Hot Flash Research Tool for Broad Population Research Studies

用于广泛人群研究的热潮研究工具

基本信息

批准号：
8129521
负责人：
GARY D HAVEY
金额：
$ 43.14万
依托单位：
ADVANCED MEDICAL ELECTRONICS CORPORATION
依托单位国家：
美国
项目类别：
财政年份：
2005
资助国家：
美国
起止时间：
2005-08-01 至 2013-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8129521
关键词：
Adhesives Affect Age Agonist American Androgens Area Back Cancer Survivor Chills Clinic Clinical Companions Computer software Data Development Devices Diagnostic Doctor of Medicine Doctor of Philosophy Documentation Education Electrocardiogram Electrodes Electroencephalography Electronics Elements Enantone Engineering Ensure Evaluation Event FDA approved Failure Flushing Frequencies Funding Future Galvanic Skin Response Gold Gonadotropin Hormone Releasing Hormone Health Heat Waves Heating Hot flushes Hour Human Infertility Laboratories Lead Life Longitudinal Studies Malignant neoplasm of prostate Market Research Marketing Measurement Measures Medical Medical Device Medical Device Safety Medical Electronics Menopausal Symptom Menopause Modeling Modification Monitor Night Sweating Ovarian Palpitations Patient Self-Report Performance Phase Physiological Physiological Processes Population Population Research Postmenopause Principal Investigator Process Production Protocols documentation Quality of life Regulatory Affairs Reporting Research Research Personnel Sales Scientist Severities Signal Transduction Skin Sleep Social Responsibility Sweat Sweating Symptoms System Technology Testing Therapeutic Studies Time United States National Institutes of Health Vasomotor Wireless Technology Woman Work base chemotherapy child bearing cost deprivation design diaries electric impedance endometriosis experience human study innovation instrumentation light weight malignant breast neoplasm medical schools men monitoring device oncology operation professor programs prototype public health relevance research study tool

项目摘要

DESCRIPTION (provided by applicant): This work is focused on exploring the physiological processes and therapies associated with hot flashes. The project proposes to develop a tool for use by researchers studying hot flashes in broad population research studies. Hot flashes are experienced by approximately 80 percent of American women between the ages of 45 and 54 and are a significant concern during menopause. Typically expressed as a period of intense heat with sweating, flushing and rapid heartbeat, episodes usually last from five to ten minutes, but have been reported to last as long as an hour. These events frequently occur at night, and may be repeated anywhere from a few times per week to dozens of times per day. No longer relegated simply to women reaching the end of their child bearing years, hot flashes now affect breast cancer survivors, women with chemotherapy-induced ovarian failure, oopherectomized women, women being treated for endometriosis or infertility with gonadotropin- releasing hormone (GnRH) agonists such as Lupron, and men with prostate cancer undergoing androgen deprivation therapy (ADT). Hot flashes are often disruptive and unpleasant, with broad overall health consequences affecting work responsibilities, social activities, sleep, etc. The fundamental physiological triggering mechanisms of hot flashes are not well understood although hot flash therapies are an area of active research often including large therapy trials in broad populations. These studies require an objective measure of the hot flash phenomenon that optimally correlates with self-reported diary data, is specific to hot flashes, and is accurate under ambulatory conditions. PUBLIC HEALTH RELEVANCE: The proposed project develops technology for researchers studying hot flashes in men and women.

描述（由申请人提供）：这项工作的重点是探索与潮热相关的生理过程和疗法。该项目提议开发一种工具，供研究人员在广泛的人群研究中研究潮热时使用。大约 80% 45 岁至 54 岁之间的美国女性都经历过潮热，这是更年期期间的一个重要问题。通常表现为一段酷热、出汗、潮红和心跳加快的时期，发作通常持续五到十分钟，但据报道可持续长达一个小时。这些事件经常发生在夜间，并且可能在任何地方重复，从每周几次到每天数十次。潮热不再仅仅局限于生育年龄结束的女性，现在还影响乳腺癌幸存者、化疗引起的卵巢功能衰竭的女性、卵巢切除的女性、接受促性腺激素释放激素 (GnRH) 激动剂治疗子宫内膜异位症或不孕症的女性例如 Lupron，以及接受雄激素剥夺疗法 (ADT) 的前列腺癌男性。潮热通常具有破坏性且令人不愉快，会产生广泛的整体健康后果，影响工作责任、社交活动、睡眠等。潮热的基本生理触发机制尚不清楚，尽管潮热治疗是一个活跃的研究领域，通常包括大型治疗在广泛人群中进行试验。这些研究需要对潮热现象进行客观测量，该测量与自我报告的日记数据最佳相关，针对潮热，并且在动态条件下准确。公共健康相关性：拟议项目为研究男性和女性潮热的研究人员开发技术。