Molecular profiling of tumor tissue using targeted clinical proteomics

使用靶向临床蛋白质组学对肿瘤组织进行分子分析

• 批准号: 8157766
• 负责人: Donald Johann
• 金额: $ 12.61万
• 依托单位: DIVISION OF BASIC SCIENCES - NCI
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8157766
• 关键词: Clinical; Diagnosis; Economic Burden; Medical Economics; Molecular Profiling; Proteomics; Tumor Tissue

Our results have shown the ability to detect tumor residing proteins in the blood of a patient with a newly diagnosed non-metastatic cancer. In depth proteomic profiling of an individual patient's tumor for further elucidation of the particular molecular phenotype. A panel of putative markers are under investigation with high throughput techniques employing suitable immunoassays to test for general applicability to a much larger patient cohorts with this particular solid organ tumor. Such an approach facilitates maximization of therapeutic efficacy, minization of toxicities, and an attempt to reduce medical economic burdens.

我们的结果表明，有能力检测新诊断为非转移性癌症患者血液中蛋白质的肿瘤。深度对个体患者肿瘤的蛋白质组学分析，以进一步阐明特定的分子表型。一系列推定的标记正在研究，使用合适的免疫测定法进行高通量技术，以测试与这种特定的固体器官肿瘤对更大的患者同伙的一般适用性。这种方法促进了治疗功效的最大化，毒性的降低以及减轻医疗经济负担的尝试。