A Wireless Small Animal Monitor

无线小动物监视器

• 批准号: 8073636
• 负责人: B EUGENE PARKER
• 金额: $ 30.92万
• 依托单位: BARRON ASSOCIATES, INC.
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2013-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8073636
• 关键词: Accreditation; Animal Experiments; Animal Housing; Animal Welfare; Animals; Anus; Archives; Area; Behavioral Sciences; Charge; Collaborations; Communication; Computer software; Computers; Conscious; Contractor; Custom; Data; Data Display; Development; Devices; Docking; Dorsal; Elderly; Electrocardiogram; Electronics; Engineering; Environmental Impact; Evaluation Methodology; Event; Faculty; Freedom; Gait; Goals; Graph; Heart Rate; Hour; Housing; Individual; Information Systems; Institutes; International; Internet; Investigation; Laboratories; Laboratory Animals; Life; Lithium; Marketing; Measures; Mechanics; Monitor; Motion; Mus; Operative Surgical Procedures; Phase; Physical activity; Physiologic Monitoring; Physiological; Polymers; Process; Protocols documentation; Rattus; Research; Research Design; Research Methodology; Resistance; Rodent; Running; Safety; Services; Skin Temperature; Small Business Innovation Research Grant; Solutions; Stream; Surface; System; Temperature; Testing; Time; United States National Institutes of Health; Universities; Vertebrates; Virginia; Visual; Wireless Technology; Work; animal care; base; checkup examination; cost; data exchange; design; falls; implantation; improved; innovation; instrument; instrumentation; monitoring device; programs; public health relevance; remote sensing; research and development; research study; respiratory; sensor; skills; software systems; success; usability; wireless fidelity

DESCRIPTION (provided by applicant): The proposed Phase II research program focuses on the development of a wireless Small Animal Physiological Monitor (SAM). The SAM system will provide the capability to monitor up to 16 laboratory animals (initially rats and mice) simultaneously, with continuous recording, synchronization, and display of physiological data, including heart rate, respiratory rate, motion activity, skin temperature, and ambient temperature. Data will be collected from each animal via a miniature, lightweight "backpack" that is worn on the dorsal surface of the animal, with sensors integrated into an appropriately-sized, chew-resistant design. Optional wireless cameras can be mounted in laboratories or animal housing areas and integrated into the SAM system for remote visual monitoring of animals in real time. SAM system data (both physiological and video data) will be uploaded wirelessly to a shared receiver unit that interfaces to a PC (which can be local or over the Internet). The PC will consolidate the incoming data stream(s), archive all data on a hard disk, and provide real-time data display, enabling remote, simultaneous monitoring of all instrumented animals. The proposed Phase II research follows a successful Phase I effort that demonstrated proof of concept and feasibility for the SAM system in both anesthetized (supine) and conscious (prone) rats and mice. The Phase II research will involve creation of a fully-functional, commercially-viable SAM system that will be evaluated in laboratory experiments conducted on a variety of rats and mice, including several animals simultaneously over a one-week period. The SAM system will significantly refine animal welfare for many research experiments by eliminating the need for surgical implantation of sensors and providing the capability for wireless monitoring of key physiological variables. PUBLIC HEALTH RELEVANCE: The SAM system will provide improved instrumentation that will facilitate biomedical and behavioral science investigations across essentially all NIH institutes, as rats and mice are the most commonly used vertebrates in research. Additionally, the SAM system will enable research in areas that are presently constrained by the absence of suitable monitoring devices. For example, many questions regarding housing and husbandry practices of rodents and the impact of environmental conditions and/or external events on these animals remain unanswered.

描述（由申请人提供）：拟议的II期研究计划着重于无线小动物生理监测仪（SAM）的开发。 SAM系统将提供能够同时监测多达16只实验动物（最初是大鼠和小鼠）的能力，并连续记录，同步和显示生理数据，包括心率，呼吸速度，运动活动，皮肤温度和环境温度。数据将通过在动物的背侧表面上的微型，轻巧的“背包”从每种动物中收集，并将传感器整合到适当尺寸的耐咀嚼设计中。可选的无线摄像机可以安装在实验室或动物外壳区域中，并集成到SAM系统中，以实时远程视觉监测动物。 SAM系统数据（生理数据和视频数据）将被无线上载至连接到PC的共享接收器单元（可以是本地或通过Internet）。 PC将巩固传入的数据流，存档硬盘上的所有数据，并提供实时数据显示，从而实现对所有仪器动物的遥控，同时监视。 提出的第二阶段研究遵循了一项成功的第一阶段努力，该研究证明了在麻醉（仰卧）和有意识（俯卧）大鼠和小鼠中的SAM系统的概念证明和可行性。第二阶段的研究将涉及创建一个功能齐全的，商业上可行的SAM系统，该系统将在一周内对各种大鼠和小鼠进行的实验室实验中进行评估，其中包括几只动物。 SAM系统将通过消除对传感器的手术植入的需求并提供无线监测关键生理变量的无线监测能力，从而为许多研究实验提供显着完善动物福利。 公共卫生相关性：SAM系统将提供改进的仪器，这将促进基本所有NIH研究所的生物医学和行为科学调查，因为大鼠和小鼠是研究中最常用的脊椎动物。此外，SAM系统将在目前缺乏合适的监视设备限制的领域进行研究。例如，有关啮齿动物的住房和饲养做法以及环境状况和/或外部事件对这些动物的影响的许多问题仍然没有得到解答。