Tissue Bank and Biomarkers Core

组织库和生物标志物核心

基本信息

批准号：
8664640
负责人：
Daniel Thomas Merrick
金额：
$ 26.12万
依托单位：
UNIVERSITY OF COLORADO DENVER
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/8664640
关键词：
Adenocarcinoma Archives Belief Bioinformatics Biological Biological Markers Biological Preservation Biometry Biostatistics Core Blood Body Fluids Cancer Center Characteristics Chemopreventive Agent Classification Clinic Clinical Clinical Trials Collaborations Collection Colorado Confidentiality Confidentiality of Patient Information Consent Core Facility Cytogenetics DNA Data Data Analyses Databases Diagnosis Diagnostic Disease Disease Progression Dissection Drug or chemical Tissue Distribution Dysplasia Exhalation Extramural Activities Generations Goals Guidelines Health Insurance Portability and Accountability Act Histologic Histology Human Resources Human body In Situ Hybridization Informatics Institutional Review Boards Intervention Knowledge Laboratories Lesion Link Lung Lung Neoplasms Malignant - descriptor Malignant neoplasm of lung Maps Medical Molecular Molecular Analysis Molecular Genetics Neuroendocrine Tumors Nucleic Acids Outcome Participant Pathologic Pathologist Patients Performance Premalignant Process Process Measure Proteins Proteomics Protocols documentation Publications Publishing RNA Research Research Design Research Infrastructure Research Personnel Resource Sharing Resources Sampling Services Specimen Specimen Handling Sputum System Testing The University of Colorado Cancer Center Therapeutic Tissue Banking Tissue Banks Tissue Microarray Tissues Translational Research Translations Tumor Bank Tumor Subtype United States National Institutes of Health Universities Urine Variant Work biobank cost design high risk human tissue laser capture microdissection meetings member molecular pathology operation organizational structure prevent programs repository response success tissue processing tool tumor validation studies

项目摘要

The Tissue Bank and Biomarkers Core (TBBC) is the central repository of specimens necessary for the execution of the studies of the Colorado SPORE In Lung Cancer program. Furthermore, as an extensive resource for lung cancer related specimens, the TBBC also provides specimens to extramural investigators when there are adequate materials to accommodate these requests beyond the needs of the internal projects. The three primary goals of the TBBC are to procure, characterize and process, and distribute specimens. The provision of these services takes advantage of a close working relationship with the existing facilities, infrastructure, and personnel for biobanking and histology operations of the University of Colorado Cancer Center Tissue Biobanking and Processing Shared Resource. Two general banks are maintained: a tumor bank and a premalignant bank. Specimens for both of these banks are collected as archival tissue or, in collaboration with the Clinical Trials Core, SPORE trial associated specimens and are obtained under IRB approved protocols. In addition to tissue, ancillary specimens including blood, sputa, urine and special bronchoscopic specimens are collected. The TBBC, in collaboration with the Biostatistics and Bioinformatics core of the SPORE, also collects correlative clinical and biologic information that can be included in specimen distributions. The TBBC provides histologic and cytologic interpretation, prepares RNA, DNA and protein samples, creates TMAs and provides molecular analysis on selected specimens required by the SPORE projects. This includes histologic review and classification by up-to-date published WHO classification systems for malignant and pre-malignant lesions of the lung by the pathologist members of the core. The core designs its activities to meet the needs of each of the SPORE projects as outlined In the proposal. In order to meet the tissue needs and achieve the goals of the projects, the TBBC collects and processes tissues in a specific manner as determined via collaboration with project investigators. The TBBC also collaborates in the performance of project related studies in which expertise of TBBC personnel can benefit study design, data generation, and data analysis.

组织库和生物标志物核心（TBBC）是执行科罗拉多州孢子研究中肺癌计划中必要的标本的中央存储库。此外，作为与肺癌相关标本的广泛资源，TBBC还为壁外研究人员提供标本，当有足够的材料适应内部项目需求以外的这些请求时。 TBBC的三个主要目标是采购，表征和处理并分发标本。这些服务的提供利用了科罗拉多大学癌症中心组织生物群和加工共享资源的现有设施，基础设施以及生物群和组织学运营人员的密切工作关系。维持了两家一般银行：一家肿瘤银行和一家预先立即的银行。这两家银行的标本都是作为档案组织收集的，或与临床试验核心合作，与孢子试验相关标本，并根据IRB批准的协议获得。除组织外，还收集了包括血液，痰，尿液和特殊支气管镜标本在内的辅助标本。 TBBC与孢子的生物统计学和生物信息学核心合作，还收集了可以包含在样品分布中的相关临床和生物学信息。 TBBC提供了组织学和细胞学解释，准备RNA，DNA和蛋白质样品，创建TMA，并对孢子项目所需的选定标本提供分子分析。这包括最新发布的组织学审查和分类WHO核心成员病理学家对肺部恶性病变和恶性病变的分类系统。核心设计其活动以满足提案中概述的每个孢子项目的需求。为了满足组织需求并实现项目的目标，TBBC以与项目研究人员的合作确定的特定方式收集和处理组织。 TBBC还合作了项目相关研究的性能，其中TBBC人员的专业知识可以使研究设计，数据生成和数据分析受益。