Developmental Research Program

发展研究计划

• 批准号: 8314129
• 负责人: Marc Ladanyi
• 金额: $ 4.42万
• 依托单位: SLOAN-KETTERING INST CAN RESEARCH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8314129
• 关键词: Address; Advisory Committees; Animals; Award; Basic Science; Biology; Budgets; Clinical; Clinical Investigator; Complement; Data; Development; Diagnosis; Disease; Eligibility Determination; Faculty; Funding; Future; Generations; Goals; Human; International; Intervention; Investigator-Initiated Research; Knowledge; Leadership; Measurement; Memorial Sloan-Kettering Cancer Center; Natural History; Newly Diagnosed; Pathogenesis; Patients; Pilot Projects; Process; Recruitment Activity; Research; Research Personnel; Research Project Grants; Scientific Evaluation; Seeds; Staging; Talents; Testing; Translational Research; base; career; improved; innovation; outcome forecast; preference; programs; sarcoma; soft tissue; success

Approximately 50% of patients with newly diagnosed sarcoma eventually die of disease. The purpose of the Developmental Research Program of the MSKCC SPORE in Soft Tissue Sarcoma is to support innovative translational research projects in sarcoma. The translational research projects in this program aim to use knowledge of animal and human sarcoma biology to develop and test interventions related to improving diagnosis, prognosis, and treatment of pafients with soft fissue sarcoma. This program will allow us to respond quickly to new opportunifies in translational research and will help us recruit new scientific talent into our SPORE and, more broadly, into sarcomarelevant research. The specific aims of the Developmental Research Program are: 1) to provide seed funding for innovative, investigator-initiated research in the biology, pathogenesis, progression, and natural history of sarcoma, 2) to fund research with exceptional potential to advance the translational research goals of the SPORE, and 3) to establish a mechanism for strategic interactions with other SPOREs and other major national and international research centers. We are budgeting $450,000 yeariy for this program including $50,000 from the SPORE award itself and $400,000 in MSKCC institutional funds. The priority for funding will be those inifiafives considered most creafive and of the highest scientific quality. Preference will be given to projects that complement the long-term research goals of the SPORE and advance our translational research objecfives. The executive committee can also solicit and fund experimental or clinical initiatives that address an urgent and specific need in the MSKCC SPORE in Soft Tissue Sarcoma program or a unique research opportunity. The internal scientific advisory committee, under the chairmanship of Murray F. Brennan, MD, will review applications to determine priorities for use of these funds and will annually select projects for one to two years of funding. The projects that appear most promising after two years of funding will be considered for incorporation into the SPORE as Research Projects, either in current or future funding cycles.

大约50％的新诊断为肉瘤的患者最终死于疾病。这 软组织肉瘤中MSKCC孢子的发展研究计划的目的是 支持肉瘤的创新转化研究项目。翻译研究项目 在该计划中，旨在利用动物和人类肉瘤生物学的知识来开发和测试 与柔软的裂隙的诊断，预后和治疗相关的干预措施 肉瘤。该计划将使我们能够快速回应转化研究的新机会 并将帮助我们将新的科学人才招募到孢子中，更广泛地招募到肉瘤 研究。发展研究计划的具体目的是：1）提供 用于创新，研究人员发起的创新研究，发病机理，进展， 和肉瘤的自然历史，2）资助具有极大潜力的研究 孢子的翻译研究目标，3）建立战略机制 与其他孢子以及其他主要国家和国际研究中心的互动。 我们将为该计划预算450,000年的$ 450,000年，包括孢子奖中的50,000美元 和40万美元的MSKCC机构资金。资金的优先事项将是那些无限股份 被认为是最刺耳的，具有最高的科学质量。优先偏爱项目 这补充了孢子的长期研究目标，并推动了我们的翻译 研究Objecfives。执行委员会还可以征求并资助实验或临床 解决软组织肉瘤中MSKCC孢子中紧急和特定需求的倡议 程序或独特的研究机会。内部科学咨询委员会， 马里兰州默里·布伦南（Murray F. Brennan）主席将审查申请，以确定使用的优先级 这些资金，每年将选择一到两年的资金项目。这些项目 两年后将考虑将其纳入其中，似乎是最有前途的 在当前或将来的资金周期中，孢子作为研究项目。