PILOT STUDY OF DBS FOR TREATMENT-REFRACTORY OCD

DBS 治疗难治性强迫症的试点研究

• 批准号: 7717076
• 负责人: Wayne K Goodman
• 金额: $ 4.77万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-12-01 至 2008-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7717076
• 关键词: Adverse effects; Anterior; Behavior Therapy; Bilateral; Chronic; Cognitive Therapy; Computer Retrieval of Information on Scientific Projects Database; Country; Data; Deep Brain Stimulation; Disease; Effectiveness; European; Funding; Goals; Grant; Implanted Electrodes; Institution; Internal Capsule; Intervention; Invasive; Lead; Left; Limb structure; Numbers; Obsessive-Compulsive Disorder; Operative Surgical Procedures; Patients; Procedures; Qualifying; Quality of life; Refractory; Reporting; Research; Research Personnel; Research Project Grants; Resources; Risk; Safety; Severities; Source; Symptoms; Techniques; United States National Institutes of Health; brain tissue; design; improved; neurosurgery

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal of this research project is to reduce symptom severity and enhance quality of life for subjects with severe and intractable obsessive-compulsive disorder (OCD). Despite advances in the pharmacological and behavioral therapies, a substantial number of patients fail to improve significantly following years of conventional as well as experimental interventions. For some patients, stereotactic neurosurgery is the only promising option left. The available evidence suggests that these procedures may lead to enduring benefits and relatively few side effects in the majority of OCD patients with intractable disease. However, the effects of these ablative techniques on brain tissue and function are irreversible. A team of European investigators reported positive results in three of four intractable cases of OCD using bilateral deep brain stimulation (DBS) of the anterior limb of the internal capsule. Independent confirmation by a qualified psychiatric-neurosurgical team is crucial before it gains more widespread use; there are already indications that numerous centers across the country are pursuing it. Although DBS, like ablative surgery, is an invasive procedure with infrequent but serious risks, unlike ablative techniques, DBS is adjustable and partially reversible. The current project is designed to gather preliminary data on the effectiveness, safety, and tolerability of chronic stimulation (DBS) via bilaterally implanted electrodes in the anterior limb of the internal capsules of 6 subjects with treatment-refractory OCD that would otherwise be candidates for ablative neurosurgery.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 该研究项目的目标是减轻严重难治性强迫症 (OCD) 患者的症状严重程度并提高其生活质量。尽管药物和行为疗法取得了进步，但经过多年的常规和实验干预后，仍有大量患者未能显着改善。对于一些患者来说，立体定向神经外科手术是唯一有希望的选择。现有证据表明，这些手术可能会给大多数患有顽固性疾病的强迫症患者带来持久的益处和相对较少的副作用。然而，这些消融技术对脑组织和功能的影响是不可逆转的。欧洲研究小组报告称，使用内囊前肢双侧深部脑刺激（DBS）治疗四例顽固性强迫症病例中的三例，结果呈阳性。在获得更广泛的使用之前，由合格的精神科神经外科团队进行独立确认至关重要；已经有迹象表明，全国各地的许多中心都在推行这一举措。尽管 DBS 与消融手术一样，是一种侵入性手术，风险虽少，但风险严重，但与消融技术不同，DBS 是可调节的且部分可逆。当前的项目旨在收集关于通过双侧植入电极在内囊前肢进行慢性刺激 (DBS) 的有效性、安全性和耐受性的初步数据，这些电极患有治疗难治性强迫症，否则将成为消融治疗的候选者。神经外科。