Differential Effects of Exercise Modality on Cognition and Brain in Older Adults

运动方式对老年人认知和大脑的不同影响

基本信息

批准号：
10097536
负责人：
Amanda N. Szabo-Reed
金额：
$ 137.53万
依托单位：
UNIVERSITY OF KANSAS MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-04-01 至 2026-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10097536
关键词：
Address Aerobic Aerobic Exercise Age Age-associated memory impairment Aging Alzheimer&apos s Disease American Americas Attenuated Bioenergetics Biological Biological Markers Blood Chemical Analysis Blood Platelets Body Composition Body fat Brain Brain-Derived Neurotrophic Factor Centers for Disease Control and Prevention (U.S.)Cerebrovascular Circulation Cities Clinical Clinical Trials Cognition Cognitive Communities Consensus Dementia Development Dose Elderly Enrollment Equilibrium Exercise Fatty acid glycerol esters Functional Magnetic Resonance Imaging Future Gait Goals Health Care Costs Health Policy Health education Healthcare Systems Impaired cognition Individual Insulin Resistance Insulin-Like Growth Factor I Kansas Knowledge Life Link Maintenance Measures Mediating Modality Multi-Institutional Clinical Trial Muscle function Neuropsychology Oxygen Consumption Participant Phase Physical Exercise Physical Function Physical activity Physiological Plasma Public Health Quality of life Randomized Recommendation Research Resistance Resources Rest Science Spin Labels Structure Testing Translating United States National Institutes of Health Walking Weight Lifting active lifestyle aging population arm base brain health brain volume cardiorespiratory fitness cognitive benefits cognitive function cognitive performance community setting exercise intervention exercise program exercise training experience flexibility functional gain group intervention hippocampal atrophy improved mode of exercise muscle form muscle strength physical conditioning prevent programs resistance exercise strength training

项目摘要

Project Summary Older adults often experience physical decline that can be directly ameliorated by physical activity and exercise. Evidence is building that exercise prevents cognitive decline or delays the onset of debilitating dementia (e.g. Alzheimer's disease [AD]) yet, the optimal dose and combination of exercise modalities for promoting brain health, however, remains unknown and essentially untested. Our long-term research goal is to develop and test strategies to support successful aging and prevent AD. We have successful ongoing (R01AG053312, R01AG053952, R01AG049749, R01AG52954, R01AG043962) and completed projects (R01AG033673, R01AG034614, KL2TR000119) around a theme of community-based exercise programs for older adults. We will enroll 280 individuals, age 65 to 80 years without cognitive impairment, into a 52-week exercise intervention to test the combined and independent effects of aerobic and resistance training on cognition, brain structure, and physical function. We will also explore underlying biological mechanisms that may link exercise with brain health. Participants will be randomized into 1 of 4 groups: flexibility, toning and balance (control), aerobic exercise training, progressive resistance training, or combined aerobic and resistance training. All intervention groups represent the most common modalities of exercise and directly reflect the public health recommendations for aerobic and resistance training. Exercise training will occur in a community setting through the network of Greater Kansas City YMCAs. We hypothesize that 52 weeks of exercise will improve 1) cognitive performance, 2) regional brain volume, 3) cardiorespiratory fitness and strength 4) biomarkers. This will be the largest study to assess the combined and independent effects of the two most recommended forms of exercise. Demonstrating specific exercise effects on cognitive function and brain health in older adults would have enormous public health implications. The study's results will also impact public health policy and education by providing evidence towards the specific or synergistic effects of aerobic and resistance training on cognition and brain structure. Encouraging the public to adapt more active lifestyles and stimulate the development of effective exercise delivery programs to enhance initiation and maintenance of physical activity interventions is key to increasing the number of quality years of life for America's aging population.

项目概要老年人经常会经历身体衰退，可以通过身体锻炼直接改善活动和锻炼。越来越多的证据表明，锻炼可以预防认知能力下降或延缓认知障碍的发生衰弱性痴呆（例如阿尔茨海默病 [AD]），最佳剂量和运动组合然而，促进大脑健康的方式仍然未知，并且基本上未经测试。我们的长期研究目标是开发和测试支持成功老龄化和预防AD。我们已经成功进行中（R01AG053312、R01AG053952、R01AG049749、R01AG52954、 R01AG043962）和已完成的项目（R01AG033673、R01AG034614、KL2TR000119）围绕主题针对老年人的社区锻炼计划。我们将招募280名年龄在65岁至80岁之间的人在没有认知障碍的情况下，进行为期 52 周的运动干预，以测试综合和独立运动有氧运动和阻力训练对认知、大脑结构和身体功能的影响。我们也会探索可能将运动与大脑健康联系起来的潜在生物机制。参与者将被随机分为 4 组中的一组：灵活性、塑身和平衡（对照）、有氧运动运动训练、渐进式阻力训练或有氧与阻力相结合的训练。所有干预群体代表了最常见的锻炼方式，直接反映了公众的健康状况有氧运动和阻力训练的建议。运动训练将在社区环境中进行通过大堪萨斯城基督教青年会网络。我们假设 52 周的锻炼会有所改善 1) 认知表现，2) 区域脑容量，3) 心肺健康和力量 4) 生物标志物。这将是评估两个最重要因素的综合和独立影响的最大规模的研究推荐的锻炼方式。展示特定运动对认知功能和大脑的影响老年人的健康将对公共卫生产生巨大影响。研究结果也将影响通过提供有氧运动的具体或协同效应的证据来制定公共卫生政策和教育以及针对认知和大脑结构的阻力训练。鼓励公众适应更积极的生活方式并刺激制定有效的锻炼计划，以加强启动和维持身体活动干预措施是提高美国老龄化人口的优质生活年数的关键人口。