Bioinformatics

生物信息学

• 批准号: 9149750
• 负责人: CHRISTOPHER B BURGE
• 金额: $ 38.16万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-07-09 至 2020-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9149750
• 关键词: Accounting; Bioinformatics; Budgets; Cancer Center; Cancer Center Support Grant; Complex; Computer software; Core Grant; Custom; Data; Data Set; Data Storage and Retrieval; Databases; Development; Funding; High Performance Computing; Housing; Image; Institutes; Investments; Maintenance; Methodology; Methods; Proteomics; Qualifying; Research; Research Project Grants; Research Support; Resource Sharing; Resources; Scientist; Services; Specialist; Training; Update; anticancer research; computer infrastructure; genome-wide; member; next generation sequencing; programs; screening; tool

Computational, bioinformatics and statistical capabilities are essential tools in cancer research, reflecting the widespread reliance on genome-wide approaches and the use of new methodologies, from imaging to highthroughput screening to next generation sequencing to proteomics, that generate increasingly complex data sets. The Bioinformatics & Computing Core (BCC) is a Shared Resource that provides both the computational infrastructure and expert bioinformatics and biostatistical support. The BCC is comprised of an outstanding team of staff scientists who contribute sophisticated bioinformatics and statistical analyses to research projects and/or provide expert training in these methods. Additionally, it provides access to an array of high performance computing, data storage server and software resources, as well as custom programming and database development to support the research programs of Center Members and also data intensive applications of other Koch Institute Cores. During the current period, the Koch Institute BCC was merged with the Bioinformatics efforts of three other MIT groups to create a shared Institutional BCC. Moreover, significant investments were made to update and expand both the high performance computing and data storage capabilities using MIT funds. This resulted in a significant expansion in capabilities and the diversity of staff expertise, including the addition of in-house biostatistical analyses. It also created significant economies of scale. Consequently the requested CCSG budget for Year 44 is 15% less than the requested and recommended budget in Year 39. Importantly, usage of the BCC by Center Members increased from 37% to 59% during the current period. Moreover, Center members account for 74% of the bioinformatics usage of the shared BCC even though the requested CCSG support for this Core is only 52% of the total stakeholder contributions.

计算、生物信息学和统计能力是癌症研究的重要工具，反映了 广泛依赖全基因组方法和新方法的使用，从成像到高通量 筛选到下一代测序到蛋白质组学，产生越来越复杂的数据 套。生物信息学和计算核心 (BCC) 是一个共享资源，提供计算 基础设施和专家生物信息学和生物统计支持。 BCC 由一群杰出的 为研究项目提供复杂的生物信息学和统计分析的科学家团队 和/或提供这些方法的专家培训。此外，它还提供对一系列高 性能计算、数据存储服务器和软件资源，以及定制编程和 数据库开发以支持中心成员的研究计划以及数据密集型 其他科赫研究所核心的应用。在此期间，科赫研究所 BCC 并入 麻省理工学院其他三个小组的生物信息学努力创建了一个共享的机构 BCC。此外，显着 投资更新和扩展高性能计算和数据存储 使用麻省理工学院资金的能力。这导致了人员能力和多样性的显着扩展 专业知识，包括增加内部生物统计分析。它还创造了显着的经济 规模。因此，所请求的第 44 年 CCSG 预算比所请求的和 15% 少 第 39 年建议的预算。重要的是，中心成员对 BCC 的使用从 37% 增加到 本期为 59%。此外，中心成员占该中心生物信息学使用量的74% 共享 BCC，即使为此核心请求的 CCSG 支持仅占利益相关者总数的 52% 贡献。