Epidemiologic Research on Screening for Vestibular and Balance Disorders

前庭和平衡障碍筛查的流行病学研究

• 批准号: 8884949
• 负责人: Helen S COHEN
• 金额: $ 62.82万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2020-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8884949
• 关键词: AIDS/HIV problem; Academic Medical Centers; Acquired Immunodeficiency Syndrome; Adult; Age; Age-Years; American; Astronauts; Bed rest; Bisexual; Clinic; Cohort Studies; Communicable Diseases; Communities; Community Health Centers; Computer software; Controlled Environment; Data Collection; Development; Diagnostic; Diagnostic tests; Disease; Distant; District of Columbia; Elderly; Environment; Epidemiologic Studies; Epidemiology; Equilibrium; Frequencies; Funding; Future; General Population; Goals; Gold; Grant; HIV; Head; Head Movements; Health; Healthcare; Hearing problem; Homosexuals; Impairment; Laboratories; Labyrinth; Language; Learning; Left; Low income; Manuals; Measures; Medicine; Methods; Minority; NIH Program Announcements; National Institute on Deafness and Other Communication Disorders; Natural History; Nursing Homes; Participant; Patients; Population; Predictive Value; Predictive Value of Tests; Prospective Studies; Public Health; Quality of Care; Recruitment Activity; Reference Values; Research; Resources; Running; Scoring Method; Sensitivity and Specificity; Sex Characteristics; Site; Smell Perception; Space Flight; Speech; Stimulus; Strategic Planning; Symptoms; System; Tablet Computer; Taste Perception; Test Result; Testing; Tetanus Helper Peptide; Time; Training; Translating; Underserved Population; United States National Institutes of Health; Validation; Vestibular Diseases; Visual Acuity; Voice; Walking; Woman; Work; Writing; bench to bedside; college; equilibration disorder; ethnic difference; improved; inner ear diseases; instrument; kinematics; member; men; middle age; otoconia; population based; prospective; public health relevance; racial difference; research clinical testing; response; screening; sensor; sensory integration; seropositive; software development

 DESCRIPTION (provided by applicant): The long-term goal of this study is to develop valid and reliable tests for screening people for vestibular (inner ear) disorders, so that those tests can be used in studies of the American population to determine the frequency of vestibular disorders in the general population. We also expect that these tests will be useful in nursing homes and other facilities with limited resources for testing, and at landing sites for astronauts after returning from long duration space flight. In Specific Aim 1 we will complete test development, including developing age-appropriate norms for a test of standing balance, and we will determine which tests best distinguish healthy controls from people with known vestibular disorders. In Specific Aim 2 we will test the test battery, to determine how well the tet battery predicts who in the general population has a vestibular impairment. Participants will be given the test battery and then will be tested in the diagnostic laboratory with the standard battery of objective diagnostic tests. Using the new test battery in Specific Aim 2A we will screen people recruited from clinics at Baylor College of Medicine. The screening environment at Baylor College of Medicine will be well-controlled so that we will be able to work out any technical bugs in the system. Using the new screening battery we will also test people at a distant site, the Washington, DC site of the Women's Interagency HIV Study (WIHS). The WIHS includes participants who have HIV or AIDS and participants who are age-matched healthy controls. At this site we will have less control over the screening environment but will work with an excellent, well-established epidemiologic team to determine not only how well the tests predict results from the diagnostic laboratory but also how easy the battery is for staff to administer. Additional benefits of testing the WIHS cohort, men recruited from the Infectious Disease clinic at Georgetown University Medical Center, and men from the community who do not have HIV/AIDS, will be the ability to learn more about the effects of HIV/AIDS on vestibular disorders in middle-aged and early-elderly people who also represent underserved populations that are rarely, if ever, invited to participate in research on vestibular and balance disorders, ie., homosexual/ bisexual men and low-income, minority women in the WIHS. Because these tests may also be used in community health centers where homosexual/ bisexual men and low income, minority women with HIV/AIDS often receive health care developing these tests may improve the quality of care available to those subpopulations.

 描述（由适用提供）：这项研究的长期目标是为筛查前庭（内耳）疾病的人开发有效可靠的测试，以便可以将这些测试用于美国人群的研究中，以确定普通人群中前庭疾病的频率。我们还期望这些测试在护士之家和其他设施中有限的测试资源，以及从长时间延长空间飞行返回后的宇航员的着陆点。在特定目标1中，我们将完成测试开发，包括制定适合年龄的规范来测试常规平衡，我们将确定哪些测试最能将健康控制与已知前庭疾病的人区分开。在特定的目标2中，我们将测试测试电池，以确定一般人群中的TET电池预测对前庭障碍的预测效果如何。将对参与者进行测试电池，然后通过标准的客观诊断测试在诊断实验室进行测试。在特定的AIM 2A中使用新的测试电池，我们将筛选 从贝勒医学院的诊所招募的人。贝勒医学院的筛查环境将得到充分控制，以便我们能够确定系统中的任何技术错误。使用新的筛选电池，我们还将在妇女间艾滋病毒研究（WIHS）的华盛顿特区华盛顿特区遥远的地点进行测试。 WIHS包括患有艾滋病毒或艾滋病的参与者和与年龄匹配的健康对照者的参与者。在此网站上，我们将对筛查环境的控制权减少，但将与一个出色的，完善的流行病学团队合作，不仅确定测试的预测诊断实验室的结果，而且还可以确定电池对员工的容易程度。测试WIHS队列的其他好处，乔治敦大学医学中心从感染性疾病诊所招募的男性以及没有艾滋病毒/艾滋病的社区的男人将是能够更多地了解艾滋病毒/艾滋病对中期和早期人群中的艾滋病的影响，并表现出既定不断的人群的影响，并参与了既定不断的人，如果是平衡的，则是既定不足的，如果是平衡的，则是既定不足的，如果是平衡的，则是对艾滋病的疾病的参与。即，同性恋/双性恋男人和低收入的男性，少数族裔女性。由于这些测试也可以在同性恋/双性恋男性和低收入的社区卫生中心中使用，因此患有艾滋病毒/艾滋病的少数民族妇女经常获得开发这些测试的医疗保健，可能会改善这些子人群可用的护理质量。