Modifying Young Adult Skin Cancer Risk and Protective Behaviors (UV4.me2):A Hybrid Type 2 Dissemination/Effectiveness Trial

改变年轻成人皮肤癌风险和保护行为 (UV4.me2)：2 型传播/有效性混合试验

• 批准号: 10050020
• 负责人: Carolyn Heckman
• 金额: $ 48.07万
• 依托单位: RBHS -CANCER INSTITUTE OF NEW JERSEY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-12-01 至 2023-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10050020
• 关键词: Address; Adolescent; Adoption; Adult; American Cancer Society; Assessment tool; Baseline Surveys; Behavior; Behavioral; Behavioral Model; Cancer Prevention Intervention; Communities; Cost Analysis; Data; Diagnosis; Dissemination and Implementation; Effectiveness; Effectiveness of Interventions; Enrollment; Epidemic; Ethnic Origin; Evidence based intervention; Feedback; Funding; General Population; Goals; Hybrids; Incentives; Incidence; Individual; Institution; Internet; Intervention; Literature; Maintenance; Malignant Neoplasms; Nature; Nonprofit Organizations; Online Systems; Organ; Outcome; Pamphlets; Participant; Patient Recruitments; Population; Process; Public Health; Questionnaires; Race; Randomized; Randomized Controlled Trials; Reach, Effectiveness, Adoption, Implementation, and Maintenance; Research; Research Personnel; Risk Assessment; Risk Behaviors; Risk Factors; Sampling; Self Administration; Skin; Skin Cancer; Source; Sunburn; Surgeon; Tissues; UV Radiation Exposure; Ultraviolet Rays; Update; Work; age group; aged; base; behavior prediction; behavioral outcome; cancer risk; cost; cost effectiveness; demographics; effectiveness trial; efficacy study; efficacy trial; follow-up; high risk; implementation intervention; implementation strategy; improved; interactive multimedia; intervention cost; intervention effect; melanoma; multidisciplinary; news; novel; novel strategies; online intervention; peer; programs; protective behavior; recruit; satisfaction; skin cancer prevention; social media; uptake; web-based intervention; young adult

Abstract Skin cancer is a growing epidemic, with almost five million US diagnoses annually, in contrast with most cancers, which are decreasing in incidence. Although largely preventable, skin cancers can be deadly, debilitating, damaging, and disfiguring. US adolescents have the lowest skin protection rates of all age groups and also engage in increased ultraviolet radiation (UV) exposure as they move into adulthood. Thus, young adults are in need of intervention to reduce their skin cancer risk. Prior interventions to increase skin protection and/or decrease UV exposure among young adults have been limited in their dissemination and longitudinal assessment, and no prior interventions targeted to this population have been internet-based besides our own. Our research team developed a web-based intervention that was found to significantly decrease UV exposure and increase skin protection behaviors among young adults in a randomized controlled trial (RCT) of nearly 1000 participants recruited from a consumer research panel. The intervention (UV4.me) is individually-tailored, interactive, and multimedia in nature, and based on the Integrative Model of Behavioral Prediction. Similar to other online trials, 73% of eligible individuals completed the baseline questionnaire, 70% who were randomized to the intervention accessed it, and 68% accessed it and completed at least one module. However, we have an opportunity to increase the engagement, implementation, and ultimately, the impact of UV4.me. We will do this by adding several key interactive features/strategies suggested by participants, our data, and supported by the literature (i.e., by creating a mobile version, adding incentives embedded in the intervention, a behavior tracking and feedback feature, peer interaction component, and ongoing news updates). This Hybrid Type 2 dissemination-effectiveness project's purpose is to implement the enhanced UV4.me2 with adults aged 18-25 years at moderate to high risk of developing skin cancer and evaluate the intervention's effectiveness in a sample recruited online through national dissemination to the general population. This project will use the RE-AIM framework to determine the reach, effectiveness, implementation, maintenance, and cost of UV4.me2. The team will recruit individuals from several general online sources (e.g., nonprofits, social media, commercial). Our team has already recruited three non-profit organizations to promote uptake of UV4.me2 and a commercial skincare company to offer incentives to encourage participation of young adults from across the US. In order to evaluate intervention effectiveness, young adults who enroll in the study will be randomized to either receive the enhanced UV4.me2, the original UV4.me, or a skin cancer e-pamphlet from the American Cancer Society. In summary, this project proposes a novel approach to address an issue of growing public health significance. The uniquely well-suited multidisciplinary and multi-institution research team is comprised of junior, mid-level, and senior investigators who have previously worked together successfully on skin cancer prevention interventions.

抽象的 皮肤癌是一种日益流行的疾病，与大多数癌症相比，美国每年诊断出近 500 万人， 其发病率正在下降。虽然皮肤癌在很大程度上是可以预防的，但它可能是致命的、使人衰弱的、 损坏、毁容。美国青少年的皮肤保护率是所有年龄段中最低的，而且 当他们进入成年期时，会增加接触紫外线 (UV) 的机会。因此，年轻人处于 需要干预来降低他们的皮肤癌风险。事先进行干预以增强皮肤保护和/或 年轻人中紫外线暴露的减少在其传播和纵向方面受到限制 评估，除了我们自己的干预措施之外，之前没有针对这一人群的干预措施是基于互联网的。 我们的研究团队开发了一种基于网络的干预措施，发现可以显着减少紫外线照射 在一项涉及近 1000 名受试者的随机对照试验 (RCT) 中，提高年轻人的皮肤保护行为 参与者是从消费者研究小组中招募的。干预措施 (UV4.me) 是单独定制的， 本质上是交互式的和多媒体的，并且基于行为预测的综合模型。类似于 其他在线试验中，73% 的合格个体完成了基线调查问卷，其中 70% 被随机分配 参与干预的人访问了它，68% 的人访问了它并完成了至少一个模块。然而，我们有一个 增加 UV4.me 的参与、实施并最终影响的机会。我们会这样做 通过添加参与者、我们的数据建议并得到 文献（即，通过创建移动版本、添加嵌入干预措施的激励措施、行为跟踪 和反馈功能、同伴互动组件和持续的新闻更新）。这种混合型 2 传播有效性项目的目的是针对 18-25 岁的成年人实施增强型 UV4.me2 患皮肤癌的中度至高度风险的年份，并评估样本中干预措施的有效性 通过在全国范围内向广大民众传播的方式在线招募。该项目将使用 RE-AIM 确定 UV4.me2 的范围、有效性、实施、维护和成本的框架。团队 将从几个一般在线来源（例如非营利组织、社交媒体、商业）招募个人。我们的团队 已经招募了三个非营利组织来促进 UV4.me2 和商业护肤品的使用 公司提供激励措施，鼓励美国各地的年轻人参与。为了评估 干预效果，参加该研究的年轻人将被随机分配接受增强干预 UV4.me2，原始 UV4.me，或来自美国癌症协会的皮肤癌电子小册子。总之， 该项目提出了一种新颖的方法来解决日益重要的公共卫生问题。独一无二的 由初、中、高级组成的多学科、多机构的优秀研究团队 此前曾在皮肤癌预防干预方面成功合作的研究人员。