Creating a computerized self-administered version of Comprehensive Behavioral Int

创建综合行为智能的计算机化自我管理版本

• 批准号: 8848891
• 负责人: Michael B Himle
• 金额: $ 42.05万
• 依托单位: PSYC TECH, LTD
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-01 至 2017-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8848891
• 关键词: Address; Adrenergic Agonists; Adverse effects; Adverse event; Age; Antipsychotic Agents; Area; Award; Behavior Therapy; Behavioral; Child; Chronic; Clinical; Clinical Trials; Comorbidity; Computers; Data; Development; Disease; Dose; Family; Feedback; Fees; Frequencies; Gilles de la Tourette syndrome; Habits; Health; Impairment; Individual; Internet; Intervention; Lead; Marketing; Measures; Medication Management; Modeling; Monitor; Motor Tics; Parents; Participant; Patients; Pattern; Pharmaceutical Preparations; Pharmacological Treatment; Pharmacotherapy; Phase; Pilot Projects; Process; Protocols documentation; Provider; Quality of life; Randomized Clinical Trials; Randomized Controlled Trials; Relaxation Therapy; Research; Resources; School-Age Population; Self-Administered; Severities; Site; Small Business Innovation Research Grant; Strategic Planning; Symptoms; Testing; Therapeutic; Tic disorder; Time; Training; Travel; Visit; Vocal Tics; Work; active method; base; commercialization; comparative efficacy; computerized; cost; cost effective; efficacy testing; follow-up; impression; improved; indexing; innovation; neuropsychiatry; preference; programs; prototype; psychosocial; response; satisfaction; secondary outcome; self help; social; usability

DESCRIPTION (provided by applicant): This Phase II SBIR proposes to expand upon our successful Phase I activities to finalize development and test the efficacy of an innovative computer-based treatment-delivery product for children with Chronic Tic Disorders (CTD; including Tourette Disorder) and their families. CTD represents a class of neuropsychiatric disorders, occurring in 0.6-3% of school-aged children that can lead to significant impairments in physical, social, academic, and interpersonal functioning and reduced quality of life. Currently, there is no cure for CTD, however in large-scale randomized controlled trials; a non-pharmacological treatment known as Comprehensive Behavioral Interventions for Tics (CBIT) was shown to reduce tics without the adverse side effects associated with pharmacotherapy. A therapist-guided, empirically validated CBIT protocol is available; however the vast majority of individuals who desire CBIT do not have access to therapists trained in the delivery of this intervention. Given the need for non-pharmacological treatment options for children with CTD, a desire for such treatments by potential end-users, and the absence of practitioners adequately trained in the treatment, there is a clear need for innovative modes of dissemination. Following our recently completed (and successful) Phase I project, the current proposal partners two of the primary developers of the CBIT intervention with PsycTech Ltd., to finalized development and test a highly accessible and relatively inexpensive computerized self-help version of CBIT. Results from our Phase I project demonstrated that a prototype version of TICHELPER received high ratings from both professionals and end-users (children with CTD and their parents) on indices of feasibility, acceptability, and usability. Results from the Phase I pilot study also sho that TICHELPER was effective for reducing core CTD symptoms. Phase I results strongly justify Phase II, during which we will fully develop and test the efficacy of Tic Helper. This Phase II proposal aims to (1) use an iterative feedback process with end-users to develop the remaining core components of the CBIT protocol (i.e., relaxation training, function-based intervention, and the fully developed habit reversal module to address core CTD symptoms) into a self-administered online format, and (2) to compare the efficacy of TICHELPER to an Internet-Based Resources (IBR) condition in a randomized controlled trial.

描述（由申请人提供）：本II阶段SBIR提议扩展我们成功的I期活动，以最终确定开发并测试基于计算机的创新治疗递送产品对患有慢性疾病的儿童（CTD；包括Tourette障碍）及其家人的功效。 CTD代表了一类神经精神疾病，发生在0.6-3％的学龄儿童中，这些儿童可能导致身体，社会，学术和人际功能和降低生活质量的障碍。目前，CTD无法治愈，但是在大规模的随机对照试验中；证明了一种被称为TICS（CBIT）的全面行为干预措施的非药物治疗可减少抽动，而没有与药物治疗相关的不良副作用。提供了由治疗师引导，经验验证的CBIT方案；但是，绝大多数渴望CBIT的人无法获得接受此干预措施的培训的治疗师。鉴于需要为患有CTD儿童的非药物治疗选择，潜在的最终用户对这种治疗的渴望以及在治疗中接受足够培训的从业者的缺乏，因此显然需要进行创新的传播方式。在我们最近完成（成功）的I期项目之后，当前的提案合作伙伴与Psyctech Ltd.的CBIT干预的两个主要开发人员一起完成了最终确定开发，并测试了CBIT的高度易于访问且相对便宜的计算机化自助版。我们I阶段项目的结果表明，Tichelper的原型版本在可行性，可接受性和可用性指标上获得了专业人士和最终用户（CTD及其父母儿童）的高评级。第一阶段试验研究的结果还表明，Tichelper可有效减少核心CTD症状。第一阶段的结果强烈证明了第二阶段的合理性，在此期间，我们将充分开发和测试TIC助手的功效。该第二阶段的建议旨在（1）使用最终用户的迭代反馈过程将CBIT协议的剩余核心组成部分（即放松培训，基于功能的干预措施以及全面开发的习惯逆转模块解决核心CTD症状）以自动化的在线格式，以及（2）进行互联网的依据，以互联网为基础iNCERTE Internet Internet Internet（2），以解决Internet的良好级别的Intern Internet（2）。