Novel Translational Approaches to BPH/LUTS

BPH/LUTS 的新颖转化方法

• 批准号: 8132352
• 负责人: WILLIAM B ISAACS
• 金额: $ 104.54万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2014-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8132352
• 关键词: Novel; Translational; Approaches; BPH; LUTS

Benign Prostatic Hyperplasia (BPH) or Lower Urinary Tract Symptoms (LUTS) represents one of the most common diseases occurring in aging men in the United States. These are complex diseases that require molecular classification and novel therapeutic approaches. To address these needs, we have prepared this application for a George M. O'Brien Urology Center which is focused on BPH/LUTS. The Center consists of four projects each of which is translational/clinical in nature. Project 1 is entitled, Intraprostatic Inflammation in the Etiology of Lower Urinary Tract Symptoms. Project 2 is on JM27 as a Potential Biomarker of Symptomatic BPH. Project 3 relates to Genetic Association Studies in BPH. These three projects are supported by an Administrative and a Bioresource Cores focused on biostatistics. The Administrative Core contains elements of the supporting structure for the Center along with the Pilot and Feasibility and Educational Enrichment Programs. This O'Brien Center should provide new insights and approaches to these common issues that effect almost all men as they age.

良性的前列腺增生（BPH）或较低的尿路症状（LUTS）代表了美国衰老男性中最常见的疾病之一。这些是需要分子分类和新型治疗方法的复杂疾病。为了满足这些需求，我们为乔治·M·奥布莱恩泌尿外科中心（George M. O'Brien）泌尿外科中心（George M.该中心由四个项目组成，每个项目本质上都是翻译/临床的。项目1的标题为较低尿路症状的病因中肉体内炎症。项目2在JM27上是潜在的生物标志物 有症状的BPH。项目3涉及BPH中的遗传关联研究。这三个项目得到了专注于生物统计学的行政和生物库的支持。行政核心包含该中心支持结构的要素以及飞行员以及可行性和教育丰富计划。这个奥布莱恩中心应为这些常见问题提供新的见解和方法，这些问题几乎随着年龄的增长而影响。