Epidemiology and Natural History of Cancer-Associated Viruses

癌症相关病毒的流行病学和自然史

• 批准号: 10263752
• 负责人: SAM M MBULAITEYE
• 金额: $ 211.37万
• 依托单位: DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10263752
• 关键词: Acquired Immunodeficiency Syndrome; Affect; Biological; Biological Markers; Breast; Burkitt Lymphoma; Cancer Etiology; Case-Control Studies; Categories; Clinical; Cohort Studies; Collaborations; Comparative Study; Confidence Intervals; Data; Detection; Development; Disease; Epidemiology; Etiology; Extramural Activities; Falciparum Malaria; Fostering; General Population; Genetic Predisposition to Disease; Genetic Variation; Ghana; Goals; HIV; Head and Neck Cancer; Helicobacter pylori; Hepatitis B; Hepatitis C virus; Hodgkin Disease; Human; Human Herpesvirus 4; Human Herpesvirus 8; Human Papillomavirus; Immune response; Immunologics; Incidence; Individual; Infection; Infectious Agent; Kaposi Sarcoma; Laboratories; Link; Liver; Malaria; Malignant Neoplasms; Malignant neoplasm of cervix uteri; Malignant neoplasm of liver; Malignant neoplasm of lung; Malignant neoplasm of penis; Malignant neoplasm of testis; Measures; Methods; Modeling; Natural History; Non-Hodgkin' s Lymphoma; Oncornaviruses; Organ Transplant Research; Persons; Population; Privatization; Role; SEER Program; Saliva; Satellite Viruses; Specimen; Stomach; Transplant Recipients; Tumor Tissue; United States; Virus; cancer risk; cancer transplantation; comparative; data registry; infection risk; malignant breast neoplasm; malignant stomach neoplasm; metropolitan; multidisciplinary; neoplasm registry; pathogen; peripheral blood; population based; prospective; viral transmission

This project consists of several overlapping comprehensive, multidisciplinary population-based cohort and/or case-control studies to quantify the association between cancer-causing viruses (oncoviruses) with linked cancers. The projects include the HIV-AIDS Cancer Match (HACM) Study that links some 780,000 people with HIV-AIDS in 14 U.S. states and metropolitan regions with cancer registry data to examine cancer risk among HIV-infected individuals and the Transplant Cancer Match (TCM) Study that links some 175,000-transplant recipients to cancer registry data in 13 cancer for comparative studies. In addition, focused projects on BL include the Ghana BL Study and the EMBLEM Study with broad goals to study the role of infections, including HIV, immune responses to EBV and Plasmodium falciparum malaria and genetic susceptibility in the etiology to BL. The studies focus on the role of the role of immunological alteration, infection and risk for cancer, including BL, NHL, Hodgkin lymphoma, Kaposi sarcoma, lung cancer, cervical cancer, head and neck cancer, testicular cancer, breast cancer, penile cancer, and gastric cancer. Biological specimens (peripheral blood, saliva, tumor tissues), when available, are used to measure load of infectious agents, including HIV, EBV, and KSHV, also called HHV8, Pf malaria and genetic variation in the pathogens a or the host to characterize association of biomarkers with cancer. Collaborations with private and academic laboratories were established to foster development of detection methods for known or possible cancer-associated viruses. Study of the US HACM provides continuing evidence of strong and durable impact of HIV on cancer risk in HIV infected persons. Using cancer incidence rates for the United States HIV-infected and general populations and applying Poisson models to linked HIV and cancer registry data and from Surveillance, Epidemiology, and End Results program data, an estimated 7760 (95% confidence interval [CI] = 7330 t

该项目由多项重叠的、综合的、多学科的基于人群的队列和/或病例对照研究组成，以量化致癌病毒（致癌病毒）与相关癌症之间的关联。这些项目包括艾滋病毒-艾滋病癌症匹配 (HACM) 研究，该研究将美国 14 个州和大都市地区约 780,000 名艾滋病毒感染者与癌症登记数据联系起来，以检查艾滋病毒感染者的癌症风险，以及移植癌症匹配 (TCM)研究将约 175,000 名移植受者与 13 种癌症的癌症登记数据联系起来进行比较研究。此外，关于 BL 的重点项目包括加纳 BL 研究和 EMBLEM 研究，其广泛目标是研究感染的作用，包括 HIV、对 EBV 和恶性疟原虫疟疾的免疫反应以及 BL 病因学中的遗传易感性。研究重点是免疫改变、感染和癌症风险的作用，包括 BL、NHL、霍奇金淋巴瘤、卡波西肉瘤、肺癌、宫颈癌、头颈癌、睾丸癌、乳腺癌、阴茎癌、和胃癌。生物样本（外周血、唾液、肿瘤组织）（如果有）用于测量传染源的负荷，包括 HIV、EBV 和 KSHV（也称为 HHV8）、Pf 疟疾以及病原体或宿主的遗传变异以表征生物标志物与癌症的关联。与私人和学术实验室建立了合作，以促进已知或可能与癌症相关的病毒检测方法的开发。美国 HACM 的研究提供了持续的证据，证明艾滋病毒对艾滋病毒感染者的癌症风险有强大而持久的影响。使用美国 HIV 感染者和普通人群的癌症发病率，并应用泊松模型关联 HIV 和癌症登记数据以及监测、流行病学和最终结果计划数据，估计为 7760（95% 置信区间 [CI] = 7330） t