Motion Compensated Brain PET Imaging for Neuroscience Research

用于神经科学研究的运动补偿脑 PET 成像

• 批准号: 9049061
• 负责人: David M Beylin
• 金额: $ 91.2万
• 依托单位: BRAIN BIO
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-15 至 2017-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9049061
• 关键词: Acceleration; Accounting; Adoption; Adverse effects; Agitation; Alcohol dependence; Algorithms; Alzheimer' s Disease; Biochemistry; Brain; Brain imaging; Calibration; Certification; Clinic; Clinical; Clinical Data; Clinical Research; Computer Vision Systems; Delirium; Devices; Disease; Distress; Drug Addiction; Drug abuse; Electromagnetics; Equipment; Etiology; Evaluable Disease; Face; Failure; Financial compensation; Freedom; Functional disorder; Funding; Glioblastoma; Guidelines; Head; Head Movements; Hospitals; Image; Imaging technology; Immune; Impaired cognition; Institutional Review Boards; Knowledge; Laboratory Research; Lighting; Magnetic Resonance Imaging; Malignant neoplasm of brain; Maryland; Mental disorders; Modeling; Morphologic artifacts; Motion; Motor Neuron Disease; Movement Disorders; Neurologic; Neurosciences Research; Parkinson Disease; Participant; Patients; Pharmaceutical Preparations; Phase; Physical Restraint; Positioning Attribute; Positron-Emission Tomography; Postoperative Period; Procedures; Qualifying; Quality Control; Radiology Specialty; Radiopharmaceuticals; Reader; Research; Resolution; Safety; Sales; Scanning; Schizophrenia; Sedation procedure; Small Business Innovation Research Grant; Software Design; Supervision; Syndrome; System; Testing; Universities; Vendor; base; brain metabolism; brain research; commercialization; cost; design; experience; improved; medical schools; nervous system disorder; novel; programs; prototype; public health relevance; reconstruction; restraint; sedative; uptake

 DESCRIPTION (provided by applicant): Advanced imaging technologies such as Positron Emission Tomography (PET) and Magnetic Resonance Imaging (MR) have led to remarkable improvement in our knowledge of brain metabolism, function, and biochemistry. And yet, our understanding of most neurological disorders is at best rudimentary. Etiology of such common diseases as drug and alcohol addiction, schizophrenia, Alzheimer's dementia and Parkinson's remains elusive. Malignant brain tumors such as glioblastoma continue being fatal. Changes happening in the brain in such common syndromes as hospital-acquired delirium, and post-operative cognitive decline, are not understood. Most studies involving advanced brain imaging remain small due to logistical challenges, cost constraints, and difficulty of scanning neurological patients in standard radiology equipment. Acceleration of brain research is required to elucidate the pathophysiology of neurological and psychiatric conditions. Brain Biosciences was established to make neurological imaging comfortable, inexpensive, and widely available both in the clinic and in the research laboratory. One of the common problems encountered in imaging research is unintentional patient motion. Head movement during Positron Emission Tomography (PET) degrades PET image quality, leads to image artifacts, and introduces quantitative errors. Motion is particularly common in confused patients with neurological diseases, drug addiction, and movement disorders. This problem becomes especially relevant as research involving lengthy dynamic scans, and high-resolution brain imaging becomes common. While sedation is often used to minimize the patient motion, sedative drugs change brain biochemistry, interfere with radiopharmaceutical uptake, and may cause side effects. Physical restraints are often distressing, and may increase patient agitation. In this direct Phase II SBIR proposal we seek to develop, clinically validate, and receive FDA clearance for FREEMotion(tm), a video-based head tracking system, enabling motion- compensated brain Positron Emission Tomography (PET) imaging of neurological patients without sedation or physical head restraint.

 描述（由适用提供）：高级成像技术，例如正电子发射断层扫描（PET）和磁共振成像（MR），导致我们对脑代谢，功能和生物化学的了解显着提高。但是，我们对大多数神经系统疾病的理解充其量是基本的。诸如药物和酒精成瘾，精神分裂症，阿尔茨海默氏症和帕金森氏症等常见疾病的病因仍然难以捉摸。恶性脑肿瘤（例如胶质母细胞瘤）继续致命。尚不清楚大脑中发生的大脑中发生的变化，例如医院获得的del妄和术后认知能力下降。由于后勤挑战，成本限制以及在标准放射学设备中扫描神经系统患者的难度，大多数涉及晚期大脑成像的研究仍然很小。需要大脑研究的加速来阐明神经系统和精神病的病理生理。建立了脑生物科学，以使神经系统成像在诊所和研究实验室中舒适，廉价且广泛使用。成像研究中遇到的常见问题之一是无意的患者运动。正电子发射断层扫描（PET）期间的头部运动降低了宠物图像质量，导致图像伪影并引入定量错误。运动在混乱患有神经系统疾病，药物成瘾和运动障碍的患者中尤为普遍。随着涉及冗长的动态扫描的研究，高分辨率的大脑成像变得普遍，此问题变得特别重要。虽然镇静通常用于最大程度地减少患者的运动，但镇静剂会改变脑生物化学，干扰放射性药物的摄取，并可能引起副作用。身体限制通常令人痛苦，可能会增加患者的躁动。在这个直接阶段 II SBIR提案我们寻求开发，临床验证和接收FDA清除freemotion（TM），这是一种基于视频的头部跟踪系统，可以在没有镇静剂或身体限制的情况下对神经系统患者进行运动补偿的脑正电子发射层析成像（PET）成像。