Administrative Core: Cellular and molecular mediators of fibrosis in the development of urinary tract dysfunction

管理核心：尿路功能障碍发展中纤维化的细胞和分子介质

基本信息

批准号：
10264803
负责人：
WILLIAM A RICKE
金额：
$ 46.89万
依托单位：
UNIVERSITY OF WISCONSIN-MADISON
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-09-24 至 2024-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10264803
关键词：
5 Alpha-Reductase Inhibitor Adrenergic alpha-Antagonists Affect Aging American Animal Model Area Benign Benign Prostatic Hypertrophy Biomedical Research Boston Businesses Cell model Collaborations Communication Communities Computer software Consensus Cost of Illness Development Discipline Disease Doctor of Philosophy Ensure Equipment Faculty Fibrosis Functional disorder Funding Funding Opportunities Future Goals Individual Instruction Lead Leadership Letters Life Link Lower urinary tract Mediator of activation protein Medical Mentored Clinical Scientist Development Program Methods Mission Molecular National Institute of Diabetes and Digestive and Kidney Diseases Pathway interactions Patients Pharmaceutical Preparations Population Preclinical Testing Production Productivity Prostate Protocols documentation Quality of life Reproducibility Research Research Personnel Research Training Resources SECTM1 gene Scientific Societies Scientist Series Services Site Visit Special Event Students Sum Therapeutic Tissue Model Training Training Programs Translating Universities Urinary tract Urology Vision Voice Wisconsin Work antifibrotic treatment cellular targeting clinically relevant cost data dissemination effectiveness research experience innovative technologies lower urinary tract symptoms meetings member new therapeutic target next generation organizational structure outreach program patient biomarkers patient stratification programs symposium urologic

项目摘要

PROJECT SUMMARY - ADMINISTRATIVE CORE The Administrative Core (Core A), has an overall mission to coordinate and successfully manage the UW- Madison O’Brien Research Center including UM-Boston and UT-Southwestern and lead benign urology research into the future. The overarching goal of the O’Brien Center for Benign Urology Research is to identify mechanisms that result in lower urinary tract dysfunction (LUTD) that result in benign prostatic hyperplasia (BPH) related lower urinary tract symptoms (LUTS). Criteria for successful completion are defined by the RFA 18-029 and include performing and disseminating outstanding benign urologic research, provide highly needed resources for the field, and provide outstanding educational enrichment while promoting the next generation of benign urology researchers. The Center targets new and exciting mechanisms of LUTD namely prostate fibrosis and translates it to clinically relevant therapeutics and biomarkers for patient stratification. BPH/LUTS can be life-threatening, affect quality of life, and is a costly disease, which NIDDK wants eradicate. Core A will achieve these goals by providing outstanding leadership, vision, and efficiency in the overarching administrative duties. The organization structure and leadership of Core A includes two outstanding investigators with recognized and complementary abilities in leading research groups and training programs. Dr. Ricke continues to serve as Core A director and will assume primary responsibility for day to day management and oversight of Core A. He will also be responsible for obtaining and managing the Opportunity Pool and maintain extensive interactions within the biomedical community. Dr. Vezina will serve as Associate Director for Core A and will direct the Educational Enrichment Program. Core A will interact with members of its external advisory board (EAB) and internal advisory board (IAB) on a semi-annual basis. All members or associated members of the center will be invited to partake in center functions including seminars, retreats, business meetings, and other special events. Drs. Ricke and Vezina meet with the NIDDK Executive Steering committee (ESC) and External Expert Panel (EEP) at NIDDK’s annual reverse site visit (see letter of reference Mark Nelson, PhD, ESC Chair). Their leadership and experience will allow us to promote interactions between our Center Projects, Core B, as well as other centers (U54, P20, K12) through: communication, collaboration, and coordination. Further interactions and data dissemination will occur in conjunction with the NIDDK’s O’Brien Center Interaction core, NIDDK program officials, American Urological Association Office of Research, scientific societies, and other venues. As directed by NIDDK, the benign urology research community has a viable focal point--The O’Brien Centers--in which to centralize ideas, research, resources, training, provide consensus, and offer a unified voice. The O’Brien Centers are more than the sum of parts, rather they provide leadership, synergize with researchers, and provide to the urology community above and beyond serving one’s own Center. Core A will lead this NIDDK shared vision.

项目摘要 - 行政核心行政核心（核心 A）的总体使命是协调和成功管理威斯康星大学- 麦迪逊·奥布莱恩研究中心（包括 UM-Boston 和 UT-Southwestern）领导泌尿学研究奥布莱恩良性泌尿学研究中心的总体目标是确定。导致下尿路功能障碍 (LUTD) 的机制，进而导致良性前列腺增生 (BPH) 相关下尿路症状 (LUTS) 的成功完成标准由 RFA 18-029 定义。包括进行和传播杰出的良性泌尿外科研究，提供急需的为该领域提供资源，并提供出色的教育丰富性，同时促进下一代该中心致力于研究 LUTD 的新机制，即前列腺纤维化。并将其转化为用于 BPH/LUTS 患者分层的临床相关治疗方法和生物标志物。危及生命、影响生活质量，并且是一种代价高昂的疾病，NIDDK 希望核心 A 能够根除这种疾病。这些目标是通过在总体行政职责中提供出色的领导力、远见和效率来实现的。 Core A 的组织结构和领导层包括两位杰出的研究人员，他们具有公认的和 Ricke 博士继续担任核心研究小组和培训项目的互补能力。董事，将承担核心 A 日常管理和监督的主要责任。他将还负责获取和管理机会池并在内部保持广泛的互动 Vezina 博士将担任核心 A 的副主任，并指导教育部门。强化计划。核心 A 将与其外部顾问委员会 (EAB) 和内部顾问成员进行互动。每半年一次的委员会（IAB）将邀请中心的所有成员或相关成员参加。中心活动包括研讨会、静修会、商务会议和其他特别活动。 Vezina 在 NIDDK 会见 NIDDK 执行指导委员会 (ESC) 和外部专家小组 (EEP) 年度反向现场访问（参见推荐信 Mark Nelson 博士、ESC 主席）。将使我们能够促进我们的中心项目、核心 B 以及其他中心（U54、P20、 K12）通过：沟通、协作和协调将进一步互动和数据传播。与 NIDDK 的奥布莱恩中心互动核心、NIDDK 项目官员、美国泌尿外科协会研究办公室、科学协会和其他场所根据 NIDDK 的指示。良性泌尿学研究界有一个可行的焦点——奥布莱恩中心——在其中集中思想，研究、资源、培训、提供共识并发出统一的声音奥布莱恩中心的意义远不止于此。各个部分的总和，而是它们提供领导作用，与研究人员协同作用，并为泌尿外科提供帮助核心 A 将领导 NIDDK 的共同愿景。