Cohort Registry of Type 1 Diabetes

1 型糖尿病队列登记

• 批准号: 8034973
• 负责人: Mari Palta
• 金额: $ 14.85万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-03-23 至 2011-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8034973
• 关键词: Address; Adolescence; Adolescent; Affect; Age; Albumins; Biological Assay; Body Composition; Cardiovascular Physiology; Caring; Clinical; Cohort Studies; Collaborations; Complications of Diabetes Mellitus; Cystatins; Data; Data Collection; Development; Diabetes Mellitus; Diabetic Angiopathies; Diabetic Retinopathy; Diagnosis; Dose; Epidemiologic Studies; Excretory function; Functional disorder; Fundus; Geographic Locations; Goals; Hypertension; Incidence; Individual; Insulin; Insulin Resistance; Insulin-Dependent Diabetes Mellitus; Insulin-Like Growth Factor I; Interview; Kidney; Lipids; Lipoproteins; Measures; Outcome; Pattern; Pharmaceutical Preparations; Plasma; Population; Predictive Value; Prevalence; Prevention; Protocols documentation; Registries; Renal function; Retinal Diseases; Role; Sampling; Thick; Time; United States; Wisconsin; adiponectin; cardiovascular risk factor; cohort; diabetes control; diabetes management; follow-up; glycemic control; illness length; insulin sensitivity; population based; post gamma-globulins; prognostic; urinary; waist circumference

DESCRIPTION (provided by applicant): The Wisconsin Diabetes Registry Study (WDRS) is following one of very few population-based cohorts with type 1 diabetes in the United States. The cohort is unique in being comprehensively described from the time of diagnosis during 1987-1992 until now, with respect to glycemic control, diabetes care and complications. Hence, the WDRS is well situated to: (1) Determine how population wide changes toward more intensive insulin therapy and diabetes management have affected microvascular outcomes. (2) Investigate how glycemic control, diabetes care, insulin resistance and other factors across adolescence develop and affect later outcomes. These goals will be achieved by extending the observations through the twentieth year of type 1 diabetes, a duration over which an increase in microvascular complications is expected to occur Collaboration with the Wisconsin Epidemiologic Study of Diabetic Retinopathy (WESDR), makes it possible to directly examine the potential decline in complications in the context of suspected improvements in diabetes care in the same geographic region overtime in individuals diagnosed 7-10 years apart. Participation in the WSDR cohort is excellent. Standardized protocols for examinations, including fundus photographs and interviews, have been implemented throughout follow-up and will be used during this additional period of data collection. Clinical examinations will establish accurate prognostic information for the incidence, prevalence, and progression of retinopathy, kidney dysfunction and hypertension at 18-20 years duration of type 1 diabetes. Extensive longitudinal data and an existing plasma bank will be used to examine the effects of diabetes management, insulin resistance, body composition, markers of cardiovascular risk and indicators of kidney damage across and past the critical adolescent years. Patterns in these indicators will be investigated as predictors of outcomes. Specifically, cystatin C will be used as a longitudinal measure of kidney function and cardiovascular risk, and IGF-1 and adiponectin will be used to examine the development and role of insulin sensitivity across adolescence. The importance of insulin sensitivity in type 1 diabetes has recently been realized, but its development has not been comprehensively studied. Findings on the predictive role of plasma lipids, body composition, insulin therapy and insulin resistance during adolescence could have important implications for prevention of diabetes complications.

描述（由申请人提供）：威斯康星州糖尿病注册表研究（WDRS）遵循美国与1型糖尿病的极少数基于人群的同类之一。从1987 - 1992年期间的诊断时间到现在，就血糖控制，糖尿病护理和并发症而言，该队列的全面描述是独一无二的。因此，WDR的位置很好：（1）确定种群在更密集的胰岛素治疗和糖尿病管理方面如何变化影响了微血管结局。 （2）研究血糖控制，糖尿病护理，胰岛素抵抗和其他青春期如何发展和影响以后的结果。这些目标将通过将观察结果扩展到第1型糖尿病的二十岁一年来实现，预计将与威斯康星州流行病学研究的持续时间增加微血管并发症的增加，这使糖尿病性视网膜病变（WESDR）（WESDR）的持续时间降低了，从而可以直接检查疾病的潜在疾病，从而直接研究疾病的潜在疾病的潜在疾病，从而在疾病中诊断了7个以上疾病的疾病，而疾病的可能性降低了。除外。参与WSDR队列非常好。在整个后续过程中都实施了用于考试的标准化协议，包括底眼镜照片和访谈，将在此额外的数据收集期间使用。临床检查将在1型糖尿病的18 - 20年持续时间（18 - 20年的持续时间持续时间）为视网膜病变，肾功能障碍和高血压的发病率和进展而建立准确的预后信息。广泛的纵向数据和现有的等离子库将用于检查糖尿病管理，胰岛素抵抗，身体成分，心血管风险的标志以及在关键青少年时期和过去和过去的肾脏损害指标。这些指标中的模式将作为结果的预测指标。具体而言，胱抑素C将用作肾功能和心血管风险的纵向测量，而IGF-1和脂联素将用于检查整个青春期胰岛素敏感性的发育和作用。最近已经实现了胰岛素敏感性在1型糖尿病中的重要性，但尚未对其发育进行全面研究。关于血浆脂质，身体组成，胰岛素治疗和青春期胰岛素抵抗的预测作用的发现可能对预防糖尿病并发症具有重要意义。

项目成果

Insulin-like growth factor-I is related to glycemic control in children and adolescents with newly diagnosed insulin-dependent diabetes.

胰岛素样生长因子-I 与新诊断的胰岛素依赖型糖尿病儿童和青少年的血糖控制有关。

• DOI: 10.1210/jcem.80.7.7608267
• 发表时间: 1995
• 期刊: The Journal of clinical endocrinology and metabolism
• 作者: Dills,DG;Allen,C;Palta,M;Zaccaro,DJ;Klein,R;D'Alessio,D
• 通讯作者: D'Alessio,D

Longitudinal Analysis of Adiponectin through 20-Year Type 1 Diabetes Duration.

• DOI: 10.1155/2015/730407
• 发表时间: 2015
• 期刊: Journal of diabetes research
• 影响因子: 4.3
• 作者: LeCaire TJ;Palta M
• 通讯作者: Palta M

Risk factors for hospitalization in a cohort with type 1 diabetes. Wisconsin Diabetes Registry.

1 型糖尿病队列中住院的危险因素。

• DOI: 10.1093/oxfordjournals.aje.a009328
• 发表时间: 1997
• 期刊: American journal of epidemiology
• 影响因子: 5
• 作者: Palta,M;LeCaire,T;Daniels,K;Shen,G;Allen,C;D'Alessio,D
• 通讯作者: D'Alessio,D

The trajectory of IGF-1 across age and duration of type 1 diabetes.

IGF-1 随年龄和 1 型糖尿病病程的变化轨迹。

• DOI: 10.1002/dmrr.2554
• 发表时间: 2014
• 期刊: Diabetes/metabolism research and reviews
• 作者: Palta,Mari;LeCaire,TamaraJ;Sadek-Badawi,Mona;Herrera,VictorM;Danielson,KirstieK
• 通讯作者: Danielson,KirstieK

Poor glycemic control is associated with low BMD detected in premenopausal women with type 1 diabetes.

• DOI: 10.1007/s00198-008-0763-3
• 发表时间: 2009-06
• 期刊: OSTEOPOROSIS INTERNATIONAL
• 影响因子: 4
• 作者: Danielson, K. K.;Elliott, M. E.;LeCaire, T.;Binkley, N.;Palta, M.
• 通讯作者: Palta, M.