Estrogen metabolite profiling of thin tissue sections

薄组织切片的雌激素代谢谱分析

• 批准号: 8349414
• 负责人: Donald Johann
• 金额: $ 2.04万
• 依托单位: DIVISION OF BASIC SCIENCES - NCI
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8349414
• 关键词: Aromatase; Biological Assay; Biological Markers; Clinical; Estrogen Receptor Status; Estrogens; Freezing; Ligands; Malignant Neoplasms; Methods; Pathway interactions; Research; Signal Transduction; Solid Neoplasm; Tissues; Tumor Tissue; insight; receptor; steroid hormone; translational study; tumor

Many cancers are hormonally driven. Ultimately, a predictive assay combining information from tumor estrogen receptor status, mutational analysis, aromatase levels and estrogen metabolite analysis may prove to have clinical benefit. Estrogen metabolites profiled from tumor tissue may aid in evolving a strategy that targets cancer pathways in solid tumors by enhancing our understanding of estrogens produced locally via aromatase or via ligand dependent signaling. Ultimately, a rational co-inhibition of ER and related receptors may result in greater anti-tumor activity.

许多癌症是荷尔蒙驱动的。最终，一种预测分析结合了来自肿瘤雌激素受体状态，突变分析，芳香酶水平和雌激素代谢产物分析的信息可能具有临床益处。从肿瘤组织中介绍的雌激素代谢物可以通过增强我们对通过芳香酶或通过配体依赖性信号传导来靶向实体瘤的癌症途径的策略。最终，对ER和相关受体的合理共同抑制可能会导致更大的抗肿瘤活性。