory integration are 'fixed'thereafter, or can continue to adapt to changing environmental conditions. Nor is it known whether higher- order cognitive processes can co-opt these midbrain processes so that arbitrary covariant cross-modal features can be accommodated. Based on preliminary observations, we propose that the adult brain retains its sensitivity to the statistics of cross-modal events and is subject to cognitive oversight. Thus, any changes in those cross-modal statistics, or their significance, result in changes in the governing principles of multisensory integration. The present proposal uses multiple approaches and preparations to test these hypotheses. Adult animals will be exposed to systematic alterations in cross-modal statistics and/or their 'significance'via their association with reward. Then, the resultant short-term and long-term neural and behavioral effects of these experiences will be examined. The experiments are also designed to examine where in the neural circuit underlying SC multisensory integration, these experiences are encoded.

项目概要大脑利用环境事件的经验来构建一个框架整合从不同感官接收到的信息。最终结果得到增强对那些可能源自的跨模式刺激配置的敏感性同一个事件。这种“多感官整合”的能力优化了大脑的对具有生物学意义的事件的敏感性及其对这些事件的行为反应事件。具有明显的生存价值。这种现象的神经和行为表现该过程在中脑上丘（SC）中得到了最广泛的研究，参与检测和定向外部刺激的结构。然而，目前还没有我们不知道基本的空间和此后，控制多感官整合的时间原则就被“固定”，或者可以不断适应不断变化的环境条件。也不知道是否更高秩序认知过程可以选择这些中脑过程，以便任意协变可以容纳跨模式特征。根据初步观察，我们提出成人大脑保留对跨模式事件统计的敏感性并受到认知监督。因此，这些跨模式统计数据的任何变化，或它们的重要性，导致多感官控制原理的变化一体化。本提案使用多种方法和准备来测试这些假设。成年动物将面临跨模式的系统性改变统计数据和/或它们通过与奖励的关联的“重要性”。然后，得到的结果是这些经历的短期和长期神经和行为影响将是检查了。这些实验还旨在检查神经回路中的位置在 SC 多感官整合的基础上，这些体验被编码。