ANIMAL CORE

动物核心

基本信息

批准号：
7690365
负责人：
ALAN W HELDMAN
金额：
$ 12.97万
依托单位：
CEDARS-SINAI MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/7690365
关键词：
Accreditation Acetates Adult Aliquot American Amoxicillin Anatomy Anesthesia procedures Angiography Animal Care and Use Committees Animal Experimentation Animal Experiments Animal Hospitals Animal Housing Animal Model Animals Anterior Anterior Descending Coronary Artery Antibiotic Prophylaxis Antibiotics Apical Applications Grants Area Arts Aspirin Balloon Occlusion Bandage Benzathine Penicillin Biochemical Biopsy Blood Blood flow Blood gas Bolus Infusion Bone Marrow Boston Buprenorphine Caliber Cardiac Cardiac Catheterization Procedures Cardiac Surgery procedures Cardiology Cardiopulmonary Bypass Cardioscopes Cardiovascular Diseases Cardiovascular Models Cardiovascular system Carotid Arteries Catheterization Catheters Cefazolin Cells Charge Chemistry Chest Chest Tubes Clinic Clinical Research Clinical Trials Clip Condition Congestive Heart Failure Coronary Coronary Vessels Coronary artery Coronary sinus structure Daily Data Defibrillators Development Devices Diagnostic Diltiazem Distal Ear Economic Inflation Electric Countershock Electrocardiogram Electrocoagulation Employee Strikes Endocardium Ensure Epicardium Equipment Family suidae Fentanyl Film Fluoroscopy Gene Delivery Gentamicins Heart Heparin Hospitals Hour Housing Human Image Indwelling Catheter Infarction Infection Inferior Inferior vena cava structure Infusion procedures Injection of therapeutic agent Institution Institutional Policy Intervention Intramuscular Intravenous Bolus Investigation Ireland Irrigation Ischemia Ketamine Laboratories Laboratory Animals Laboratory Research Left Left ventricular structure Letters Lidocaine Lighting Measurement Mechanical Ventilators Mechanical ventilation Mediastinal Mesenchymal Stem Cells Metric Modeling Molecular Monitor Muscle Cells Myocardial Myocardial Infarction Myocardial dysfunction Myocardial tissue Myocardium Neck Needles Operating Rooms Operative Surgical Procedures Oxygen Pain Pain management Participant Pentobarbital Sodium Percutaneous Transluminal Coronary Angioplasty Performance Pericardial body location Pharmaceutical Preparations Phosphate Buffer Physiological reperfusion Physiology Placement Plastics Postoperative Period Preparation Procedures Production Protocols documentation Ptosis Radiology Specialty Records Recovery Recovery Room Regulation Reperfusion Therapy Research Resources Resuscitation Right atrial structure Safety Saline Sampling San Francisco Secure Services Shapes Site Skin Solutions Stem cells Sterility Sterilization for infection control Sternotomy Sternum Surgical Clips Surgical sutures Sus scrofa System Techniques Technology Thoracic aorta Time Tissues Training Translational Research Translations Triton Ultrasonics Ultrasonography Universities Veins Venous Ventricular Ventricular septum Visual Work animal care animal resource aortic valve auricular appendage base chiron vaccine clinical application day digital experience hemodynamics human subject in vivo instrument instrumentation novel pericardial sac pressure programs research study size success tool xanthine oxidase inhibitor

项目摘要

The Animal Core will provide expertise in planning, performing, and interpreting experiments performed in large animal models of human cardiovascular disease. The resources of the Animal Core allow humane and efficient utilization of swine for survival surgery, catheterization procedures, and hemodynamic assessments. These resources have operated smoothly through a variety of other translational research programs including the development of cardiovascular devices and diagnostic tools; large animal experiments in our area have led in many cases directly to human clinical trials. For the projects in this proposal, preparation and instrumentation of swine to model ischemic myocardial dysfunction will be done by techniques established and operating in our group. Delivery of bone marrow derived mesenchymal stem cells and of cardiac stem cells to swine hearts in vivo will be done under conditions and using devices which mimic and parallel planned clinical studies. The director of the Animal Core is also a key participant in the clinical trials in Projects 1 and 3, and the use of newer cell delivery techniques in the swine model will benefit the safety of human subjects in the clinical studies, as the experience gained in the Animal Core transfers directly to the clinical studies.

动物核心将在人类心血管疾病大型动物模型中进行计划，执行和解释实验方面提供专业知识。动物核心的资源允许人道，有效利用猪生存手术，导管插入程序和血液动力学评估。这些资源通过其他各种翻译研究计划顺利运行，包括开发心血管设备和诊断工具。在许多情况下，我们地区的大型动物实验已导致人类临床试验。对于此提案中的项目，将通过在我们的小组中建立和运行的技术来完成猪的制备和仪器对脑部心肌功能障碍进行建模。骨髓衍生的间充质干细胞和心脏干细胞的递送在体内猪心脏的递送将在条件下以及使用模仿和平行计划的临床研究的设备进行。动物核心的主管也是项目1和3的临床试验的关键参与者，猪模型中使用较新的细胞输送技术将使人类受试者在临床研究中的安全有益，因为在动物核心转移中获得的经验直接转移到临床研究中。