Ultrasound Ablation on Bone Cancer Under CT Fluoroscopy
CT透视下骨癌超声消融
基本信息
- 批准号:8082600
- 负责人:
- 金额:$ 109.64万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2005
- 资助国家:美国
- 起止时间:2005-09-21 至 2013-05-31
- 项目状态:已结题
- 来源:
- 关键词:AblationAcousticsAdultAffectAftercareAlgorithmsAnatomyAnesthesia proceduresAnimal ModelAnimalsAnti-Inflammatory AgentsAnti-inflammatoryAreaAtelectasisBack PainBed restBiomedical ResearchBone DiseasesBone neoplasmsBraces-Orthopedic appliancesCaliberCaliforniaCancer ModelCancer PatientCannulasCardiopulmonaryCervicalClinicalClinical ResearchCollaborationsCommon NeoplasmCompression FractureComputer softwareComputersConduction AnesthesiaDataDeep Vein ThrombosisDepositionDevelopmentDevicesDiagnosisDiagnosticDiseaseDoseElectronicsElementsEquipmentEvaluationFamilyFamily suidaeFeedbackFinancial compensationFluoroscopyFractureFundingGeneral AnesthesiaGrantHealthHematologic NeoplasmsHospitalsHumanImageInterventionJointsLearningLengthLesionLife ExpectancyLocal TherapyLocationLymphomaLytic Metastatic LesionMagnetic Resonance ImagingMalignant - descriptorMalignant Bone NeoplasmMalignant NeoplasmsMalignant neoplasm of prostateMarketingMechanicsMedical TechnologyMetastatic LesionMetastatic Neoplasm to the BoneMethodologyMethodsModelingMonitorMorbidity - disease rateMultiple MyelomaNarcotic AnalgesicsNeedlesNeoplasm MetastasisNerve Root CompressionsNeurologic DysfunctionsOperative Surgical ProceduresOsteolysisOutcomeOutpatientsOutputPainPalliative CareParaparesisParaplegiaPathological fracturePatientsPatternPenetrationPerformancePharmaceutical PreparationsPhasePhysiciansPilot ProjectsPneumoniaPositioning AttributePreparationPreventiveProceduresPulmonary EmbolismQuadriparesesQuadriplegiaRadialRadiation therapyRadiofrequency Interstitial AblationRadiology SpecialtyRadiopharmaceuticalsRecoveryResearchResearch SubjectsSan FranciscoSchemeSecondary toShapesSkeletal systemSmall Business Innovation Research GrantSmall Business Technology Transfer ResearchSpecific qualifier valueSpinalSpinal CordSpinal NeoplasmsStructureSurfaceSymptomsSystemSystems IntegrationTechniquesTechnologyTemperatureTestingTherapeuticTherapeutic InterventionThermal Ablation TherapyTimeTissuesToxic effectTransducersUltrasonographyUnited StatesUniversitiesVariantVertebral columnWalkingWorkbasebisphosphonatebody systembonecancer therapychemotherapyclinical applicationclinical practicecomputerized data processingconventional therapycostdesigndosimetryflexibilityhigh riskhormone therapyimprovedin vivoinstrumentationinterstitialintraoperative imagingkillingsminimally invasivemortalityneoplasticneurosurgerypre-clinicalpreventprogramsprototyperesearch studysensorskillsspinal cord compressionspine bone structurestandard caresuccesstechnology developmenttomographytreatment planningtumorvalidation studiesvertebra body
项目摘要
DESCRIPTION (provided by applicant): Metastatic bone cancer and multiple myeloma affects over 600,000 people every year in the United States and cause progressive bone destruction that results in severe pain, fractures, and the inability to walk. Patients usually present with incapacitating pain secondary to osseous involvement, with or without vertebral collapse, and to spinal cord and/or nerve roots compression, commonly leading to paraplegia and quadriplegia. Conventional therapy consists of bed rest, bracing, anti-inflammatory, or narcotic analgesic medications, and radiation therapy. These conservative options (except radiation therapy) are not dissimilar from the management of osteoporotic compression fractures and are associated with the same type of complications, i.e., atelectasis and pneumonia, deep venous thrombosis and pulmonary embolism. Surgical options are not possible for all patients, but when indicated, they consist of heavy interventions such as corpectomy or cage placement, with significant postprocedural recovery periods and high morbidity and mortality rates in patients who often have limited life expectancies. In addition, multifocal vertebral lesions are common and may contraindicate surgery. Vertebroplasty affects the pain symptom and was not designed to treat cancer. Current options for local treatment of metastatic spine cancer are insufficient. The hypothesis is that thermal ablation with high intensity interstitial ultrasound (HIIU) specifically matched to the tumor size and shape can be safe and efficacious in the management of metastatic spine cancer. We propose to develop a mechanism to perform minimally invasive conformal ultrasound ablation under combined computer tomography (CT) and CT fluoroscopy (CTF) guidance. Our work indicates that this method may provide a consistent, reliable, and safe treatment option in a simple and cost-efficient manner. The unique aspect of our approach is the ability to destruct an asymmetric target volume with a single needle that does not need to be placed in the center of the lesion. Under CT/CTF image guidance, we insert the ablator, localize the ablator with respect to the target zone, and then electronically shape the energy output to conform the target. Thus moderate placement errors can be simply corrected electronically. We also can ablate difficult shapes located nearby sensitive structures. There is a strong clinical need to deliver a means to kill the tumor in a focused and safe way in this sensitive area, protecting the spinal cord, around which the tumor is likely to have caused significant bone destruction already. The ability to conform the energy to the shape of the tumor with a sharply defined fringe field is critical and would add very significant clinical value. This program will develop an integrated instrumentation - ablative treatment delivery system, establish safe and accurate percutaneous HIIU needle placement and tumor ablation under real-time quantitative CT/CTF guidance, develop appropriate clinical workflow, and demonstrate use in clinical application.
描述(由申请人提供):在美国,转移性骨癌和多发性骨髓瘤每年影响超过60万人,并造成渐进的骨骼破坏,导致严重的疼痛,骨折和无法行走。患者通常出现骨间参与,有或没有椎骨塌陷的丧失能力的疼痛,以及脊髓和/或神经根部压缩,通常导致瘫痪和四肢瘫痪。常规治疗包括床休息,支撑,抗炎或麻醉镇痛药和放射治疗。这些保守的选择(放射疗法除外)与骨质疏松压缩裂缝的治疗并不相同,并且与相同类型的并发症,即肺炎症和肺炎,深静脉血栓形成和肺栓塞有关。所有患者都无法进行手术选择,但是当指示时,它们包括诸如切割或笼子置换的大干预措施,术后恢复期明显,并且在预期寿命有限的患者中的发病率和高发病率和死亡率很高。此外,多灶性椎体病变很常见,可能会进行禁忌手术。椎体成形术会影响疼痛症状,并非旨在治疗癌症。当前局部治疗转移性脊柱癌的选择不足。假设是,与肿瘤大小和形状相匹配的高强度间隙超声(HIIU)的热消融在转移性脊柱癌的管理中可以安全有效。我们建议制定一种在组合计算机断层扫描(CT)和CT荧光镜检查(CTF)指导下进行微创保形超声消融的机制。我们的工作表明,此方法可以简单且具有成本效益的方式提供一致,可靠和安全的治疗选择。我们方法的独特方面是能够用单针破坏不对称的目标体积,而无需将其放置在病变的中心。在CT/CTF图像指导下,我们插入射击器,将射击器定位在目标区域,然后以电子方式塑造能量输出以构成目标。因此,可以简单地通过电子纠正中等位置误差。我们还可以消除附近敏感结构的困难形状。在该敏感区域中,以重点且安全的方式杀死肿瘤的方法有很大的临床需求,以保护脊髓,脊髓可能已经造成了巨大的骨骼破坏。将能量与肿瘤形状构成与明确定义的条纹场的能力至关重要,并且会增加非常重要的临床价值。该计划将开发综合仪器 - 消融治疗输送系统,在实时定量CT/CTF指导下建立安全,准确的经皮HIIU针头和肿瘤消融,开发适当的临床工作流程,并证明在临床应用中使用。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
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{{ truncateString('Everette C Burdette', 18)}}的其他基金
Image-guided ultrasound ablation for precision targeting of prostate cancer
图像引导超声消融精确靶向前列腺癌
- 批准号:
10449277 - 财政年份:2018
- 资助金额:
$ 109.64万 - 项目类别:
Image-guided ultrasound ablation for precision targeting of prostate cancer
图像引导超声消融精确靶向前列腺癌
- 批准号:
9757727 - 财政年份:2018
- 资助金额:
$ 109.64万 - 项目类别:
Image-guided ultrasound ablation for precision targeting of prostate cancer
图像引导超声消融精确靶向前列腺癌
- 批准号:
10255514 - 财政年份:2018
- 资助金额:
$ 109.64万 - 项目类别:
Image-guided ultrasound ablation for precision targeting of prostate cancer
图像引导超声消融精确靶向前列腺癌
- 批准号:
10004592 - 财政年份:2018
- 资助金额:
$ 109.64万 - 项目类别:
Image-Guided Transurethral HIFU for Genitourinary Therapy
图像引导经尿道 HIFU 泌尿生殖治疗
- 批准号:
9049577 - 财政年份:2015
- 资助金额:
$ 109.64万 - 项目类别:
Image-Guided Transurethral HIFU for Genitourinary Therapy
图像引导经尿道 HIFU 泌尿生殖治疗
- 批准号:
10259640 - 财政年份:2015
- 资助金额:
$ 109.64万 - 项目类别:
Image-Guided Transurethral HIFU for Genitourinary Therapy
图像引导经尿道 HIFU 泌尿生殖治疗
- 批准号:
10452639 - 财政年份:2015
- 资助金额:
$ 109.64万 - 项目类别:
Robotic System with Multiplexed DOF Control for Minimally Invasive Interventions
用于微创干预的具有多自由度控制的机器人系统
- 批准号:
8253123 - 财政年份:2012
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$ 109.64万 - 项目类别:
PET-determined prostate brachytherapy dosing using intraoperative image-guidance
使用术中图像引导 PET 确定前列腺近距离放射治疗剂量
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9382210 - 财政年份:2010
- 资助金额:
$ 109.64万 - 项目类别:
PET-determined prostate brachytherapy dosing using intraoperative image-guidance
使用术中图像引导 PET 确定前列腺近距离放射治疗剂量
- 批准号:
9505848 - 财政年份:2010
- 资助金额:
$ 109.64万 - 项目类别:
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