Pesticide Exposure and Childhood Autism

农药接触与儿童自闭症

• 批准号: 8638824
• 负责人: Ondine von Ehrenstein
• 金额: $ 18.45万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-12-05 至 2015-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8638824
• 关键词: Address; Age; Age-Months; Agriculture; Area; Autistic Disorder; Birth; Birth Certificates; Birth Records; California; Carbamates; Chemicals; Child; Childhood; Chlorinated Hydrocarbons; Client; Complex; Data; Data Set; Databases; Development; Developmental Disabilities; Diagnosis; Disease; Electronics; Endocrine Disruptors; Enrollment; Environment; Environmental Health; Environmental Risk Factor; Exposure to; Fetal Development; Gender; Genes; Geographic state; Goals; Health; Health Policy; Human; Individual; Location; Malignant Childhood Neoplasm; Maps; Measures; Methods; Neurodevelopmental Disorder; Organophosphates; Parents; Participant; Perinatal Exposure; Pesticides; Population; Population Control; Pregnancy; Prevalence; Primary Prevention; Production; Radial; Records; Regulation; Reporting; Research; Resources; Risk; Role; Sampling; Scientific Advances and Accomplishments; Services; System; Techniques; Testing; Time; Toxic Environmental Substances; Toxin; base; cohort; experience; improved; insight; land use; meter; neurodevelopment; neurotoxic; pesticide exposure; population based; prenatal; public health relevance; residence; sex; suburb; tool

Project summary/Abstract Autism is one of the most common neurodevelopmental disorders with a prevalence of ~40- 60 in 10,000 in children in the US (5, 11). Both genes and environmental factors contribute to this complex disorder (13) with recent research suggesting a stronger role for environmental factors (14). However, the role of environment remains elusive even though the public is very concerned. Population-based research applying valid and reliable exposure assessment methods is thoroughly needed. Here, we propose to examine the hypothesis that exposure to specific pesticides during vulnerable periods, particularly during fetal development, determines risks of subsequent development of autistic disorder (AD). California is an excellent location for studying potential environmental contributions to AD. The California Department of Developmental Services (CA-DDS) operates a statewide system of regional centers for autism services and maintains electronic records for all clients. California ranks 1st among US states in agricultural production, with 1/4 of total agricultural pesticide use in the US (15, 16), and is the only state which maintains a statewide pesticide use reporting system. Building onto this unique resource, our group has over 15 years of experience studying health effects from pesticides in California. Previously, we developed a geographic pesticide exposure assessment tool (GRAPES) that utilizes the unique California Pesticide Use Report system, in combination with agricultural land-use maps, to derive record-based estimates of historical residential exposures (17, 18), allowing us to capture month/trimester specific agricultural pesticide exposures statewide. Statewide, we expect to identify >20,000 autism cases with diagnoses up to the age of 72 months from the CA-DDS database born in CA 1997-2009 and >1,700 from agricultural areas as well as 1:10 age-sex match controls from birth records (51). This will provide the largest cohort ever to address hypotheses that exposures to specific chemicals (e.g. neurotoxic or endocrine disrupting agents) contribute to AD during vulnerable periods of development. Specifically, we will examine whether AD is associated with peri-conceptional and fetal exposures to specific pesticides, focusing neurodevelopmental toxins as well as high volume use pesticides; applying sophisticated record based exposure assessment techniques to determine pesticide exposures while avoiding recall bias due to over-reporting of exposures among case parents. We have available the to-date most refined, state-of-the-art objective pesticide assessment tool that provides us with individual level exposures during an extended observation period, in a large area and for a large population (the state of California). Improving our understanding of impacts of environmental toxins will inform environmental health policy on pesticide regulation, advance primary prevention of autism, and potentially provide scientific insights into biologic mechanisms of autism development.

项目摘要/摘要 自闭症是最常见的神经发育障碍之一，患病率约为40-60 美国儿童有10,000名（5，11）。基因和环境因素都导致这种复杂的疾病 （13）最近的研究表明环境因素的作用更强（14）。但是， 即使公众非常担心，环境仍然难以捉摸。基于人群的研究应用 非常需要有效可靠的暴露评估方法。在这里，我们建议检查 假设在脆弱时期，尤其是胎儿期间暴露于特定农药 开发，决定了随后的自闭症患者（AD）的风险。 加利福尼亚是研究广告潜在的环境贡献的绝佳地点。这 加利福尼亚州发展服务部（CA-DDS）为全州范围内的地区中心制度 自闭症服务并维护所有客户的电子记录。加利福尼亚在美国中排名第一 农业生产，在美国拥有1/4的农用农药使用（15、16），是唯一的州 维护全州农药使用报告系统。建立在这个独特的资源上，我们的小组有 在加利福尼亚州研究健康影响的15年以上。以前，我们开发了 使用独特的加利福尼亚农药使用的地理农药暴露评估工具（葡萄） 报告系统与农业土地利用地图结合起来得出基于记录的历史估计值 住宅暴露（17，18），使我们能够捕获一个月/妊娠的特定农业农药暴露 全州。 在全州，我们预计将确定> 20,000例自闭症病例，并从72个月内诊断出 CA-DDS数据库出生于1997 - 2009年的CA和> 1,700，来自农业区以及1:10年龄段的比赛 从出生记录中控制（51）。这将提供有史以来最大的队列来解决暴露的假设 对于特定的化学物质（例如神经毒性或内分泌剂）在脆弱期间有助于AD 发展时期。具体而言，我们将检查AD是否与孕期和胎儿有关 暴露于特定农药，聚焦神经发育毒素以及大量使用农药； 应用基于复杂的记录的暴露评估技术来确定农药暴露 由于案件父母之间的暴露过度报告，避免召回偏见。我们最早获得了最新的 精致的，最先进的客观农药评估工具，可为我们提供个人水平的暴露 在延长的观察期间，在大面积和大量人口（加利福尼亚州）。 提高我们对环境毒素影响的理解将为环境健康政策提供信息 农药调节，预防自闭症的主要预防，并有可能提供科学见解 自闭症发展的生物学机制。