Cell Migration Consortium

细胞迁移联盟

• 批准号: 7906696
• 负责人: ALAN F. Rick HORWITZ
• 金额: $ 669.14万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-15 至 2014-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7906696
• 关键词: Cell; Migration; Consortium

Migration is a pivotal process in many phenomena including embryonic development, cancer, inflammation, and wound repair. Understanding the mechanisms of cell migration present a formidable challenge, since it is comprised of several complex cellular processes coordinated in space and time. The Cell Migration Consortium is a highly interactive, multidisciplinary effort focused on bringing novel technical and intellectual solutions to the barriers to progress in migration research. It is organized into interdisciplinary Initiatives, virtual collaborative laboratories, focused on developing enabling technologies, reagents and models to address these barriers to progress. In the Consortium's next phase the emphasis will shift from technology development to its use in addressing major questions in the field. The Consortium goals are: to determine, identify, catalogue, and characterize the migration proteome, 2) formulate mathematical models to describe the steps in migration and integrate them into a comprehensive model of migration, 3) establish reagents and methods to measure, activate, and inactivate local signals that regulate migration, 4) determine the structures of the large multi-molecular machines that drive migration, and 5) promote migration research in the community and lower barriers for entry into the field. To achieve these goals enabling technologies developed by the individual Initiatives will be shared across the Consortium via inter-Initiative collaborations both inside and outside the migration community. The Consortium is organized into 7 Initiatives. Proteomics (mass spectrometry based analyses of phosphorylation and binding partners), Discovery (expression assays to identify migration molecules in several organisms), Transgenic and Knockout Mouse (production of conditional knockout and RNAi knockdown mice), Structure (determination of high resolution structures of migration complexes), Biosensors (development and application of new biosensors to measure spatial signaling), Imaging and Photomanipulation (development and application of photoactivation, photoinactivation, traction force assays, and correlation microscopy), Modeling (develop mathematical models of cell migration), and a Data Coordination and Dissemination Core (organize information for the Consortium and the community. The Consortium resources will be disseminated to the Community via the Cell Migration Gateway, a collaboration with the Nature Publishing Group.

迁移是许多现象中的关键过程，包括胚胎发育，癌症，炎症和伤口修复。理解细胞迁移的机制带来了巨大的挑战，因为它由时空协调的几个复杂的细胞过程组成。细胞迁移财团是一种高度互动的多学科努力，旨在将新颖的技术和智力解决方案带入移民研究进步的障碍。它被组织为跨学科计划，虚拟协作实验室，致力于开发启用技术，试剂和模型以解决这些进步障碍。在财团的下一阶段，重点将从技术开发转变为解决该领域主要问题的使用。 The Consortium goals are: to determine, identify, catalogue, and characterize the migration proteome, 2) formulate mathematical models to describe the steps in migration and integrate them into a comprehensive model of migration, 3) establish reagents and methods to measure, activate, and inactivate local signals that regulate migration, 4) determine the structures of the large multi-molecular machines that drive migration, and 5) promote migration research in the community and lower进入现场的障碍。为了实现这些目标，由个人倡议开发的技术将通过迁移社区内外的批判性合作在整个财团中共享。该财团分为7个倡议。 Proteomics (mass spectrometry based analyses of phosphorylation and binding partners), Discovery (expression assays to identify migration molecules in several organisms), Transgenic and Knockout Mouse (production of conditional knockout and RNAi knockdown mice), Structure (determination of high resolution structures of migration complexes), Biosensors (development and application of new biosensors to measure spatial signaling), Imaging and光感渗透（光活化，光激活，牵引力测定和相关显微镜的开发和应用），建模（发展细胞迁移的数学模型）以及数据协调和传播核心（为财团和社区组织信息。联盟和财团的信息。财团将通过细胞迁移与社区的迁移与社区的合作进行分配，并与性质的合作进行分配。