Developmental Research Program

发展研究计划

• 批准号: 8930237
• 负责人: ALEXANDER KEITH STEWART
• 金额: $ 11.88万
• 依托单位: MAYO CLINIC ARIZONA
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-01 至 2020-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8930237
• 关键词: Area; Basic Science; Clinic; Clinical; Clinical Investigator; Clinical Research; Clinical Trials; Collaborations; Development; Discipline; Fostering; Foundations; Funding; Future; Goals; Grant; Incidence; Laboratory Study; Mayo Clinic Cancer Center; Monitor; Multiple Myeloma; Outcome; Patients; Pilot Projects; Psychological Techniques; Quality of life; Recommendation; Research; Research Infrastructure; Research Personnel; Research Project Grants; Research Support; Scientist; Seeds; Testing; Translating; Translational Research; United States National Institutes of Health; base; improved; innovation; mortality; novel; programs; sound; translational study; tumor

ABSTRACT: The goal of the Developmental Research Program in the Mayo Clinic SPORE in Multiple Myeloma is to support innovative, scientifically sound projects that investigate any area pertaining to translational myeloma research. Funding from this program will stimulate developmental research that incorporates techniques and theoretical approaches that may not have been previously utilized in myeloma research. In so doing it provides a mechanism by which the SPORE can increase the number of scientists and clinical investigators who are committed to translational myeloma research. The Developmental Research Program will encourage the development of suitable projects, coordinate project review and selection, make funding recommendations to the Executive Committee, and monitor research progress. We have requested $130,000 annually ($80,000 per year from the SPORE funds augmented by $50,000 per year in matching funds from the Mayo Clinic Cancer Center) for the Developmental Research Program. We aim to provide research support to two to three projects per year for one year with a second year of support possible based on exceptional progress towards the stated aims of the project. The long term goal is to translate the findings generated by developmental projects into a reduction in the incidence and mortality rates of myeloma. Without the funding, infrastructure, and expertise of the SPORE projects and investigators, it will be unlikely that innovative developmental research projects of the kind we envision can be brought to fruition. Specifically, the primary goals of the Developmental Research Program are to: (1) encourage innovative translational studies that are promising and have the potential to improve outcome in myeloma and mature into independently funded projects; (2) foster extensive collaboration between basic science and clinical disciplines in translational research in myeloma in the context of the myeloma SPORE program; (3) encourage investigators to apply their research findings in other tumor types to translational research in myeloma and; (4)generate new hypotheses that can be tested and provide the foundation for future large-scale research projects or clinical trials in order to reduce myeloma incidence and mortality rates.

抽象的： 多发性骨髓瘤的梅奥诊所孢子中发展研究计划的目标是 支持创新的，科学的声音项目，调查与翻译有关的任何领域 骨髓瘤研究。该计划的资金将刺激整合的发展研究 以前可能未在骨髓瘤研究中使用的技术和理论方法。在 因此，这样做提供了一种机制，孢子可以增加科学家和临床的数量 致力于转化骨髓瘤研究的研究者。发展研究 计划将鼓励开发合适的项目，协调项目审查和选择， 向执行委员会提出资金建议，并监控研究进度。我们有 每年要求$ 130,000（每年$ 80,000的孢子资金每年增加50,000美元 从Mayo诊所癌症中心）进行发展研究计划的资金。我们的目标 每年为两到三个项目提供研究支持，并获得第二年的支持 可能基于向项目的既定目标取得的出色进步。长期目标是 将发展项目产生的发现转化为降低发病率和死亡率 骨髓瘤的发生率。没有孢子项目的资金，基础设施和专业知识 调查人员，我们所设想的创新性发展研究项目不太可能 实现。具体而言，发展研究计划的主要目标是：（1） 鼓励具有希望的创新转化研究，并有可能改善结果 骨髓瘤并成熟成独立资助的项目； （2）促进基本之间的广泛合作 在骨髓瘤孢子的背景下，骨髓瘤转化研究的科学和临床学科 程序; （3）鼓励研究人员将其研究结果应用于其他肿瘤类型 骨髓瘤的研究； （4）产生可以测试的新假设，并为 未来的大规模研究项目或临床试验，以降低骨髓瘤的发病率和死亡率 费率。