P30 Core Grant for Vision Research

P30 视觉研究核心资助

• 批准号: 10020564
• 负责人: David H Brainard
• 金额: $ 64.79万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-01 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10020564
• 关键词: Affect; Animal Model; Basic Science; Bioinformatics; Biometry; Blindness; Cellular biology; Clinical Research; Collaborations; Computer Models; Confocal Microscopy; Core Grant; Custom; Data; Data Analyses; Disease; Electrophysiology (science); Equipment; Experimental Designs; Eye; Goals; Grant; Image; In Vitro; Maintenance; Molecular Biology; Molecular Genetics; National Eye Institute; Pennsylvania; Physiology; Primates; Public Health; Qualifying; Reproducibility; Research; Research Personnel; Research Project Grants; Resources; Retina; Retinal Degeneration; Savings; Scientist; Services; Software Tools; Source; Stimulus; Tissues; Universities; Vision; Vision research; Visual Cortex; Visual Pathways; Visual Psychophysics; Visual impairment; awake; cognitive neuroscience; data acquisition; data curation; design and construction; gene therapy; imaging modality; insight; instrument; instrumentation; multi-electrode arrays; novel; programs; ranpirnase; recruit; repaired; skills; two-photon; visual performance

Overall - Project Summary The broad goal of this proposal is to provide core support services for 16 Participating Investigators and over 40 Associate Investigators to: (1) enhance the quality and quantity of their research; (2) facilitate collaborations between investigators with different backgrounds and skills; and (3) recruit new investigators to vision research, help young vision investigators establish their labs, and allow established investigators to explore new directions. The Participating Investigators hold 18 qualifying R01 research grants from the National Eye Institute. The Associate Investigators study vision but do not currently hold a qualifying R01 grant from the NEI. Collectively, the investigators represent a broad range of vision research, and include experts on animal models of retinal degeneration, retinal circuitry, gene therapy, cell and molecular biology, molecular genetics, eye, central visual pathways and cortical physiology, visual performance and cortical function in awake- behaving primates, cognitive neuroscience of vision, computational modeling, and visual psychophysics. The core grant will support 4 resource/service modules: Biostatistics provides expert assistance in experimental design and data analysis, particularly for clinical studies, as well as bioinformatics support; Imaging and Electrophysiology provides vision investigators access to shared equipment and technical support for a variety of imaging modalities and electrophysiological recording, including conventional and two-photon confocal microscopy, multi-electrode array recording from in vitro tissue, and spectral OCT imaging; Instrumentation provides for design and construction of custom stimulus delivery, data acquisition, and electrophysiological instruments that are unavailable from commercial sources, as well as maintenance and repair of such instruments; Scientific Transparency develops novel software tools for pre-processing, analysis, and presentation of imaging data, and supports data curation and analysis reproducibility.

总体 - 项目摘要 该提案的广泛目标是为16名参与调查人员及以上的核心支持服务 40个副研究人员：（1）提高其研究的质量和数量； （2）促进合作 在背景和技能不同的调查人员之间； （3）招募新调查人员 研究，帮助年轻远见研究人员建立他们的实验室，并允许成熟的研究人员探索 新方向。参与的调查人员从国家眼中持有18个合格的R01研究补助金 研究所。副研究人员研究愿景，但目前尚未获得NEI的合格R01赠款。 总的来说，调查人员代表了广泛的视力研究，并包括动物专家 视网膜变性，视网膜电路，基因治疗，细胞和分子生物学，分子遗传学模型， 眼睛，中央视觉途径和皮质生理学，视觉性能和皮质功能 行为灵长类动物，视力的认知神经科学，计算建模和视觉心理物理学。这 核心赠款将支持4个资源/服务模块：生物统计学为实验提供专家帮助 设计和数据分析，特别是用于临床研究以及生物信息学支持；成像和 电生理学使视力调查人员可以访问共享设备和技术支持 各种成像方式和电生理记录，包括常规和两光子 共聚焦显微镜，从体外组织记录的多电极阵列和光谱OCT成像； 仪器提供定制刺激交付，数据获取以及的设计和构建 来自商业来源以及维护和维护和维护的电生理仪器 维修此类工具；科学透明度开发了用于预处理的新型软件工具， 分析和成像数据的介绍，并支持数据策展和分析可重复性。