Ovarian Hormones Effect on Smoking Behavior

卵巢激素对吸烟行为的影响

• 批准号: 8949348
• 负责人: Raina Pang
• 金额: $ 17.51万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-07-01 至 2020-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8949348
• 关键词: Abstinence; Address; Affect; Behavior; Car Phone; Cessation of life; Chronic Disease; Cigarette; Clinical; Clinical Trials; Controlled Study; Data; Decision Making; Dependence; Disease; Distal; Ecological momentary assessment; Emotions; Estrogens; Female; Goals; Grant; Health; Health Benefit; Health Care Costs; Hormonal; Hormonal Change; Hormone use; Hormones; Individual; Individual Differences; Investigation; Knowledge; Laboratories; Lead; Link; Luteal Phase; Maintenance; Manuscripts; Measures; Mediating; Mediator of activation protein; Menstrual cycle; Mentors; Mentorship; Methodology; Modeling; Moods; Morbidity - disease rate; Neurosecretory Systems; Nicotine; Nicotine Dependence; Outcome; Ovarian hormone; Pattern; Pharmaceutical Preparations; Pharmacotherapy; Phase; Phenotype; Positioning Attribute; Preparation; Preventive; Process; Progesterone; Protocols documentation; Reading; Research; Rewards; Risk; Risk Factors; Role; Running; Saliva; Sampling; Smoke; Smoker; Smoking; Smoking Behavior; Smoking Cessation Intervention; Staging; Students; Testing; Time; Tobacco Dependence; Tobacco smoking; Training; Variant; Withholding Treatment; Woman; addiction; base; cigarette smoking; cognitive control; design; disability; drug reward; experience; health disparity; improved; meetings; men; mind control; mortality; nicotine craving; novel; programs; proliferative phase Menstrual cycle; prospective; public health relevance; research study; sex; smoking cessation; smoking relapse; success

 DESCRIPTION (provided by applicant): Tobacco smoking is a leading cause of preventable death and disability in the U.S. Although women compared to men are at a greater risk of smoking-related disease morbidity and mortality, research suggests they may smoke for different reasons than men and have a harder time quitting than men. Research identifying female-specific factors underlying addiction is critical for: (a) addressing sex-related health disparities; (b) informing female-specific treatments; and (c) discovering addiction processes that are overrepresented among females yet applicable to both sexes. Ovarian hormones represent a female specific factor implicate in the maintenance of nicotine addiction and success following a quit attempt. This proposal aims to advance this line of research by combining ecological momentary assessment (EMA) with daily hormonal sampling across an entire menstrual cycle to further examine the patterns and mechanisms of ovarian hormone variation effects on smoking in women in real time. The use of prospective daily recordings and hormonal sampling will allow us to test whether smoking will be higher on days with high estrogen and lower on days with high progesterone (Aim 1), that women with greater estrogen to progesterone ratios compared to women with lower estrogen to progesterone ratios across the entire menstrual cycle will smoke more and be more nicotine dependent (Aim 2), and that days with higher estrogen will be marked by greater nicotine reward and worse cognitive control, which will mediate relations between higher estrogen and increased smoking (Aim 3). Secondary aims will explore variability of hormonal effects across the menstrual cycle (Aim 4). As the first comprehensive study investigating daily changes in ovarian hormones, drug reward, cognitive control, and smoking behavior, this project will pave the way for a program of research involving more intensive laboratory and field-based studies of psychoneuroendocrinological underpinnings of smoking in women. Through expert mentoring, directed readings, formal coursework and seminars, onsite training, attending national scientific meetings, manuscript and grant preparation, mentorship of students in the USC Health, Emotion, and Addiction Laboratory, and the completion of the proposed investigation expertise will be gained in: (a) Naturalistic field assessment of nicotine addiction; (b) EMA design and implementation; and (c) Use of advanced statistical methodology to test the aims outlined by the project. Thus, by the end of the proposed training period, the applicant will be uniquely positioned to run an independent interdisciplinary line of research incorporating both lab and field based studies in investigating female specific factors in addiction.

 描述（由申请人提供）：吸烟是美国可预防的死亡和残疾的主要原因。尽管与男性相比，女性患吸烟相关疾病的发病率和死亡率的风险更大，但研究表明，她们吸烟的原因可能与男性不同确定女性成瘾的具体因素对于以下方面至关重要：(a) 解决与性别相关的健康差异；(b) 提供针对女性的治疗方法；(c) 发现女性成瘾的过程；卵巢激素在女性中所占比例较高，但适用于两性，代表了与维持尼古丁成瘾和戒烟成功有关的女性特定因素。该提案旨在通过将生态瞬时评估（EMA）与每日激素评估相结合来推进这一研究。在整个月经周期进行采样，以进一步实时检查卵巢激素变化对女性吸烟影响的模式和机制。使用前瞻性每日记录和激素采样将使我们能够测试吸烟是否会更高。在雌激素高的日子和黄体酮高的日子里（目标 1），在整个月经周期中，与雌激素与黄体酮比率较低的女性相比，雌激素与黄体酮比率较高的女性会吸烟更多，并且更加依赖尼古丁（目标 2） ），而雌激素水平较高的日子将以更高的尼古丁奖励和较差的认知控制为标志，这将调节雌激素水平较高和吸烟增加之间的关系（目标 3）。作为第一个调查卵巢激素日常变化、药物奖励、认知控制和吸烟行为的综合研究，该项目将为涉及更深入的实验室和现场的研究计划铺平道路。通过专家指导、定向阅读、正式课程和研讨会、现场培训、参加国家科学会议、手稿和拨款准备、对学生的指导，对女性吸烟的心理神经内分泌基础进行研究。南加州大学健康、情绪和成瘾实验室以及完成拟议的调查专业知识将在以下方面获得：(a) 尼古丁成瘾的自然现场评估；(b) EMA 设计和实施；(c) 使用先进的统计方法因此，在拟议的培训期结束时，申请人将处于独特的地位，可以开展独立的跨学科研究，结合实验室和实地研究来调查女性成瘾的具体因素。