Real-time 3D Imaging Guided ART

实时 3D 成像引导 ART

基本信息

批准号：
8902326
负责人：
Steven Yi
金额：
$ 32.58万
依托单位：
XYKEN, LLC
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-06-01 至 2017-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8902326
关键词：
Address Algorithms Anatomy Breast Breast Cancer Patient Breast Cancer Treatment Cancer Etiology Cessation of life Chest Clinic Clinical Data Diagnosis Dose Ensure Foundations Funding Opportunities Image Incidence Intensity-Modulated Radiotherapy Ionizing radiation Life Life Style Location Malignant Neoplasms Malignant neoplasm of lung Marketing Methodology Methods Modality Modeling Modification Motion Nature Patients Phase Positioning Attribute Procedures Process Radiation Radiation Oncology Radiation therapy Research Shoulder Skin Cancer Small Business Innovation Research Grant Smoker Solutions Structure Surface System Techniques Technology Three-Dimensional Imaging Time Translating Uncertainty United States United States National Institutes of Health Universities Update Woman X-Ray Computed Tomography aging population base cancer therapy checkup examination cost design digital flexibility image guided image guided radiation therapy improved irradiation malignant breast neoplasm medical schools minimally invasive next generation non-invasive imaging programs prototype public health relevance research study response sensor simulation three-dimensional modeling treatment duration treatment planning virtual

项目摘要

DESCRIPTION (provided by applicant): The United States have the highest annual incidence rates of breast cancer in the word. It is the second-most common cancer (after skin cancer) and the second-most common cause of cancer death (after lung cancer). . It is estimated that, in 2014, there will be an estimated 1,665,540 new cancer cases diagnosed and 585,720 cancer deaths in the US. Worldwide more than one million new cases of breast cancer are found every year. Apparently, an effective or accurate, minimally invasive, and low-cost solution for breast cancer treatment will have enormous clinic impact and significance on saving women's lives. To address the problems and technical challenges facing breast radiation therapy (RT), together with its collaborator, we proposes a radically different methodology called 4D SGRT technology to dynamically compute on-treatment breast anatomy structure and adaptively re-plan the radiation therapy. The proposed technology uses a non-invasive and adaptive image guidance based methodology. It eliminates uncertainties due to setup, mobility, and deformation for optimized delivery. It is also expected to shortened breast RT session with improved accuracy, and reduces minimum treatment setup time. Successful completion of the project will provide foundation for the next generation breast RT, and make it possible for millions of breast cancer patients to benefit from the most recent technological advances in a timely fashion. The radiation therapy market is growing rapidly with annual cancer rates worldwide projected to increase by fifty percent by 2020, mainly due to aging population, increasing number of smokers and unhealthy life styles. The Fredonia Group estimated that U.S. has $16.8 billion US market for cancer therapies, and it is growing ten percent annually. With over 2,000 radiation treatment machines in the US and many more in the world, the market for a clinically acceptable 3D camera enabled adaptive therapy system is significant.

描述（由申请人提供）：美国的乳腺癌年发病率全球最高。它是第二大常见癌症（仅次于皮肤癌），也是第二大常见癌症死亡原因（仅次于肺癌）。据估计，2014 年，美国将新诊断出 1,665,540 例癌症病例，并有 585,720 例癌症死亡病例，全球新发乳腺癌病例将超过 100 万例。显然，一种有效、准确、微创、低成本的乳腺癌治疗方案将对挽救女性生命产生巨大的临床影响和意义。我们与其合作者一起提出了一种完全不同的方法，称为 4D SGRT 技术，用于动态计算治疗中的乳房解剖结构并自适应地重新规划放射治疗。该技术使用基于非侵入性和自适应图像引导的方法。由于不确定性该项目的成功完成将为下一代乳房 RT 奠定基础，并有望缩短乳房 RT 疗程并提高准确性。数以百万计的乳腺癌患者能够及时受益于最新的技术进步放射治疗市场正在迅速增长，预计到 2020 年，全球癌症发病率将增加 50%，这主要是由于人口老龄化、吸烟者数量的增加和癌症患者数量的增加。不健康的生活方式。据估计，美国的癌症治疗市场价值为 168 亿美元，并且每年增长 10%，美国拥有 2,000 多台放射治疗机，全球拥有更多，临床上可接受的 3D 摄像头自适应治疗系统的市场非常巨大。。