CLINICAL EVALUATION OF SURFACTANT GENE MUTATIONS

表面活性剂基因突变的临床评估

• 批准号: 7731403
• 负责人: WILLIAM Bradford LAWSON
• 金额: $ 0.03万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7731403
• 关键词: Computer Retrieval of Information on Scientific Projects Database; First Degree Relative; Funding; Gene Mutation; Goals; Grant; Individual; Institution; Interstitial Lung Diseases; Mutation; Natural History; Research; Research Personnel; Resources; Source; Staging; Symptoms; Testing; United States National Institutes of Health; research clinical testing; surfactant

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Our hypothesis is that half of the first degree relatives of this individual will carry this SFTPC mutation, and that a portion of these may have evidence of interstitial lung disease in an early stage before symptoms have developed. Our goal is to identify presymptomatic interstitial lung disease, then perform serial annual testing to determine the natural history.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 我们的假设是，该个体的一半一级亲属将携带这种 SFTPC 突变，并且其中一部分可能在症状出现之前的早期阶段就有间质性肺疾病的证据。 我们的目标是识别症状前的间质性肺疾病，然后进行连续的年度测试以确定自然史。