Training Interventions and Genetics of Exercise Response (TIGER)

训练干预和运动反应遗传学（TIGER）

• 批准号: 8085929
• 负责人: Molly Bray
• 金额: $ 70.83万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-15 至 2015-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8085929
• 关键词: 13 year old; Adherence; Adipose tissue; Adolescence; Adolescent; Adult; Age; Animals; Area; Behavior; Body Composition; Body Weight; Body Weight decreased; Body mass index; Breeding; Candidate Disease Gene; Child; Childhood; Cognitive; Development; Dropout; Drops; Educational Intervention; Educational process of instructing; Evaluation; Exercise; Exposure to; Fatty acid glycerol esters; Gender; Gene Expression; Genes; Genetic; Genetic Variation; Glucose; Goals; Habits; Health behavior; Heritability; Home environment; Human; Individual; Intervention; Intervention Studies; Investigation; Joints; Learning; Leukocytes; Life; Lipids; Maximum Heart Rate; Measures; Mediating; Mental Depression; Molecular; Muscle; Obesity; Overweight; Participant; Patient Self-Report; Pattern; Peripheral; Persons; Phase; Physical activity; Physiological; Plasma; Population; Prevalence; Probability; Protocols documentation; Public Health; Race; Regulation; Research Design; Rodent; Signal Transduction; Skeletal Muscle; Time; Training; Universities; Variant; Weight; Weight Gain; age group; base; behavior change; college; design; empowered; genetic analysis; improved; meetings; programs; psychologic; public health relevance; relating to nervous system; response; sedentary; social; subcutaneous; success; translational approach; weight loss intervention; weight maintenance; young adult

DESCRIPTION (provided by applicant): Among the greatest public health concerns today is the rapid rise in obesity in the pediatric population, which now exceeds 18% in children (6-11 y) and 17% in adolescents (12-19 y), while obesity among young adults (20-39 y) approaches 30%. Though much has been learned regarding the regulation of body weight and the development of adiposity, the prevalence of obesity continues to rise, demonstrating that even today the factors that predict healthy weight maintenance remain poorly understood. In fact, the transition from overweight adolescent to obese adult is almost inevitable, with the probability of obesity in adulthood exceeding 50% among children >13 years of age whose BMI percentiles meet or exceed the 95th percentile for age and gender. But what if we could deter the expected transition from overweight adolescent to obese adult and intervene on a young person at a critical time when he/she is beginning to feel empowered by independence? This is the essence of the Training Interventions and Genetics of Exercise Response (TIGER) Study. The TIGER Study began in 2003 with the goal of identifying genetic factors that influence physiologic response to exercise training, while introducing sedentary college age individuals to regular exercise. Subjects in the TIGER Study currently underwent 30 weeks (2 semesters) of exercise training, 3 days per week for 40 minutes at 65-85% of age-predicted maximum heart rate. More than 80% of subjects lost weight or maintained their weight within 2 kg, and only 18% of subjects gained more than 2 kg. We have identified preliminary associations between gene variation and exercise dropout in the first phase of the study, and in phase 2 of the TIGER study, we will build on these observations. We will focus on three primary areas of investigation: 1) formal evaluation of the TIGER Study intervention protocol to achieve long-term change in the participants; 2) investigation of gene expression patterns in skeletal muscle and subcutaneous adipose tissue as a strategy for identifying genes related to exercise response; and 3) investigation of the association between genetic variation and exercise adherence. Subjects will undergo 35 weeks of exercise training based on the established TIGER protocol, and subjects will be re-contacted 6, 12, and 24 months following completion of the study protocol and questioned regarding current exercise habits and body weight. In addition, genetic analysis of candidate genes related to exercise behavior and neural signaling will be undertaken in order to identify genetic factors that may influence exercise adherence. Finally, patterns of gene expression in subcutaneous adipose, skeletal muscle, and peripheral leukocytes will be analyzed at baseline and following exercise training in order to identify factors that influence physiologic change consequent to exercise training. Results from this study are designed to enlighten our current understanding of how and why individuals respond and/or persist in exercise, with the ultimate goal of formulating better and more efficacious interventions for obesity. PUBLIC HEALTH RELEVANCE: Obesity established in adolescence strongly predicts obesity for the remainder of adult life, and the consequences are potentially devastating, characterized by a lifelong burden of co-morbid conditions and depression. This study will provide an exposure to physical activity that is designed to teach and empower sedentary college age individuals to become physically active by evaluating whether such exposure can result in lasting changes in exercise behavior and body composition. The study will also provide a better understanding of the genetic factors that influence persistence in an exercise program and that influence whole body response to exercise training.

描述（由申请人提供）：当今最大的公共卫生问题之一是小儿人群的肥胖症迅速增加，现在儿童（6-11 Y）和青少年（12-19岁）的肥胖症（6-11 Y）超过18％，而年轻人（20-39 Y）的肥胖症（20-39岁）的肥胖症30％。尽管关于体重的调节和肥胖的发展已经了解了很多，但肥胖的流行率仍在继续上升，这表明即使在今天，预测健康体重维持的因素仍然知之甚少。实际上，从超重青少年到肥胖成年人的过渡几乎是不可避免的，成年后肥胖的可能性超过50％的儿童> 13岁的BMI百分位数的年龄和性别的BMI百分位数超过了95％。但是，如果我们能够阻止从超重青少年到肥胖成年人的预期过渡，并在一个关键时刻开始对年轻人进行干预，当时他/她开始感到自己受到独立的能力，该怎么办？这是训练干预措施和运动反应遗传学（Tiger）研究的本质。老虎研究始于2003年，目的是确定影响对运动训练生理反应的遗传因素，同时引入久坐的大学时代的个人进行定期运动。老虎研究中的受试者目前接受了30周（2个学期）的运动训练，每周3天，持续40分钟，占年龄预测最大心率的65-85％。超过80％的受试者体重减轻或保持体重超过2公斤，只有18％的受试者获得了2公斤以上。我们已经确定了研究第一阶段的基因变异与运动辍学之间的初步关联，在Tiger研究的第二阶段，我们将基于这些观察结果。我们将重点关注调查的三个主要领域：1）对老虎研究干预方案的正式评估，以实现参与者的长期变化； 2）研究骨骼肌和皮下脂肪组织中基因表达模式，作为识别与运动反应有关的基因的策略； 3）研究遗传变异与遵守遗传变异之间的关联。受试者将根据已建立的老虎方案进行35周的运动训练，并且在完成研究方案后，受试者将重新接触6、12和24个月，并质疑当前的运动习惯和体重。此外，将进行与运动行为和神经信号相关的候选基因的遗传分析，以确定可能影响运动依从性的遗传因素。最后，将在基线和运动训练之后分析皮下脂肪，骨骼肌和周围白细胞中基因表达的模式，以确定影响运动训练带来的生理变化的因素。这项研究的结果旨在启发我们当前对个人如何以及为什么在运动中反应和/或持续存在的理解，其最终目标是为肥胖做出更好，更有效的干预措施。 公共卫生相关性：青春期建立的肥胖症在其余的成人生活中强烈预测肥胖症，而后果可能是毁灭性的，其特征是终生的合并症条件和抑郁症的负担。这项研究将提供对体育锻炼的接触，旨在通过评估这种暴露是否会导致运动行为和身体成分的持久变化，以教导和赋予久坐大学时代的个人能够变得身体活跃。该研究还将更好地了解影响运动计划中持久性的遗传因素，并影响整个身体对运动训练的反应。