RGR-based motion tracking for real-time adaptive MR imaging and spectroscopy

基于 RGR 的运动跟踪，用于实时自适应 MR 成像和光谱学

• 批准号: 8762194
• 负责人: THOMAS M ERNST
• 金额: $ 78.13万
• 依托单位: UNIVERSITY OF HAWAII AT MANOA
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-01 至 2019-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8762194
• 关键词: Angiography; Anxiety; Attenuated; Biomedical Engineering; Brain; Chemistry; Child; Clinical; Collaborations; Data; Detection; Development; Diagnosis; Drug usage; Drug user; Economics; Environment; Evaluation; FDA approved; Funding; Generations; Government; Hawaii; Head; Head Movements; Health; Human; Image; Individual; Infant; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Methods; Morphologic artifacts; Motion; Movement; Movement Disorders; Obstruction; Optics; Patients; Persons; Phase; Physiologic pulse; Physiology; Positioning Attribute; Predisposition; Process; RF coil; Relative (related person); Reliance; Research; Research Personnel; Residual state; Resolution; Rotation; Sampling; Scanning; Severities; Signal Transduction; Site; Skin; Slice; Spectrum Analysis; Speed; Strabismus; Structure; System; Techniques; Technology; Time; Training; Translations; Update; Validation; Visual; Work; base; clinical application; clinical efficacy; clinically relevant; commercialization; experience; improved; in vivo; innovation; meetings; millimeter; motion sensitivity; named group; novel; prevent; prospective; prototype; reconstruction; volunteer

DESCRIPTION (provided by applicant): This is a renewal application for 1R01 DA21146-01, a Bioengineering Research Partnership (BRP) to develop real-time prospective motion correction (PMC) for MRI. Magnetic resonance imaging (MRI) is a powerful technique for assessing the structure, function, and physiology of the human brain in vivo. MRI affords high spatial and temporal resolution, is non-invasive and repeatable, and may be performed in children. However, motion continues to be a substantial problem in many MR studies, especially those performed in children, infants, or subjects who are agitated or confused due to anxiety, drug use or sickness, resulting in data with motion artifacts that may prevent accurate diagnoses or assessments. Prospective motion correction can dramatically attenuate motion artifacts by dynamically tracking the motion of the head/brain during a scan, and continuously correcting acquisitions such that they are locked relative to the moving brain. In the initial project period, we made substantial progress in developing optical-based motion tracking and correction for MRI. While the initial prototype system performs well for relatively small and slow movements, the system may fail to sufficiently attenuate motion artifacts during clinically relevant motions (larger amplitudes and higher speed). The proposed competitive renewal will focus on resolving these issues, with the following specific Aims. (1) Improve robustness of motion correction with optical tracking. (2) Develop techniques for motion correction at higher velocities (up to 100mm/s and °/s), and implement these methods for a set of clinically relevant sequences. (3) Develop reconstruction techniques for data acquired during head motion. (4) Demonstrate clinical efficacy and utility of the motion correction methods developed. The work will be performed by an experienced team of investigators with a track record of collaboration, using modern 3T and 7T scanners. Implementing these innovations will increase the availability of adaptive motion correction technologies for the clinical arena, and promise improved and more robust MR scans in children and patients who have difficulty holding still, both in research and clinical settings.

描述（由应用程序提供）：这是1R01 DA21146-01的续订申请，这是一种生物工程研究合作伙伴（BRP），用于开发MRI实时前瞻性运动校正（PMC）。磁共振成像（MRI）是评估体内人脑的结构，功能和生理学的强大技术。 MRI提供高空间和临时分辨率，无创和可重复，可以在儿童中进行。但是，在许多MR研究中，运动仍然是一个重大的问题，尤其是那些因焦虑，吸毒或疾病而激动或困惑的儿童，婴儿或受试者进行的，导致具有运动伪像的数据，这些数据可能会阻止准确的诊断或评估。前瞻性运动校正可以通过在扫描过程中动态跟踪头部/大脑的运动并连续纠正采集，从而使它们相对于移动的大脑锁定，从而大大减弱了运动伪像。在最初的项目期间，我们在开发基于光学的运动跟踪和MRI校正方面取得了重大进展。虽然初始原型系统对于相对较小且缓慢的运动表现良好，但该系统可能无法充分衰减临床相关运动（较大的放大器和更高速度）的运动伪像。拟议的竞争更新将集中在解决这些问题上，并采用以下特定目标。 （1）通过光学跟踪提高运动校正的鲁棒性。 （2）开发以较高速度（高达100mm/s和°/s）的运动校正技术，并为一组临床相关序列实施这些方法。 （3）开发用于在头部运动过程中获取的数据的重建技术。 （4）证明了开发的运动校正方法的临床效率和效用。这项工作将由经验丰富的调查员团队使用现代3T和7T扫描仪进行协作记录。实施这些创新将提高临床领域的自适应运动校正技术的可用性，并在研究和临床环境中的儿童和患者中有望改善和更强大的MR扫描。