P-30 Core Grant for Vision Research

P-30 视觉研究核心补助金

基本信息

批准号：
8708860
负责人：
David H Brainard
金额：
$ 76.91万
依托单位：
UNIVERSITY OF PENNSYLVANIA
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
起止时间：
1997-09-01 至 2015-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8708860
关键词：
Affect Animal Model Basic Science Biological Preservation Biometry Blindness Cancer Center Support Grant Cellular biology Clinical Research Collaborations Communities Computer Simulation Conduct Clinical Trials Confocal Microscopy Consult Data Analyses Development Disease Electrodes Equipment Experimental Designs Eye Fostering Funding Goals Grant Human Human Resources Image Image Analysis Imaging technology In Vitro Individual Life Methods Microscope Mission Molecular Biology Molecular Genetics Optics Pennsylvania Physiological Physiology Primates Printing Psychophysics Public Health Qualifying Recruitment Activity Research Research Personnel Research Project Grants Research Support Retina Retinal Retinal Degeneration Running Scientist Services Solutions Source Technical Expertise Tissues Universities Vision Vision research Visual Cortex Visual Pathways Visual Psychophysics Visual impairment Work awake cognitive neuroscience cost design and construction gene therapy imaging modality in vivo insight instrument instrumentation meetings posters programs ranpirnase skills two-photon visual performance

项目摘要

DESCRIPTION (provided by applicant): The broad goal of this proposal is to provide core support services for 26 Participating Investigators and 24 Associate Investigators to: (1) enhance the quality and quantity of their research; (2) facilitate collaborations between investigators with different backgrounds and skills; and (3) recruit new investigators to vision research, help young vision investigators establish their labs, and allow established investigators to explore new directions. Participating Investigators hold P30-qualifying individual research grants from NEI, and Associate Investigators hold individual grants from other sources or are applying for funding. Collectively the investigators represent a broad range of vision research, and include experts on animal models of retinal degeneration, retinal circuitry, gene therapy, cell and molecular biology, molecular genetics, eye, central visual pathways and cortical physiology, visual performance and cortical function in awake-behaving primates, cognitive neuroscience of vision, computational modeling, and visual psychophysics. The core grant will support 5 modules: Biostatistics provides expert assistance in experimental design and data analysis particularly for clinical studies; Image Analysis provides expert support for the development and implementation of image analysis solutions; Instrumentation provides for design and construction of optical and electrophysiological instruments that are unavailable from commercial sources; Noninvasive Assessment of Visual Function provides equipment and technical support for assessing visual function in animal models and humans. Principle methods include ERG, pupillometry, and psychophysics; Shared Imaging Equipment provides vision investigators access to shared equipment for a variety of imaging modalities, including conventional and two-photon confocal microscopy, multi-electrode array recording from in vitro tissue, and confocal SLO combined with spectral OCT imaging of in vivo retina.

描述（由申请人提供）：该提案的广泛目标是为26名参与调查人员和24名副研究人员提供核心支持服务，以提高其研究的质量和数量；（2）促进具有不同背景和技能的调查人员之间的合作；（3）招募新的研究人员来视力研究，帮助年轻视觉研究人员建立实验室，并允许既定的研究人员探索新的方向。参与的研究人员持有NEI的P30质量研究赠款，而副研究人员则持有其他来源的个人赠款或正在申请资金。研究人员总体代表了广泛的视力研究，包括视网膜变性，视网膜回路，基因治疗，细胞和分子生物学，分子遗传学，眼睛，中央视觉途径和皮质生理，视觉性能，视觉性能和皮质功能的专家，在清醒的灵长类动物中，对觉得神经科学，计算性模型和视觉模型学和视觉模型，以及视觉性神经科学，以及视觉模型，以及视觉模型。核心赠款将支持5个模块：生物统计学为实验设计和数据分析提供了专家帮助，尤其是在临床研究中；图像分析为图像分析解决方案的开发和实施提供了专家支持；仪器提供了从商业来源无法获得的光学和电生理仪器的设计和构建；视觉功能的无创评估为评估动物模型和人类的视觉功能提供了设备和技术支持。原理方法包括ERG，瞳孔测定法和心理物理学；共享成像设备为视觉研究人员提供了各种成像方式共享设备的访问，包括传统和两光子共聚焦显微镜，来自体外组织的多电极阵列记录以及共聚焦SLO与体内视网膜的光谱OCT成像相结合。