Ultra-fast whole-heart CT using z-motion of the X-ray source

使用 X 射线源 z 轴运动的超快速全心脏 CT

• 批准号: 7656593
• 负责人: Frederic Noo
• 金额: $ 32.18万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-01 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7656593
• 关键词: Algorithms; Arrhythmia; Back; Beds; Budgets; Cardiac; Collimator; Computer software; Computers; Data; Data Collection; Detection; Development; Dose; Evaluation; Goals; Heart; Human; Image; Knowledge; Letters; Measurement; Morphologic artifacts; Motion; Noise; Patients; Performance; Radiation; Research; Research Proposals; Resolution; Retinal Cone; Risk; Roentgen Rays; Rotation; Scanning; Scientist; Simulate; Somatotype; Source; Speed; Spottings; Stenosis; Translating; Translations; Validation; Vendor; X-Ray Computed Tomography; base; calcification; comparative; cost; data acquisition; detector; heart imaging; interest; meetings; reconstruction; simulation; theories; tool

DESCRIPTION (provided by applicant): X-ray computed tomography (CT) has become a prominent tool for cardiac imaging since the introduction of multislice CT in 1998. This prominence has come progressively with the increase in the number of detector rows and in the scanner rotation speed. However, the accuracy of cardiac CT imaging is currently strongly dependent on the patient (patients with heartbeat arrythmia, who are more at risk, are more difficult to image), and this accuracy furthermore comes at the cost of a high dose. The long-term goal of this research is to enable highly accurate CT imaging of the whole heart independently of the patient condition and with a dose comparable to typical CT scans. We hypothesize this goal will be reached using a new scanning concept, called complete single-beat whole-heart (CSWH) scanning, where tomographically-complete data covering the full heart is obtained within one heartbeat. For this first research on cardiac imaging with CSWH scans, we will focus on the following aims: (1) development and implementation of reconstruction algorithms for accurate imaging from cone-beam data on relevant CSWH scans, (2) comparative evaluation of CSWH scans in terms of data requirement and dose imparted using various collimation strategies, (3) comparative evaluation of CSWH scans in terms of imaging performance using computer simulated data and real data of anthropomorphic phantoms and using human ROC observer studies.

描述（由申请人提供）：自 1998 年引入多层 CT 以来，X 射线计算机断层扫描 (CT) 已成为心脏成像的重要工具。随着探测器行数和扫描仪数量的增加，这种重要性逐渐凸显旋转速度。然而，目前心脏CT成像的准确性很大程度上取决于患者（心律失常的患者风险更大，更难以成像），而且这种准确性是以高剂量为代价的。这项研究的长期目标是实现整个心脏的高精度 CT 成像，不受患者病情的影响，且剂量与典型 CT 扫描相当。我们假设使用一种新的扫描概念来实现这一目标，称为完整单搏全心脏（CSWH）扫描，其中在一次心跳内获得覆盖整个心脏的断层扫描完整数据。对于利用 CSWH 扫描进行心脏成像的首次研究，我们将重点关注以下目标：(1) 开发和实施重建算法，以便根据相关 CSWH 扫描的锥束数据进行精确成像，(2) 对 CSWH 扫描的比较评估就数据要求和使用各种准直策略给予的剂量而言，（3）使用计算机模拟数据和拟人模型的真实数据以及使用人类ROC观察者研究在成像性能方面对CSWH扫描进行比较评估。