Epidemiologic Research on Screening for Vestibular and Balance Disorders

前庭和平衡障碍筛查的流行病学研究

• 批准号: 8050074
• 负责人: Helen S COHEN
• 金额: $ 29.83万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2013-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8050074
• 关键词: Acute; Adult; Caloric Tests; Clinic; Complex; Computer software; Data; Development; Diagnostic; Diagnostic tests; Discontinuous Capillary; Disease; Environment; Epidemiologic Studies; Epidemiology; Equilibrium; Equipment; Frequencies; Funding; Future; General Population; Head; Health; Hearing problem; Hospitals; Impairment; Laboratories; Language; Lower Extremity; Marines; Mediating; Medical; Military Personnel; Motor; NIH Program Announcements; National Institute on Deafness and Other Communication Disorders; Occupations; Patients; Peripheral Nervous System Diseases; Physicians; Physiological; Physiology; Population; Prevalence; Recruitment Activity; Rehabilitation therapy; Research; Rotation; Safety; Sampling; Screening procedure; Simulate; Smell Perception; Specialist; Speech; System; Taste Perception; Testing; Time; Training; United States; Visual; Visual Acuity; Voice; Walking; Work; computerized; distraction; equilibration disorder; high risk; meetings; oculomotor; population based; programs; response; sensor; tertiary care

DESCRIPTION (provided by applicant): The proposed study, a response to PA-06-257, will develop tests for use in epidemiologic studies of vestibular and balance function, and other applications in which comprehensive vestibular testing is not possible. This study will meet the requirements of the Program Announcement with the following specific aims: 1) Equipment and test development. Develop a battery of screening tests that are sensitive and specific to vestibular disorders. To meet the practical needs of future population-based epidemiologic studies, this test battery will be brief, i.e., taking less than 15 minutes, and will be performed in a space no more than 8 X 1 m. Tests of standing and walking balance and dynamic visual acuity will be included. We will develop new versions of existing tests, and will include technological development, i.e., programming new software for tests and use of head-mounted sensors, testing all apparatus for safety. We will also develop norms for all tests. This aim is largely technologically driven, not hypothesis driven. 2) Validate the new battery of screening tests. 2A) Determine if these screening tests differentiate normals from the same normals when they are given galvanic vestibular stimulation to simulate acute vestibular impairment. 2B) Determine if normals who are well trained to perform at a high level despite distraction and discomfort, i.e., United States Marines, show differences on the new test battery when tested with and without galvanic vestibular stimulation. 2C) Determine if these screening tests differentiate normals from patients with known vestibular impairments. 2D) Determine if these balance tests differentiate patients with vestibular impairments from patients with lower extremity peripheral neuropathies. 3) Estimate prevalence of vestibular impairment in two adult populations and determine if the new screening battery, i.e., the 3 screening tests plus 2 other well-validated tests, detects vestibular disorders in those populations. 3A) Determine prevalence of vestibular disorders and sensitivity of the screening battery in a sample of the general population recruited from a general medical clinic. 3B) Determine prevalence of vestibular disorders and sensitivity of the screening battery in a sample of high-functioning people in high-risk occupations recruited in a military health clinic. 4) Determine if these screening tests are sensitive to change after vestibular rehabilitation. Subjects will be tested before and after a month of vestibular rehabilitation. The vestibular system may be assessed with a wide range of objective diagnostic tests in laboratories in hospitals, tertiary care centers or even smaller clinician's offices, when space, complex equipment and staff may be available to accommodate the physician's request for diagnostic data and the unique needs of each patient. Sometimes, however, such a comprehensive test battery cannot be given due to constraints of funding, space, and/ or time. In this study we will develop and validate screening tests of the vestibular system that will be useful to testing large numbers of people by busy staff who will not be vestibular or balance specialists and whose work will be constrained by limited time, space for testing, and funds for equipment. PUBLIC HEALTH RELEVANCE: The vestibular system may be assessed with a wide range of objective diagnostic tests in laboratories in hospitals, tertiary care centers or even smaller clinician's offices, when space, complex equipment and staff may be available to accommodate the physician's request for diagnostic data and the unique needs of each patient. Sometimes, however, such a comprehensive test battery cannot be given due to constraints of funding, space, and/ or time. In this study we will develop and validate screening tests of the vestibular system that will be useful to testing large numbers of people by busy staff who will not be vestibular or balance specialists and whose work will be constrained by limited time, space for testing, and funds for equipment.

描述（由申请人提供）：拟议的研究是对PA-06-257的回应，将开发用于前庭和平衡功能流行病学研究的测试，以及其他不可能进行全面前庭测试的应用。这项研究将满足计划公告的要求，并具有以下特定目的：1）设备和测试开发。开发一系列敏感且对前庭疾病特异的筛查测试。为了满足未来基于人群的流行病学研究的实际需求，该测试电池将简短，即需要不到15分钟，并且将在不超过8 x 1 m的空间中进行。将包括站立平衡和动态视力的测试。我们将开发现有测试的新版本，并包括技术开发，即编程新软件，用于测试和使用头部安装的传感器，对所有设备进行安全性测试。我们还将为所有测试制定规范。这个目标在很大程度上是技术驱动的，而不是驱动假设的。 2）验证新的筛选测试电池。 2a）确定这些筛选测试是否在给予电力前庭刺激以模拟急性前庭障碍时将它们与同一正常质量区分开。 2b）确定尽管有分心和不适，即接受高水平的训练的正常训练，即美国海军陆战队是否在接受有或没有电力前庭刺激的新测试电池上显示出差异。 2C）确定这些筛查测试是否将正常性与已知前庭障碍患者区分开。 2d）确定这些平衡测试是否将前肢神经病患者的前庭障碍患者与患者区分开。 3）估计两个成年人群中前庭障碍的患病率，并确定新的筛选电池是否（即3次筛选测试以及其他2项验证测试）检测到这些人群中的前庭疾病。 3A）确定从一般医疗诊所招募的一般人群样本中前庭疾病的患病率和筛查电池的灵敏度。 3b）确定前庭疾病的患病率和筛查电池的敏感性，在军事健康诊所招募的高风险职业中的高功能人群样本中。 4）确定这些筛查测试是否对前庭康复后的变化敏感。在一个月的前庭康复之前和之后，将对受试者进行测试。可以通过在医院，三级护理中心甚至较小的临床医生办公室的实验室进行广泛的客观诊断测试来评估前庭系统，何时可以使用空间，复杂的设备和人员来适应医生的诊断数据要求以及每个患者的独特需求。但是，有时由于资金，空间和/或时间的限制，无法给出这样的全面测试电池。在这项研究中，我们将开发和验证前庭系统的筛选测试，这将对忙碌的员工测试大量人员有用，而繁忙的员工将不会是前庭或平衡专家，并且他们的工作将在有限的时间，测试空间和设备资金的情况下受到限制。公共卫生相关性：可以通过在医院，三级护理中心甚至较小的临床医生办公室的实验室进行广泛的客观诊断测试来评估前庭系统，何时可以使用空间，复杂的设备和员工来适应医生的要求，以适应医生的诊断数据和每个患者的独特需求。但是，有时由于资金，空间和/或时间的限制，无法给出这样的全面测试电池。在这项研究中，我们将开发和验证前庭系统的筛选测试，这将对忙碌的员工测试大量人员有用，而繁忙的员工将不会是前庭或平衡专家，并且他们的工作将在有限的时间，测试空间和设备资金的情况下受到限制。