Augmenting Endoscopic Instruments with Real-time 3D Imaging

通过实时 3D 成像增强内窥镜仪器

• 批准号: 9339459
• 负责人: Steven Yi
• 金额: $ 34.57万
• 依托单位: XYKEN, LLC
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-03-01 至 2019-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9339459
• 关键词: Address; Affect; Aging; Anatomy; Appearance; Appendicitis; Area; Biopsy; Bronchoscopy; Chronically Ill; Clinic; Clinical; Colon; Colonoscopes; Colonoscopy; Color; Computer software; Cystoscopy; Data; Depth Perception; Devices; Diagnosis; Diagnostic; Digestive System Disorders; Digit structure; Dimensions; Disease; Distal; Documentation; Dose; Elderly; Electronics; Endoscopes; Endoscopy; Equipment; Esophagus; Funding Opportunities; Gases; Gastrointestinal Diseases; Gastrointestinal tract structure; Growth; Hemorrhage; Image; Image-Guided Surgery; Imagery; Impairment; Industry; Inflammatory Bowel Diseases; Laparoscopy; Location; Maintenance; Measurement; Medical; Methods; Modeling; Office Visits; Operative Surgical Procedures; Optics; Patients; Phase; Polyps; Population; Positioning Attribute; Procedures; Process; Publishing; Radiation; Radiation therapy; Recovery; Rectum; Reporting; Research; Research Personnel; Risk; Small Business Innovation Research Grant; Small Intestines; Stomach; Stream; Surface; Surgeon; System; Tablets; Techniques; Technology; Testing; Texture; Therapeutic; Therapeutic Intervention; Three-Dimensional Image; Three-Dimensional Imaging; Time; Tissues; Training; United States; United States National Institutes of Health; Virtual Endoscopy; Visual; Water; aging population; base; capsule; clinical Diagnosis; commercialization; cost; data exchange; design; digital; disease diagnosis; disorder prevention; economic impact; gastrointestinal; imaging system; in vivo; innovation; instrument; lens; miniaturize; minimally invasive; novel; operation; optical imaging; population based; prototype; response; retinal rods; sensor; simulation; software systems; therapeutic effectiveness; tool; two-dimensional

Project Summary: Aging increases the risk of GI disorders such as CRC, inflammatory bowel disease, and appendicitis. NIH statistic shows that 60 to 70 million people are affected by digestive diseases. Increasing global geriatric population base is expected to further worsen this situation over the coming years. Annually, diseases of the gastrointestinal (GI) tract account for more than 30 million office visits and more than 10 million GI endoscopic procedures in the United States alone for the examinations of digestive tract including the esophagus, stomach, small intestine, colon, and rectum. Minimally Invasive Surgery (MIS) endoscopes are still utilized as the main stream with close to $10 billon market needs and near double digit growth rate for performing both diagnosis and therapeutic clinic operations. Unfortunately, existing video based endoscopes can only provide 2D images for visual inspection purpose only, it cannot provide 3D quantitative information on volume and area and location of the disease, as well as the relative position of diagnostic and therapeutic equipment. To address this problem, Xyken together with its collaborator proposes to develop a novel imaging system to provide 2D/3D videoing of the GI anatomical structure. The proposed software system will have the following clinic impact and significance:  Greatly facilitating the diagnosis, planning, and treatment process through quantitative assessment, accurate depth perception and safer navigation  Providing more effective clinical training method for residents/doctors through in-vivo 3D digital GI tract model  Potentially replacing CT based image guided surgery – eliminating radiation and registration caused errors Published research reports find that, driven by the increasing number of the chronically ill population and aging, the global endoscopy equipment market is expected to reach USD 33.6 Billion by 2020 from USD 23.8 Billion in 2015, at a CAGR of 6.1%. With the aging population and advancement of the emerging economies, the global demand is expected to grow with an increased rate. The commercialization potential and economic impact of the proposed system is thus significant.

项目概要： 衰老会增加胃肠道疾病的风险，例如结直肠癌、炎症性肠病和 NIH 统计显示，有 60 至 7000 万人患有消化系统疾病。 全球老年人口基数的增加预计将在未来进一步恶化这种情况 每年因胃肠道疾病就诊的人数超过 3000 万人次。 仅在美国就进行了超过 1000 万次胃肠道内窥镜检查 消化道，包括食道、胃、小肠、结肠和直肠。 手术 (MIS) 内窥镜仍然是主流，市场需求接近 100 亿美元， 诊断和治疗诊所业务的增长率接近两位数。 不幸的是，现有的视频内窥镜只能提供用于目视检查的 2D 图像 仅出于目的，它无法提供有关体积、面积和位置的 3D 定量信息 疾病，以及诊断和治疗设备的相对位置。 问题，Xyken 与其合作者一起提议开发一种新颖的成像系统，以提供 GI 解剖结构的 2D/3D 视频 所提出的软件系统将具有以下功能。 临床影响及意义： Ø 通过定量极大地促进诊断、计划和治疗过程 评估、准确的深度感知和更安全的导航 Ø 通过活体3D数字化为住院医师/医生提供更有效的临床培训方法 胃肠道模型 Ø 有可能取代基于 CT 的图像引导手术——消除辐射和配准 造成错误 已发表的研究报告发现，在慢性病患者数量不断增加的推动下 随着人口和老龄化的影响，全球内窥镜设备市场预计将达到336亿美元 随着人口老龄化和社会进步，预计到 2020 年，这一数字将从 2015 年的 238 亿美元增至 6.1%。 新兴经济体的全球需求预计将以更高的速度增长。 因此，所提出的系统的商业化潜力和经济影响是巨大的。