Research Network on Animal Models to Understand Social Dimensions of Aging

了解衰老社会维度的动物模型研究网络

基本信息

批准号：
10116254
负责人：
Alessandro Bartolomucci
金额：
$ 33.23万
依托单位：
DUKE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-03-01 至 2025-02-28
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10116254
关键词：
Address Advanced Development Age Aging Alcoholism American Animal Experimentation Animal Model Animals Applications Grants Area Awareness Behavior Therapy Behavioral Biological Biological Assay Biological Markers Cardiovascular Diseases Catalysis Clinical Research Collaborations Collection Communities Complex Controlled Environment Data Data Set Dementia Dimensions Discipline Disease Educational workshop Environment Etiology Exhibits Fellowship Generations Goals Grant Health Human Interdisciplinary Communication Knowledge Leadership Link Longevity Malignant Neoplasms Mammals Marmota Mentors Mentorship Methodology Methods Modeling Monoclonal Antibody R24 Morbidity - disease rate Nature Obesity Outcome Measure Paper Pathway interactions Pattern Personal Satisfaction Physiological Pilot Projects Population Population Research Population Study Predisposition Protocols documentation Publications Research Research Design Research Personnel Rodent Scientist Silk Social Behavior Social Environment Social Impacts Social Interaction Social isolation Social support Socioeconomic Status Standardization Stress Technology Testing Therapeutic Intervention Time Training Training Support Translations Travel United States Work Yang aging population animal data animal model development behavioral study career comparative cost data sharing design experience experimental study flexibility genomic data human data human model human population study improved innovation interest low socioeconomic status meetings mortality nonhuman primate programs recruit sedentary social social determinants social factors social health determinants social relationships social stress symposium therapeutic evaluation tool working group

项目摘要

Project Summary As the population of the United States ages, the health burden imposed by diseases of aging is expected to increase concomitantly. Social factors, including low socioeconomic status, social isolation, and low social support, are among the best predictors of susceptibility to diseases of aging, as well as lifespan itself. Nevertheless, key questions about the causal relationship and the biological mechanisms that link social experiences to health and aging remain unanswered. Animal models are a powerful tool to address these questions. Like humans, other social mammals exhibit strong associations between social adversity, health, and mortality. Unlike humans, though, they experience less complex environments, have shorter generation times, and can be subjected to experimental manipulation in controlled environments. The goal of this proposal is to build a Research Network on Animal Models to Understand Social Dimensions of Aging. By supporting interdisciplinary communication and pilot research from both human and nonhuman animal researchers, we aim to maximize the impact of animal model research on understanding the social determinants of health and aging. A Research Network is essential because current research in this area is distributed across many different disciplines, there is no standard set of conferences or publication venues where researchers with related interests overlap, and there are high barriers to entry for animal model work. The proposed network will overcome these challenges by supporting scientific meetings and workshops that build contacts across disciplines and among researchers at all career levels. It will also recruit new, diverse investigators into the field by providing opportunities for pilot project support, travel fellowships, and mentorship by experienced senior investigators. As part of these activities, the network will provide hands-on training for animal model research in rodents and nonhuman primates and for comparative research that leverages human and animal data sets. To build visibility, it will support targeted symposia at meetings where animal model work on the social dimensions of aging has not traditionally been represented. Finally, it will identify priority areas for animal model research and promote data and protocol dissemination. These activities will help set a research agenda that extends beyond the network’s immediate activities. Thus, the proposed network will transform a weakly connected community into a self-sustaining field of researchers equipped to conduct impactful research on the social dimensions of aging. Areas of particular interest include models to test the causal effects of social interactions on health; methods that can be flexibly deployed in both nonhuman animals and human populations; and research that investigates the benefits of behavioral interventions for alleviating the costs of social adversity. Advances in these areas will have direct translational application to human health and well-being during aging.

项目概要随着美国人口老龄化，预计老龄化疾病将带来健康负担社会因素也随之增加，包括低社会经济地位、社会孤立和低社会地位。支持，是对衰老疾病以及寿命本身的易感性的最佳预测因素之一。然而，关于因果关系和将社会联系起来的生物机制的关键问题动物模型是解决这些问题的有力工具。与人类一样，其他社会哺乳动物也表现出社会逆境、健康、然而，与人类不同的是，它们经历的环境不那么复杂，世代也更短。次，并且可以在受控环境中进行实验操作。该提案的目标是建立一个动物模型研究网络以了解社会老龄化的维度通过支持人类和人类的跨学科交流和试点研究。非人类动物研究人员，我们的目标是最大限度地发挥动物模型研究对理解健康和老龄化的社会决定因素至关重要，因为目前这方面的研究。领域分布在许多不同的学科，没有标准的会议或出版物集相关研究人员兴趣重叠、动物模型进入门槛较高的场所拟议的网络将通过支持科学会议和研讨会来克服这些挑战。它还将招募新的、跨学科的和各个职业级别的研究人员之间的联系。通过提供试点项目支持、旅行奖学金和作为这些活动的一部分，该网络将提供实践经验。啮齿动物和非人类灵长类动物模型研究以及比较研究的培训利用人类和动物数据集来建立可见性，它将支持在会议上举行有针对性的研讨会。传统上，关于老龄化社会维度的动物模型工作并未得到体现。确定动物模型研究的优先领域并促进数据和方案传播。将有助于制定超出网络直接活动范围的研究议程。因此，所提出的网络将把一个弱连接的社区转变为一个自我维持的领域研究人员有能力对特定领域的老龄化社会影响进行有影响力的研究。兴趣包括测试社交互动对健康的因果影响的模型，方法可以灵活运用；应用于非人类动物和人类；以及调查其益处的研究；减轻社会逆境成本的行为干预措施将产生直接影响。衰老过程中对人类健康和福祉的转化应用。